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Transports vesicles containing N-methyl-D-aspartate (NMDA) receptor 2B along microtubules.. Zusätzlich bieten wir Ihnen KIF17 Proteine (3) und viele weitere Produktgruppen zu diesem Protein an.
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In mammalian cells, KIF17 is dispensable for ciliogenesis and IFT-B trafficking but requires IFT-B, as well as its NLS (zeige ALDH1A2 Antikörper), for its ciliary entry across the permeability barrier located at the ciliary base.
The first evidence of an interaction between septins and a nonmitotic kinesin is provided and it is suggested that SEPT9 (zeige SEPT9 Antikörper) modulates the interactions of KIF17 with membrane cargo.
KIF17 can modify RhoA-GTPase signaling to influence junctional actin and the stability of the apical junctional complex of epithelial cells.
Expression of KIF17 in schizophrenic postmortem brains was significantly lower than controls. Both genotypic distribution and allelic frequency of rs2296225 polymorphism were significantly different between the chronic schizophrenia subjects and controls.
although EB1 (zeige MAPRE2 Antikörper) and KIF17-Tail may coordinate KIF17 catalytic activity, our data reveal a novel and direct role for KIF17 in regulating MT dynamics.
This study suggested that disruption of KIF17, although rare, could result in a schizophrenia phenotype and emphasize the possible involvement of rare de novo mutations in this disorder.
Depletion of KIF17 from cells growing in three-dimensional matrices results in aberrant epithelial cysts that fail to generate a single central lumen and to polarize apical markers.
Data show that the homodimeric kinesin-2 (zeige KIF2A Antikörper) motor KIF17 is kept in an inactive state in the absence of cargo, and define two molecular mechanisms that contribute to autoinhibition of KIF17.
The intense placental expression of KIFC1 (zeige KIFC1 Antikörper) in syncytiotrophoblast and KIF17 in vascular endothelium suggests that both proteins might be important in a cargo-transport system. KIFC1 (zeige KIFC1 Antikörper) and KIF17 expression are increased of both in preeclamptia and diabetes.
KIF17b serves as a molecular motor (zeige MYO1E Antikörper) component of a TB-RBP (zeige TSN Antikörper)-mouse ribonucleoprotein complex transporting a group of specific CREM (zeige CREM Antikörper)-regulated mRNAs.
Our findings have uncovered a hitherto unknown effector of Rab23 (zeige RAB23 Antikörper) and demonstrate how Rab23 (zeige RAB23 Antikörper) could mediate the transport of Kif17 to the primary cilium
D1-type dopaminergic receptors are delivered to cilia by a mechanism requiring the receptor cytoplasmic tail, the intraflagellar transport complex-B (IFT-B), and ciliary kinesin KIF17. This targeting mechanism critically depends on Rab23 (zeige RAB23 Antikörper).
KIF17 contributed to the development of bone cancer pain in the spinal cord through NR2B (zeige GRIN2B Antikörper) transport and mLin10 may also play a role in pain development.
findings indicated that CaMKII (zeige CAMK2G Antikörper)-mediated KIF17/NR2B (zeige GRIN2B Antikörper) trafficking may contribute to bone cancer pain, and inhibition of CaMKII (zeige CAMK2G Antikörper) may be a useful alternative or adjunct therapy for relieving cancer pain
prenatal stress significantly decreased the hippocampal KIF17 and NR2B (zeige GRIN2B Antikörper) level in offspring at postnatal stages of 3 weeks and 9 weeks, which may be related to deficits of spatial cognition caused by prenatal stress.
The results of this study suggested that phosphorylation-based regulation of NMDA receptor transport is critical for learning and memory in vivo and regulate by kif17.
This study demonistrated that KIF17 is fundamental for memory and learning via differential support of synaptic NR2A (zeige GRIN2A Antikörper)/2B levels.
NRF-1 (zeige NRF1 Antikörper) co-regulates oxidative enzymes that generate energy and neurochemicals that consume energy related to glutamatergic neurotransmission, such as KIF17, NR1 (zeige GRIN1 Antikörper), and NR2B (zeige GRIN2B Antikörper).
KIF17 contributes to neuronal events required for learning and memory by trafficking fundamental N-methyl-d-aspartate-type glutamate (zeige GRIN1 Antikörper) receptor, NR2A (zeige GRIN2A Antikörper).
ACT selectively associates with KIF17b, a kinesin highly expressed in male germ cells; The ACT-KIF17b interaction is restricted to specific stages of spermatogenesis and directly determines the intracellular localization of ACT [KIF17b]
Transports vesicles containing N-methyl-D-aspartate (NMDA) receptor 2B along microtubules.
KIF17 variant protein
, KIF3-related motor protein
, kinesin-like protein KIF17
, N-4 kinesin
, kinesin 17