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The protein encoded by MST1 contains four kringle domains and a serine protease domain, similar to that found in hepatic growth factor. Zusätzlich bieten wir Ihnen MST1 Antikörper (102) und MST1 Proteine (15) und viele weitere Produktgruppen zu diesem Protein an.
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In the present study, we investigated the expression of activated core Hippo pathway kinases (pMST1/2 and pLATS1/2) in a series of 57 HER2 (zeige ERBB2 ELISA Kits)-positve and triple-negative breast cancer patients who received neoadjuvant therapy .
Through a comprehensive set of biochemical, biophysical, mutational and structural studies, we quantitatively assess how phosphorylation of MOB1A regulates its interaction with both MST kinases and LATS/NDR family kinases in vitro.
In this study, we investigated the mechanisms behind the recruitment of MST1 and MST2 kinases to MOB1, which facilitate signal transmission in the Hippo pathway by bringing the MST1 and MST2 kinases in close vicinity to their substrates, the LATS family kinases.
Mst1-induced defective mitophagy evoked cellular oxidative stress, energy metabolism and calcium overload. Through excessive mitochondrial fission and aberrant mitophagy, Mst1 launched caspase 9-related mitochondrial apoptosis and abrogated F-actin/lamellipodium-dependent cellular migration.
Findings indicate that long-term exposure to IM results in dysregulation of stem cell renewal-regulatory Hippo (MST1/2)/YAP (zeige YAP1 ELISA Kits) signaling, and that inhibition of miR (zeige MLXIP ELISA Kits)-181a using a microRNA sponge inhibitor resulted in decreased transcription of SOX2 (zeige SOX2 ELISA Kits) and SALL4 (zeige SALL4 ELISA Kits).
These data suggest that MSP (zeige MSMB ELISA Kits) is an effective inhibitor of inflammation and lipid accumulation in the stressed liver, thereby indicating that MSP (zeige MSMB ELISA Kits) has a key regulatory role in non-alcoholic steatohepatitis.
Study found that MST1 is strongly activated in a diabetic beta cell and induces not only its death but also directly impairs insulin (zeige INS ELISA Kits) secretion through promoting proteasomal degradation of key beta cell transcription factor, pancreatic and duodenal homeobox 1 (PDX1 (zeige PDX1 ELISA Kits)), which is critical for insulin (zeige INS ELISA Kits) production.
deacetylation of MST1 mediated by HBXIP-enhanced HDAC6 results in MST1 degradation in a chaperone-mediated autophagy (CMA) manner in promotion of breast cancer growth.
TNFAIP8 regulates Hippo (MST1/2) signaling through its interaction with LATS1.
Data suggest that Hippo (MST1/2 protein kinases) - Yes associated protein 1 (YAP (zeige YAP1 ELISA Kits)) pathway involved in carcinogenesis of pancreatic cancer and in the inhibition effect of stiehopus japonieus acidic mucopolysaccharide (SJAMP) to the proliferation of pancreatic cancer cell.
The results suggest that melatonin alleviates cardiac remodeling and dysfunction in diabetic cardiomyopathy by upregulating autophagy, limiting apoptosis, and modulating mitochondrial integrity and biogenesis. The mechanisms are associated with Mst1/Sirt3 (zeige SIRT3 ELISA Kits) signaling.
These data suggest that MSP is an effective inhibitor of inflammation and lipid accumulation in the stressed liver, thereby indicating that MSP has a key regulatory role in non-alcoholic steatohepatitis.
kinases, including Slk (zeige SLK ELISA Kits), Lok and Mst1, are inhibited by BI-D1870 but to a much lesser extent by BIX 02565 and that phosphorylation of some of their substrates is blocked by BI-D1870 in living cells.
Nicorandil alleviates post-MI cardiac dysfunction and remodeling. The mechanisms were associated with enhancing autophagy and inhibiting apoptosis through Mst1 inhibition.
Using a standard two-thirds partial hepatectomy (PH) model in young and aged mice, the activity of the core kinases MST1 and LATS1 increased during the early hypertrophic phase and returned to steady state levels in the proliferative phase, coinciding with activation of YAP1 (zeige YAP1 ELISA Kits) target genes and hepatocyte proliferation.
The MST1 acts as a molecular brake to maintain immune tolerance by regulating T cell-mediated B cell activation (zeige BLNK ELISA Kits).
Mst1 knockout alleviated while Mst1 overexpression aggravated cardiac dysfunction in diabetes.
these findings highlight a role for MST1 in vesicle trafficking and extravasation in neutrophils, providing an additional mechanistic explanation for the severe immune defect
Results identify L-plastin as a key effector of Mst1 and establish a novel mechanism linking a signaling intermediate to an actin-binding protein critical to T cell migration.
MIST1 is a scaling factor necessary and sufficient by itself to induce and maintain secretory cell architecture
The protein encoded by this gene contains four kringle domains and a serine protease domain, similar to that found in hepatic growth factor. Despite the presence of the serine protease domain, the encoded protein may not have any proteolytic activity. The receptor for this protein is RON tyrosine kinase, which upon activation stimulates ciliary motility of ciliated epithelial lung cells. This protein is secreted and cleaved to form an alpha chain and a beta chain bridged by disulfide bonds.
, STE20-like kinase MST1
, dJ211D12.2 (serine/threonine kinase 4 (MST1, KRS2))
, kinase responsive to stress 2
, mammalian STE20-like protein kinase 1
, mammalian sterile 20-like 1
, serine/threonine-protein kinase 4
, serine/threonine-protein kinase Krs-2
, hepatocyte growth factor-like protein
, hepatocyte growth factor-like protein homolog
, macrophage-stimulating protein
, E2F transcription factor 2
, macrophage stimulatory protein
, hepatocyte growth factor-like/macrophage stimulating protein
, macrophage stimulating 1 (hepatocyte growth factor-like)
, 12S E1A
, macrophage stimulating 1 L homeolog