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The protein encoded by MST1 contains four kringle domains and a serine protease domain, similar to that found in hepatic growth factor. Zusätzlich bieten wir Ihnen MST1 Antikörper (101) und MST1 Kits (45) und viele weitere Produktgruppen zu diesem Protein an.
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Findings indicate that long-term exposure to IM results in dysregulation of stem cell renewal-regulatory Hippo (MST1/2)/YAP (zeige YAP1 Proteine) signaling, and that inhibition of miR (zeige MLXIP Proteine)-181a using a microRNA sponge inhibitor resulted in decreased transcription of SOX2 (zeige SOX2 Proteine) and SALL4 (zeige SALL4 Proteine).
These data suggest that MSP (zeige MSMB Proteine) is an effective inhibitor of inflammation and lipid accumulation in the stressed liver, thereby indicating that MSP (zeige MSMB Proteine) has a key regulatory role in non-alcoholic steatohepatitis.
Study found that MST1 is strongly activated in a diabetic beta cell and induces not only its death but also directly impairs insulin (zeige INS Proteine) secretion through promoting proteasomal degradation of key beta cell transcription factor, pancreatic and duodenal homeobox 1 (PDX1 (zeige PDX1 Proteine)), which is critical for insulin (zeige INS Proteine) production.
deacetylation of MST1 mediated by HBXIP-enhanced HDAC6 results in MST1 degradation in a chaperone-mediated autophagy (CMA) manner in promotion of breast cancer growth.
TNFAIP8 regulates Hippo (MST1/2) signaling through its interaction with LATS1.
Data suggest that Hippo (MST1/2 protein kinases) - Yes associated protein 1 (YAP (zeige YAP1 Proteine)) pathway involved in carcinogenesis of pancreatic cancer and in the inhibition effect of stiehopus japonieus acidic mucopolysaccharide (SJAMP) to the proliferation of pancreatic cancer cell.
our results identified that mammalian sterile 20-like kinase 1 (zeige STK4 Proteine) is a novel downstream target of pyruvate kinase M2, and knockdown of pyruvate kinase M2 contributes apoptosis via promoting nuclear translocation of mammalian sterile 20-like kinase 1 (zeige STK4 Proteine) by enhancing Caspase-3 (zeige CASP3 Proteine)-dependent cleavage.
H-ras (zeige HRAS Proteine), via an Erk (zeige EPHB2 Proteine)-dependent mechanism, downregulates Mst1/Mst2 (zeige STK3 Proteine) activity by inducing the formation of inactive Mst1/Mst2 (zeige STK3 Proteine) heterodimers.
Mst1 as a novel physiological negative regulator of IRF3 (zeige IRF3 Proteine) activation provides mechanistic insights into innate antiviral defense and potential antiviral prevention strategies.
Mst1 increases the (zeige FOXP3 Proteine)acetylation of Foxp3 by inhibiting Sirt1 activity, which requires the Mst1 kinase activity.
These data suggest that MSP is an effective inhibitor of inflammation and lipid accumulation in the stressed liver, thereby indicating that MSP has a key regulatory role in non-alcoholic steatohepatitis.
kinases, including Slk (zeige SLK Proteine), Lok (zeige STK10 Proteine) and Mst1, are inhibited by BI-D1870 but to a much lesser extent by BIX 02565 and that phosphorylation of some of their substrates is blocked by BI-D1870 in living cells.
Nicorandil alleviates post-MI cardiac dysfunction and remodeling. The mechanisms were associated with enhancing autophagy and inhibiting apoptosis through Mst1 inhibition.
Using a standard two-thirds partial hepatectomy (PH) model in young and aged mice, the activity of the core kinases MST1 and LATS1 increased during the early hypertrophic phase and returned to steady state levels in the proliferative phase, coinciding with activation of YAP1 (zeige YAP1 Proteine) target genes and hepatocyte proliferation.
The MST1 acts as a molecular brake to maintain immune tolerance by regulating T cell-mediated B cell activation (zeige BLNK Proteine).
Mst1 knockout alleviated while Mst1 overexpression aggravated cardiac dysfunction in diabetes.
these findings highlight a role for MST1 in vesicle trafficking and extravasation in neutrophils, providing an additional mechanistic explanation for the severe immune defect
Results identify L-plastin (zeige LCP1 Proteine) as a key effector of Mst1 and establish a novel mechanism linking a signaling intermediate to an actin-binding protein (zeige PFN1 Proteine) critical to T cell migration.
MIST1 is a scaling factor necessary and sufficient by itself to induce and maintain secretory cell architecture
Mst1 deficiency diminishes atherosclerosis and stabilizes atherosclerotic plaques in ApoE (zeige APOE Proteine)(-/-) mice. Mst1 may participate in atherosclerosis progression through inhibition of macrophage autophagy and promotion of macrophage apoptosis.
The protein encoded by this gene contains four kringle domains and a serine protease domain, similar to that found in hepatic growth factor. Despite the presence of the serine protease domain, the encoded protein may not have any proteolytic activity. The receptor for this protein is RON tyrosine kinase, which upon activation stimulates ciliary motility of ciliated epithelial lung cells. This protein is secreted and cleaved to form an alpha chain and a beta chain bridged by disulfide bonds.
, STE20-like kinase MST1
, dJ211D12.2 (serine/threonine kinase 4 (MST1, KRS2))
, kinase responsive to stress 2
, mammalian STE20-like protein kinase 1
, mammalian sterile 20-like 1
, serine/threonine-protein kinase 4
, serine/threonine-protein kinase Krs-2
, hepatocyte growth factor-like protein
, hepatocyte growth factor-like protein homolog
, macrophage-stimulating protein
, E2F transcription factor 2
, macrophage stimulatory protein
, hepatocyte growth factor-like/macrophage stimulating protein
, macrophage stimulating 1 (hepatocyte growth factor-like)
, 12S E1A
, macrophage stimulating 1 L homeolog