anti-Leucine Proline-Enriched Proteoglycan (Leprecan) 1 (LEPRE1) Antikörper

LEPRE1 encodes an enzyme that is a member of the collagen prolyl hydroxylase family. Zusätzlich bieten wir Ihnen LEPRE1 Kits (7) und LEPRE1 Proteine (6) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
LEPRE1 64175 Q32P28
Anti-Ratte LEPRE1 LEPRE1 114200 Q9R1J8
LEPRE1 56401 Q3V1T4
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Top anti-LEPRE1 Antikörper auf antikoerper-online.de

Showing 10 out of 51 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Maus Unkonjugiert WB LEPRE1 MaxPab polyclonal antibody. Western Blot analysis of LEPRE1 expression in human placenta. Western Blot analysis of LEPRE1 expression in transfected 293T cell line by LEPRE1 MaxPab polyclonal antibody.Lane 1: LEPRE1 transfected lysate(42.9 KDa).Lane 2: Non-transfected lysate. 50 μg Anmelden zum Anzeigen 11 bis 12 Tage
$440.00
Details
Human Maus Unkonjugiert IF, IHC (p), ELISA, WB Immunoperoxidase of monoclonal antibody to LEPRE1 on formalin-fixed paraffin-embedded human esophagus. [antibody concentration 6 ug/ml] Immunofluorescence of monoclonal antibody to LEPRE1 on HeLa cell. [antibody concentration 10 ug/ml] 100 μg Anmelden zum Anzeigen 11 bis 12 Tage
$440.00
Details
Human Kaninchen Unkonjugiert ICC, IF, IHC, IHC (p), WB Western Blot: LEPRE1 Antibody [NBP2-30424] - Lane 1: Marker [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11 Lane 2: Human cell line RT-4 Lane 3: Human cell line U-251MG sp Immunohistochemistry: LEPRE1 Antibody [NBP2-30424] - Immunohistochemical staining of human vulva/anal skin shows positivity in fibroblasts. 0.1 mL Anmelden zum Anzeigen 7 bis 9 Tage
$491.63
Details
Human Maus Unkonjugiert ELISA, IF, IHC, IHC (p), WB 100 μg Anmelden zum Anzeigen 11 bis 14 Tage
$537.17
Details
Human Maus Unkonjugiert ELISA, IF, IHC, WB Immunofluorescence of monoclonal antibody to LEPRE1 on HeLa cell (antibody concentration 10 µg/mL). Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (36.63 KDa) . Dilution: 1:500~1000 100 μg Anmelden zum Anzeigen 8 bis 11 Tage
$461.00
Details
Human Maus Unkonjugiert FACS, WB HEK293T cells transfected with either RC222535 overexpress plasmid (Red) or empty vector control plasmid (Blue) were immunostained by anti-LEPRE1 antibody (ABIN2455936), and then analyzed by flow cytometry. HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY LEPRE1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-LEPRE1. 0.1 mL Anmelden zum Anzeigen Verfügbar
$451.00
Details
Human Maus Unkonjugiert FACS, IF, WB HEK293T cells transfected with either RC222535 overexpress plasmid (Red) or empty vector control plasmid (Blue) were immunostained by anti-LEPRE1 antibody (ABIN2455943), and then analyzed by flow cytometry. Anti-LEPRE1 mouse monoclonal antibody (ABIN2455943) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY LEPRE1 (RC222535). 0.1 mL Anmelden zum Anzeigen Verfügbar
$451.00
Details
Human Maus Unkonjugiert FACS, IHC, IHC (p), WB 100 μL Anmelden zum Anzeigen 11 bis 14 Tage
$507.83
Details
Human Kaninchen Unkonjugiert WB Western blot analysis of extract of various cells, using LEPRE1 antibody. 100 μL Anmelden zum Anzeigen 16 Days
$334.77
Details
Human Maus Unkonjugiert FACS, IHC, WB Flow Cytometry: LEPRE1 Antibody (1H3) [NBP2-45786] - Analysis of HEK293T cells transfected with either overexpress plasmid(Red) or empty vector control plasmid(Blue) were immunostained by LEPRE1 antibody. Immunohistochemistry: LEPRE1 Antibody (1H3) [NBP2-45786] - Analysis of Human Kidney tissue. 0.1 mL Anmelden zum Anzeigen 8 bis 11 Tage
$585.06
Details

Am meisten referenzierte anti-LEPRE1 Antikörper

  1. Human Polyclonal LEPRE1 Primary Antibody für WB - ABIN528557 : Willaert, Malfait, Symoens, Gevaert, Kayserili, Megarbane, Mortier, Leroy, Coucke, De Paepe: Recessive osteogenesis imperfecta caused by LEPRE1 mutations: clinical documentation and identification of the splice form responsible for prolyl 3-hydroxylation. in Journal of medical genetics 2009 (PubMed)
    Show all 9 Pubmed References

  2. Human Monoclonal LEPRE1 Primary Antibody für IF, IHC (p) - ABIN566242 : Cabral, Chang, Barnes, Weis, Scott, Leikin, Makareeva, Kuznetsova, Rosenbaum, Tifft, Bulas, Kozma, Smith, Eyre, Marini: Prolyl 3-hydroxylase 1 deficiency causes a recessive metabolic bone disorder resembling lethal/severe osteogenesis imperfecta. in Nature genetics 2007 (PubMed)
    Show all 4 Pubmed References

Weitere Antikörper gegen LEPRE1 Interaktionspartner

Human Leucine Proline-Enriched Proteoglycan (Leprecan) 1 (LEPRE1) Interaktionspartner

  1. P3H1 mutation is associated with Non-Lethal Type VIII (zeige COX8A Antikörper) Osteogenesis Imperfecta (zeige COL1A2 Antikörper).

