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There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. Zusätzlich bieten wir Ihnen LIMK2 Antikörper (136) und LIMK2 Proteine (10) und viele weitere Produktgruppen zu diesem Protein an.
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In turn, LIMK1 (zeige LIMK1 ELISA Kits) and LIMK2 are required for MT1-MMP (zeige MMP14 ELISA Kits)-dependent matrix degradation and cell invasion in a three-dimensional type I collagen environment.
High LIMK2 expression is associated with alcoholic hepatitis.
these results suggested that TUG1 mediates cell growth and chemoresistance of SCLC by regulating LIMK2b via EZH2 (zeige EZH2 ELISA Kits).
LIMK2 (rs149034313) is associated with Behcet's disease. The LIMK2 association is a missense variant with predicted protein damage that may influence functional interactions with proteins involved in cytoskeletal regulation by Rho GTPase (zeige RACGAP1 ELISA Kits), inflammation mediated by chemokine (zeige CCL1 ELISA Kits) and cytokine signaling pathways, T cell activation, and angiogenesis.
We observed marked increases in LIM kinase 2 (LIMK2) and cofilin 1 (CFL1 (zeige CFL1 ELISA Kits)) gene expressions in metabolic syndrome patients.
This study showed that LIMK2 messenger RNA levels was significantly upregulated in subjects with schizophrenia in laminar and cellular samples.
Actin remodelling factor LIMK2 is a key player in the ciliogenesis control network in which YAP (zeige YAP1 ELISA Kits)/TAZ (zeige TAZ ELISA Kits) and directional vesicle trafficking are integral components.
Results show that in addition to a potential role in promoting metastasis, changes in LIMK1 (zeige LIMK1 ELISA Kits) and LIMK2 expression and/or activity might contribute to AR function in prostate cancer via regulation of microtubule cytoskeletal dynamics.
results highlight the exciting possibility of combining specific LIMK2 inhibitors with anticancer drugs in the treatment of multi-drug resistant cancers
LIMK2 expression was reduced in intestinal tumours of cancer-prone mice and in human colorectal cancer cell lines and tumours. LIMK2 expression progressively decreased with advancing stage of colorectal cancer.
These data suggest that osteoblasts can increase their mechanosensitivity under continuous mechanical stimulation by reducing the actin stress fiber formation through inhibiting the LIMK2 expression.
LIMK2 expression was reduced in intestinal tumours of cancer-prone mice.
LIMK2 activity is required for keratinocyte migration in the developing eyelid.
Using RNAi against LIMK2 to inhibit the cytoskeleton reorganization can promote the expression of c-fos gene and thus enhance the mechanosensitivity of c-fos gene in osteoblasts.
Results suggest that constitutive activation of the Rho-ROCK-LIM (zeige PDLIM5 ELISA Kits) kinase pathway by extracellular production of lysophosphatidic acid by the action of autotaxin (zeige ENPP2 ELISA Kits) is required to maintain the large size of lysosomes in visceral endoderm cells.
LIMK-1 (zeige LIMK1 ELISA Kits)/2 double knockout mice were more severely impaired in both ADF/cofilin (zeige CFL1 ELISA Kits) phosphorylation and excitatory synaptic function in the CA1 (zeige CA1 ELISA Kits) region of the hippocampus.
a novel pathway emanating from the TGF-beta type I receptor (zeige TGFBR1 ELISA Kits) and leading to regulation of actin assembly, via the kinase LIMK2.
There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. The protein encoded by this gene is phosphorylated and activated by ROCK, a downstream effector of Rho, and the encoded protein, in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. It is thought that this pathway contributes to Rho-induced reorganization of the actin cytoskeleton. At least three transcript variants encoding different isoforms have been found for this gene.
, LIM domain kinase 2
, LIM domain kinase 2-like
, LIM motif-containing protein kinase 2
, LIM kinase 2
, LIM-containing protein kinase 2a
, LIM-containing protein kinase 2t
, Limk2t-1 and Limk2t-2