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Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. Zusätzlich bieten wir Ihnen Killer Cell Immunoglobulin-Like Receptor, Two Domains, Short Cytoplasmic Tail, 3 Proteine (3) und viele weitere Produktgruppen zu diesem Protein an.
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Genotypes missing these two inhibitory KIR (zeige GEM Antikörper)-HLA combinations in addition to missing activating KIRs 2DS2 and 2DS3 were more common in Vogt-Koyanagi-Harada disease (OR = 1.90, P = 0.002).
Loss of KIR2DS3 gene is associated with breast cancer.
The genes KIR2DL5, KIR2DS3 and KIR2DS5 were present in a significantly higher proportion of individuals in the asymptomatic control group than in the malaria cases.
the presence of host genetic risk factors, IL28B (zeige IL28B Antikörper)-T and KIR2DS3 alleles, resulted in increased odds of treatment failure in these rapid virological response negative patients.
Data found that the frequencies of KIR2DS1 (zeige KIR2DS1 Antikörper), 2DS3 and 3DS1 were significantly higher in pulmonary tuberculosis patients than in the control group.
KIR2DS3 and HLA-class I (zeige MICA Antikörper) alleles (-Cw*14 and -Cw*17 (zeige SF1 Antikörper)) may play a role in the pathogenesis of the Vogt-Koyanagi-Harada disease.
The Natural Killer cell gene KIR2DS3 was significantly increased in patients with chronic hepatitis C virus infection.
Study showed that the activating KIR2DS1 (zeige KIR2DS1 Antikörper) and KIR2DS3 genes associate with fatal outcome in Ebola virus infection.
KIR2DS3 is associated with protection against acute myeloid leukemia (zeige BCL11A Antikörper).
Positive linkage disequilibrium was seen between KRI2DS2 and KIR2DS3. Positive linkage disequilibrium was seen between KIR3DS1 and KIR2DS3.
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several 'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules\\; thus, KIR proteins are thought to play an important role in regulation of the immune response.
MHC class I NK cell receptor
, killer cell immunoglobulin-like receptor 2DS3
, natural killer cell inhibitory receptor
, natural killer-associated transcript 7