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MONDOA forms heterodimers with MLX (MIM 602976) that can bind to and activate transcription from CACGTG E boxes (Billin et al., 2000 [PubMed 11073985]).[supplied by OMIM, Mar 2008].. Zusätzlich bieten wir Ihnen MLX Interacting Protein Antikörper (32) und MLX Interacting Protein Proteine (4) und viele weitere Produktgruppen zu diesem Protein an.
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MondoA-directed programs have a key role in the coordinated control of myocyte lipid balance and insulin (zeige INS ELISA Kits) signaling
Evaluation of the conservation of ChREBP and MondoA sequences demonstrate that MondoA is better conserved and potentially mediates more ancient function in glucose metabolism.
These results suggest that C771G polymorphism of MLXIPL gene is associated with coronary stenosis and its severity.
Knockdown of MondoA, or its dimerization partner Mlx, blocks Myc (zeige MYC ELISA Kits)-induced reprogramming of multiple metabolic pathways, resulting in apoptosis
regulatory relationship between mTOR (zeige FRAP1 ELISA Kits) and the MondoA-TXNIP (zeige TXNIP ELISA Kits) axis that we propose contributes to glucose homeostasis
Suppression of Txnip (zeige TXNIP ELISA Kits) by lipopolysaccharide is accompanied by a decrease of the glucose sensing transcription factor MondoA in the nuclei.
An important contribution of MondoA to leukemia aggressiveness, which makes MondoA a potential candidate for targeted treatment of acute lymphoblastic leukemia.
the MondoA-TXNIP (zeige TXNIP ELISA Kits) regulatory circuit has a role in the hexose transport curb, although other redundant pathways also contribute
Induction of TXNIP (zeige TXNIP ELISA Kits) under lactic acidosis is caused by the activation of the glucose-sensing helix-loop-helix transcriptional complex MondoA:Mlx, which is usually triggered upon glucose exposure.
Glucose is required at two additional steps to stimulate the transcription activation function of MondoA-Mlx complexes.
MondoA is a basic helix-loop-helix/leucine zipper transcription factor (zeige NRL ELISA Kits) that is expressed predominantly in skeletal muscle. Mice deficient for MondoA excel in sprinting, as their skeletal muscles display an enhanced glycolytic capacity.
MondoA-Mlx complexes sense elevated levels of G6P and adenine nucleotides to trigger a TXNIP (zeige TXNIP ELISA Kits)-dependent feedback inhibition of glycolysis
MONDOA forms heterodimers with MLX (MIM 602976) that can bind to and activate transcription from CACGTG E boxes (Billin et al., 2000
MLX interacting protein
, MLX-interacting protein-like
, MLX-interacting protein
, Mlx interactor
, class E basic helix-loop-helix protein 36
, transcriptional activator MondoA