MDS1 and EVI1 Complex Locus Proteine (MECOM)

Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. Zusätzlich bieten wir Ihnen MDS1 and EVI1 Complex Locus Antikörper (126) und und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
MECOM 2122 Q03112 , Q13465
MECOM 14013 Q9Z1L8
Ratte MECOM MECOM 294924  
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Top MDS1 and EVI1 Complex Locus Proteine auf antikoerper-online.de

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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
$13,984.89
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Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
$13,984.89
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Escherichia coli (E. coli) Human His tag 0.5 mg Anmelden zum Anzeigen 13 bis 16 Tage
$953.85
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Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
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MECOM Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
,
Mouse (Murine)

Weitere Proteine zu MDS1 and EVI1 Complex Locus (MECOM) Interaktionspartnern

Human MDS1 and EVI1 Complex Locus (MECOM) Interaktionspartner

  1. High EVI1 expression predicts poor outcome in Acute myeloid leukemia (zeige BCL11A Proteine) with intermediate cytogenetic risk in patients receiving chemotherapy.

  2. The relationship between EVI1 and microRNAs in human malignancies. [review]

  3. Fisher's exact SubID was used to reveal EVI1 as a transcriptional regulator of INPP4B in AML; a finding which was validated in vitro. Next, we used CoxPH SubID to conduct a pan-cancer analysis of INPP4B's prognostic significance

  4. Letter/Case Report: ETV6 (zeige ETV6 Proteine)/MECOM gene fusion in therapy-related acute myeloid leukemia (zeige BCL11A Proteine) with t(3;12) and monosomy 7.

  5. These findings highlight a novel mechanism for hepatitis B virus X-induced hepatocarcinogenesis through transcription factor EVI1 and its target lncRNAs

  6. Findings represent the first global genome-wide study of EVI1 DNA binding associated with whole transcriptome expression analysis. Results reveal several important genes with an ETS (zeige ETS1 Proteine)-like binding motif, is involved in terminal myeloid differentiation, cell cycle regulation and apoptosis

  7. The expression of EVI1 and SOX9 (zeige SOX9 Proteine) is associated with stem cell-like and metastasis signatures, and their depletion impairs the metastatic potential of breast cancer cells. These results establish the mechanistic link between resistance to mTOR (zeige FRAP1 Proteine) inhibition and cancer metastatic potential, thus enhancing our understanding of mTOR (zeige FRAP1 Proteine) targeting failure

  8. EVI1 contributes to PCa (zeige FLVCR1 Proteine) progression by regulating different oncogenic functions. EVI1 regulates the PCa (zeige FLVCR1 Proteine) stem cell compartment responsible for disease initiation and also development of CRPC.

  9. oncogenic potential for EVI1 in modulating genomic stability

  10. EVI1 acts as a regulator of its own expression, highlighting the complex regulation of EVI1, and open new directions to better understand the mechanisms of EVI1 overexpressing leukemias.

Mouse (Murine) MDS1 and EVI1 Complex Locus (MECOM) Interaktionspartner

  1. These findings highlight a novel mechanism for hepatitis B virus X-induced hepatocarcinogenesis through transcription factor EVI1 and its target lncRNAs

  2. Gata2 (zeige GATA2 Proteine) heterozygous deletion confers selective advantage to EVI1-expressing leukemia cell expansion in recipient mice

  3. EVI1 acts as a regulator of its own expression, highlighting the complex regulation of EVI1, and open new directions to better understand the mechanisms of EVI1 overexpressing leukemias.

  4. the DNA sequences to which EVI1 binds at +35 and +37 kb and show that mutation of one of these releases Cebpa (zeige CEBPA Proteine) from EVI1-induced suppression.

  5. Evi1(+)DA-3 cells modified to express an intracellular form of GM-CSF (zeige CSF2 Proteine), acquired growth factor independence and transplantability and caused an overt leukemia in syngeneic hosts, without increasing serum GM-CSF (zeige CSF2 Proteine) levels.

