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LRP8 encodes a member of the low density lipoprotein receptor (LDLR) family. Zusätzlich bieten wir Ihnen LRP8 Kits (14) und LRP8 Proteine (10) und viele weitere Produktgruppen zu diesem Protein an.
Showing 10 out of 93 products:
Chicken Polyclonal LRP8 Primary Antibody für ICC, IF - ABIN151639
Wang, Moerman-Herzog, Slaton, Barger: Presenilin 1 mutations influence processing and trafficking of the ApoE receptor apoER2. in Neurobiology of aging 2016
Show all 2 Pubmed References
Human Monoclonal LRP8 Primary Antibody für ELISA, WB - ABIN563474
Liu, Wu, Baysarowich, Kavana, Addona, Bierilo, Mudgett, Pavlovic, Sitlani, Renger, Hubbard, Fisher, Zerbinatti: PCSK9 is not involved in the degradation of LDL receptors and BACE1 in the adult mouse brain. in Journal of lipid research 2010
This study elucidates that the contracted-open conformation of ligand-bound ApoER2 at neutral pH resembles the contracted-closed conformation of ligand-unbound low-density lipoprotein receptor (zeige LDLR Antikörper) at acidic pH in a manner suggestive of being primed for ligand release even prior to internalization.
LRP8 is a risk gene for psychosis.
These results reveal an association between ApoER2 isoform expression and Alzheimer's disease.
The presence of reelin (zeige RELN Antikörper) was elevated in junctional areas as in dysplastic nevi. VLDLR (zeige VLDLR Antikörper) presented positive values in 16 cases (16/ 32) and ApoER2 was weak positive in 7 cases.
ApoER2 contributes cooperatively with endothelial cell protein C receptor (zeige PROCR Antikörper) and protease activated receptor 1 (zeige F2R Antikörper) to APC (zeige APC Antikörper)-initiated endothelial antiapoptotic and barrier protective signaling.
two SNPs (rs3737984 and rs2297660) in ApoER2 gene had significant association with dyslipidemia in Thai ethnic
A novel TACGC risk haplotype in the LRP8 gene that is present in patients with CAD (zeige CAD Antikörper) and MI but not in normal controls.
results of this study demonstrated the presence of reelin (zeige RELN Antikörper), its receptors VLDLR (zeige VLDLR Antikörper) and ApoER2 as well as Dab1 (zeige DAB1 Antikörper) in the ENS and might indicate a novel role of the reelin (zeige RELN Antikörper) system in regulating neuronal plasticity and pre-synaptic functions in the ENS.
Data suggest that PS1 (zeige PSEN1 Antikörper)/gamma-secretase-dependent processing of the reelin (zeige RELN Antikörper) receptor ApoER2 inhibits reelin (zeige RELN Antikörper) expression and may regulate its signaling.
ectopic expression of HIC1 (zeige HIC1 Antikörper) in U2OS and MDA-MB-231 cell lines decreases expression of the ApoER2 and VLDLR (zeige VLDLR Antikörper) genes, encoding two canonical tyrosine kinase (zeige TXK Antikörper) receptors for Reelin (zeige RELN Antikörper).
A1-A1, which is a soluble analog of ApoER2 that binds pathological beta2GPI/anti-beta2GPI complexes, has a positive impact on hemodynamics in lupus-prone mice with spontaneous anti-beta2GPI antibodies and hypertension
findings indicate that impaired processing or localization of apoER2 may contribute to the pathogenic effects of familial Alzheimer's disease mutations in PS1 (zeige PSEN1 Antikörper)
reveals a novel function for Reelin (zeige RELN Antikörper)/ApoER2 in peripheral nervous system, inducing cell migration of Schwann cells, a process relevant for peripheral nervous system development and regeneration
total levels of ApoER2 and surface levels of ApoER2 are increased by active Fyn (zeige FYN Antikörper)
This study demonstrated that ApoER2 is expressed in distinct spatiotemporal patterns in developing mouse cerebral cortex.
This study demonistrated that LRP8-Reelin (zeige RELN Antikörper)-Regulated Neuronal Enhancer Signature Underlying Learning and Memory Formation in mice.
Apoer2 lacking exon 16, the O-linked sugar domain, altered the proteolytic processing and abundance of Apoer2 in cells and synapse number and function in mice, hippocampal spine density, LTP (zeige SCP2 Antikörper), and cued fear learning.
genetic variants of apoE (zeige APOE Antikörper) and ApoER2 impact cardiovascular health by differentially modulating endothelial function.
Study shows that the levels of hippocampal ApoE (zeige APOE Antikörper) receptors Lrp1 (zeige LRP1 Antikörper) and Apoer2 in vivo are affected isoform specifically by ApoE4 and that the type of receptor affected is context dependent
Tandem Sepp1 (zeige SEPP1 Antikörper)-apoER2 interactions supply selenium for maintenance of brain neurons both at the blood-brain barrier and within the brain. Sepp1 (zeige SEPP1 Antikörper) inside the blood-brain barrier is taken up by neurons via apoER2, concentrating brain selenium in them.
genetic variants of apoE (zeige APOE Antikörper) and ApoER2 impact cardiovascular health by differentially modulating endothelial function.[ApoER2]
the differential expression patterns of LRP8 mRNA during final follicular growth and ovulation
This gene encodes a member of the low density lipoprotein receptor (LDLR) family. Low density lipoprotein receptors are cell surface proteins that play roles in both signal transduction and receptor-mediated endocytosis of specific ligands for lysosomal degradation. The encoded protein plays a critical role in the migration of neurons during development by mediating Reelin signaling, and also functions as a receptor for the cholesterol transport protein apolipoprotein E. Expression of this gene may be a marker for major depressive disorder. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
, low density lipoprotein receptor-related protein 8
, low-density lipoprotein receptor-related protein 8-like
, ApoE receptor 2
, low-density lipoprotein receptor-related protein 8
, apolipoprotein E receptor 2
, low density lipoprotein receptor relative, 8 ligand binding repeats, brain