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LEFTY2 encodes a member of the TGF-beta family of proteins. Zusätzlich bieten wir Ihnen LEFTY2 Proteine (11) und LEFTY2 Kits (8) und viele weitere Produktgruppen zu diesem Protein an.
Showing 10 out of 59 products:
results indicate that differential diffusivity is the major determinant of the differences in Nodal/Lefty range and provide biophysical support for reaction-diffusion models of activator/inhibitor-mediated patterning
we find that Cyclops is specifically required for the maintenance of lefty1 (zeige LEFTY1 Antikörper) and lefty2 transcription
study reports that microRNA-430 (miR (zeige MYLIP Antikörper)-430) dampens and balances the expression of the transforming growth factor-beta (TGF-beta) Nodal agonist squint and the TGF-beta (zeige TGFB1 Antikörper) Nodal antagonist lefty
results show that TET-mediated oxidation of 5-methylcytosine modulates Lefty-Nodal signalling by promoting demethylation in opposition to methylation by DNMT3A (zeige DNMT3A Antikörper) and DNMT3B (zeige DNMT3B Antikörper); findings reveal a fundamental epigenetic mechanism featuring dynamic DNA methylation (zeige HELLS Antikörper) and demethylation crucial to regulation of key signalling pathways in early body plan formation
LEFTY2 regulates the expression and activity of ENaC (zeige SCNN1A Antikörper) in endometrial epithelial cells via SGK1 (zeige SGK1 Antikörper).
Results indicate that microRNA miR (zeige MLXIP Antikörper)-127 accelerates mesendoderm differentiation of embryonic stem cells through nodal signaling by targeting left-right determination factor 2 (Lefty2).
exogenous lefty1 (zeige LEFTY1 Antikörper) administered to mice restored the endogenous expression levels of lefty1 (zeige LEFTY1 Antikörper). The present study demonstrated that lefty1 (zeige LEFTY1 Antikörper) attenuated renal interstitial injury by inhibiting the Smaddependent TGFb1 (zeige TGFB1 Antikörper) signaling pathway
Lefty-1 (zeige LEFTY1 Antikörper) may prevent TGFB1 (zeige TGFB1 Antikörper)-induced fibroblast-myofibroblast transdifferentiation in part via modulation of Smad3 (zeige SMAD3 Antikörper), JNK-3 (zeige MAPK10 Antikörper), and BMP-5 (zeige BMP5 Antikörper) signaling.
The expression of lefty in RCC (zeige XRCC1 Antikörper) cells was lower than that in adjacent non-tumor cells, which may result in the overexpression of nodal, thereby promoting the growth of RCC (zeige XRCC1 Antikörper).
Studies indicate that the pair of Nodal and Lefty (Lefty1 and Lefty2) has a conserved role in left-right asymmetry.
Taken together, these results suggest that optimal expression of Lefty1 (zeige LEFTY1 Antikörper) and Lefty2 is critical for the balanced differentiation of mESCs into three germ layers.
Beta-catenin (zeige CTNNB1 Antikörper) can recruit the H3K4me2/1 demethylase (zeige MBD2 Antikörper) LSD1 (zeige KDM1A Antikörper) to regulate the expression of the tumor suppressor Lefty1 (zeige LEFTY1 Antikörper) in mouse embryonic stem cells.
Lefty can antagonise TGF-beta1 (zeige TGFB1 Antikörper) mediated epithelial-mesenchymal transition in renal tubular epithelial cells.
LEFTY2 down-regulates MKi67 (zeige MKI67 Antikörper) expression and FAK (zeige PTK2 Antikörper) activity, up-regulates miR (zeige MLXIP Antikörper)-200a and E-cadherin (zeige CDH1 Antikörper), and is thus a powerful negative regulator of endometrial cell proliferation and migration.
Lefty A may account for the tumor suppressive activity of human adult stem cells.
Findings suggest that Lefty2 is negatively modulated by miR (zeige MLXIP Antikörper)-302s in hESCs, which plays an important role in maintaining the balance between pluripotency and germ layer specification.
findings show that the TGFB4 (ebaf) mRNA has distinct tumor specific expression
nodal and the inhibitors of Nodal signaling, lefty-A and lefty-B, are down-regulated very early upon differentiation of human embryonic stem cells
Addition of recombinant LEFTY-A to explants induced MMP-9 (zeige MMP9 Antikörper) in most samples, a response prevented by ovarian steroids.
LEFTY proteins, which are known to play a major role during mouse gastrulation, are transiently expressed during human embryonic stem cell differentiation.
This gene encodes a member of the TGF-beta family of proteins. The encoded protein is secreted and plays a role in left-right asymmetry determination of organ systems during development. The protein may also play a role in endometrial bleeding. Mutations in this gene have been associated with left-right axis malformations, particularly in the heart and lungs. Some types of infertility have been associated with dysregulated expression of this gene in the endometrium. Alternative processing of this protein can yield three different products. This gene is closely linked to both a related family member and a related pseudogene. Alternate splicing of this gene results in multiple transcript variants.
, endometrial bleeding-associated factor
, left-right determination factor A
, protein lefty-2
, protein lefty-A
, transforming growth factor beta-4
, endometrial bleeding associated factor
, left-right determination factor B
, left-right determination, factor A
, protein lefty-B
, left-right determination factor 2
, left-right determination factor 2-like