  6. Survivin partially regulates HSC (zeige FUT1 Proteine) function by modulating the Evi-1 transcription factor and its downstream targets

  7. Thrombopoietin (zeige THPO Proteine)/MPL (zeige MPL Proteine) signaling confers growth and survival capacity to CD41-positive cells in a mouse model of Evi1 leukemia.

  8. Prdm16 (zeige PRDM16 Proteine) and Prdm3 control postnatal BAT (zeige BAAT Proteine) identity and function.

  9. Mice carrying a hypomorphic Evi1 allele are embryonic viable but exhibit severe congenital heart defects.

  10. PR-domain protein ME has an essential role in mixed-lineage leukemia (MLL (zeige MLL Proteine)) fusion protein (MFP) leukemia

Zebrafish MDS1 and EVI1 Complex Locus (MECOM) Interaktionspartner

  1. nephrogenesis in zebrafish is regulated by interactions between retinoic acid, mecom, and Notch (zeige NOTCH1 Proteine) signaling

  2. Prdm3 and prdm16 (zeige PRDM16 Proteine) are strongly expressed in the pharyngeal arches during cranioskeletal development, and their knockdown leads to defects in both the viscerocranium and the neurocranium.

Xenopus laevis MDS1 and EVI1 Complex Locus (MECOM) Interaktionspartner

  1. Evi-1 (zeige RUNX1 Proteine) is detected by in situ hybridization in the pronephric tissue, the brain and in neural crest derivatives of the head and neck

MDS1 and EVI1 Complex Locus (MECOM) Protein Überblick

Protein Überblick

The protein encoded by this gene is a transcriptional regulator and oncoprotein that may be involved in hematopoiesis, apoptosis, development, and cell differentiation and proliferation. The encoded protein can interact with CTBP1, SMAD3, CREBBP, KAT2B, MAPK8, and MAPK9. This gene can undergo translocation with the AML1 gene, resulting in overexpression of this gene and the onset of leukemia. Several transcript variants encoding a few different isoforms have been found for this gene.

Genbezeichner und Symbole assoziert mit MECOM

  • MDS1 and EVI1 complex locus (MECOM)
  • MDS1 and EVI1 complex locus (Mecom)
  • MDS1 and EVI1 complex locus (mecom)
  • MDS1 and EVI1 complex locus L homeolog (mecom.L)
  • AML1-EVI-1 Protein
  • D630039M04Rik Protein
  • evi-1 Protein
  • evi1 Protein
  • im:7140716 Protein
  • Jbo Protein
  • Mds Protein
  • Mds1 Protein
  • Mds1-Evi1 Protein
  • mecom Protein
  • mecom-a Protein
  • mecom-b Protein
  • prdm3 Protein
  • xEvi-1 Protein
  • Znfpr1b1 Protein

Bezeichner auf Proteinebene für MECOM

AML1-EVI-1 fusion protein , MDS1 and EVI1 complex locus protein EVI1 , MDS1 and EVI1 complex locus protein MDS1 , ecotropic virus integration site 1 protein homolog , myelodysplasia syndrome-associated protein 1 , oncogene EVI1 , zinc finger protein Evi1 , ecotropic viral integration site 1 , ecotropic virus integration site 1 protein , myelodysplasia syndrome 1 homolog , myelodysplasia syndrome 1 protein homolog , PR domain containing 3 , MDS1 and EVI1 complex locus , MDS1 and EVI1 complex locus protein EVI1-like , MDS1 and EVI1 complex locus protein EVI1-A , ecotropic virus integration site 1 protein homolog-A , myelodysplasia syndrome 1-ectopic viral integration site 1

GENE ID SPEZIES
2122 Homo sapiens
424997 Gallus gallus
532209 Bos taurus
14013 Mus musculus
497407 Danio rerio
460837 Pan troglodytes
488148 Canis lupus familiaris
698603 Macaca mulatta
100343228 Oryctolagus cuniculus
100403987 Callithrix jacchus
100591579 Nomascus leucogenys
294924 Rattus norvegicus
734157 Xenopus laevis
Ausgewählte Anbieter für MDS1 and EVI1 Complex Locus Proteine (MECOM)
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