  2. This study enhances our knowledge about the mutational pattern of the LEPRE1, CRTAP (zeige CRTAP Antikörper), and PPIB (zeige PPIB Antikörper) genes. LEPRE1 should be the first gene analyzed in mutation detection studies in patients with recessive OI.

  3. An additional function of the rough endoplasmic reticulum protein complex prolyl 3-hydroxylase 1.cartilage-associated protein.cyclophilin B: the CXXXC motif reveals disulfide isomerase activity in vitro.

  4. This is the first report of a mutation in LEPRE1 that eliminates only the KDEL ER-retrieval sequence, whereas other functional domains remain intact

  5. 0.4% of Mid-Atlantic African Americans and 1.48% West Africans carry mutation in LEPRE1 which causes lethal recessive osteogenesis imperfecta (zeige COL1A2 Antikörper).

  6. Mutation analyses were performed for COL1A1 (zeige COL1A1 Antikörper), COL1A2 (zeige COL1A2 Antikörper), CRTAP (zeige CRTAP Antikörper), and LEPRE1 in a cohort of 58 unrelated Chinese patients with osteogenesis imperfecta (zeige COL1A2 Antikörper).

  7. We report a large consanguineous Turkish family in which multiple individuals are affected with autosomal recessive lethal or severe osteogenesis imperfecta (zeige COL1A2 Antikörper) (OI) due to a novel homozygous LEPRE1 mutation

  8. Null mutations in LEPRE1 and CRTAP (zeige CRTAP Antikörper) cause severe recessive osteogenesis imperfecta (zeige COL1A2 Antikörper).

  9. CRTAP (zeige CRTAP Antikörper) and P3H1 are mutually stabilized in the collagen prolyl 3-hydroxylation complex in endoplasmic reticulum.

  10. Screening of 78 subjects diagnosed with osteogenesis imperfecta (zeige COL1A2 Antikörper) type II or III, identified three probands with mutations in CRTAP (zeige CRTAP Antikörper) and 16 with mutations in LEPRE1.

Mouse (Murine) Leucine Proline-Enriched Proteoglycan (Leprecan) 1 (LEPRE1) Interaktionspartner

  1. P3H1 deficiency leads to decreased deposition of extracellular matrix by osteoblasts and increased incorporation of mineral into the matrix.

  2. we generated knock-in mice carrying a single amino acid substitution in the catalytic site of P3h1 (Lepre1(H662A) ). This substitution abolished P3h1 activity but retained ability to form a complex with Crtap (zeige CRTAP Antikörper) and thus the collagen chaperone

  3. An additional function of the rough endoplasmic reticulum protein complex prolyl 3-hydroxylase 1.cartilage-associated protein.cyclophilin B: the CXXXC motif reveals disulfide isomerase activity in vitro.

  4. The LEPRE1 knockout mouse is a valuable model system to investigate the mechanism of hearing loss in recessive osteogenesis imperfecta (zeige COL1A2 Antikörper).

  5. Prolyl 3-hydroxylase 1 null mice display abnormalities in fibrillar collagen-rich tissues such as tendons, skin, and bones

  6. Study found that all 3 mouse Leprecan genes Lepre1, leprel1 (zeige LEPREL1 Antikörper) and leprel2 (zeige LEPREL2 Antikörper) are expressed in the notochord; additionally, they are expressed in dorsal root ganglia, limb buds, branchial arches, and developing kidneys.

  7. This report characterizes expression of the P3H1, P3H2 (zeige LEPREL1 Antikörper) and P3H3 (zeige LEPREL2 Antikörper) genes in embryonic and adult mice.

LEPRE1 Antigen-Profil

Protein Überblick

This gene encodes an enzyme that is a member of the collagen prolyl hydroxylase family. These enzymes are localized to the endoplasmic reticulum and their activity is required for proper collagen synthesis and assembly. Mutations in this gene are associated with osteogenesis imperfecta type VIII. Three alternatively spliced transcript variants encoding different isoforms have been described. Other variants may exist, but their biological validity has not been determined.

Genbezeichner und Symbole assoziert mit LEPRE1

  • prolyl 3-hydroxylase 1 (P3H1) Antikörper
  • prolyl 3-hydroxylase 1 (P3h1) Antikörper
  • prolyl 3-hydroxylase 1 L homeolog (p3h1.L) Antikörper
  • prolyl 3-hydroxylase 1 (p3h1) Antikörper
  • 2410024C15Rik Antikörper
  • Gros1 Antikörper
  • LEPRE1 Antikörper
  • MGC84556 Antikörper
  • OI8 Antikörper
  • P3H1 Antikörper
  • sb:cb953 Antikörper

Bezeichner auf Proteinebene für LEPRE1

growth suppressor 1 , leprecan , leucine- and proline-enriched proteoglycan 1 , prolyl 3-hydroxylase 1 , growth supressor 1 , leprecan 1 , leprecan-1 , leprecan-1 homolog , leucine- and proline-enriched proteoglycan 1 homolog , leucine proline-enriched proteoglycan (leprecan) 1 , prolyl 3-hydroxylase 1-like

GENE ID SPEZIES
64175 Homo sapiens
114200 Rattus norvegicus
414142 Gallus gallus
414447 Xenopus laevis
456811 Pan troglodytes
539976 Bos taurus
553321 Danio rerio
606980 Canis lupus familiaris
697917 Macaca mulatta
100036679 Xenopus (Silurana) tropicalis
100402370 Callithrix jacchus
100454619 Pongo abelii
100620503 Sus scrofa
56401 Mus musculus
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