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KHK encodes ketohexokinase that catalyzes conversion of fructose to fructose-1-phosphate. Zusätzlich bieten wir Ihnen Ketohexokinase Proteine (15) und Ketohexokinase Kits (8) und viele weitere Produktgruppen zu diesem Protein an.
Showing 10 out of 120 products:
Human Polyclonal KHK Primary Antibody für ELISA, WB - ABIN561590
DAmour, Agulnick, Eliazer, Kelly, Kroon, Baetge: Efficient differentiation of human embryonic stem cells to definitive endoderm. in Nature biotechnology 2005
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Human Polyclonal KHK Primary Antibody für IHC, IHC (p) - ABIN4328612
Ishimoto, Lanaspa, Le, Garcia, Diggle, Maclean, Jackman, Asipu, Roncal-Jimenez, Kosugi, Rivard, Maruyama, Rodriguez-Iturbe, Sánchez-Lozada, Bonthron, Sautin, Johnson: Opposing effects of fructokinase C and A isoforms on fructose-induced metabolic syndrome in mice. in Proceedings of the National Academy of Sciences of the United States of America 2012
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Human Polyclonal KHK Primary Antibody für WB - ABIN391089
Springer, Lindbloom-Hawley, Schermerhorn: Tissue expression of ketohexokinase in cats. in Research in veterinary science 2009
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Human Polyclonal KHK Primary Antibody für ELISA, WB - ABIN561589
Levi, Cheng, Gheysens, Patel, Chan, Wang, Namavari, Gambhir: Fluorescent fructose derivatives for imaging breast cancer cells. in Bioconjugate chemistry 2007
Cow (Bovine) Polyclonal KHK Primary Antibody für WB - ABIN2776884
Ewing, Chu, Elisma, Li, Taylor, Climie, McBroom-Cerajewski, Robinson, OConnor, Li, Taylor, Dharsee, Ho, Heilbut, Moore, Zhang, Ornatsky, Bukhman, Ethier, Sheng, Vasilescu, Abu-Farha, Lambert, Duewel et al.: Large-scale mapping of human protein-protein interactions by mass spectrometry. ... in Molecular systems biology 2007
This studies provided the first evidence that fructokinase modulates vasopressin (zeige AVP Antikörper) synthesis in the SON and secretion from the posterior pituitary into circulation.
Fructokinase knockout mice were protected from renal injury both at baseline and after high salt intake (3 wk) compared with wild-type mice. This was associated with higher levels of active (phosphorylated serine 1177) endothelial nitric oxide synthase (zeige NOS3 Antikörper) in their kidneys.
Feedforward upregulation of fructolytic and gluconeogenic enzymes specifically requires GLUT5 (zeige SLC2A5 Antikörper) and KHK and may proactively enhance the intestine's ability to process anticipated increases in dietary fructose concentrations.
Significant levels of blood fructose are maintained independent of dietary fructose, KHK, and GLUT5 (zeige SLC2A5 Antikörper), probably by endogenous synthesis of fructose.
myocardial hypoxia actuates fructose metabolism in human and mouse models of pathological cardiac hypertrophy through hypoxia-inducible factor 1alpha (HIF1alpha (zeige HIF1A Antikörper)) activation of SF3B1 (zeige SF3B1 Antikörper) and SF3B1 (zeige SF3B1 Antikörper)-mediated splice switching of KHK-A to KHK-C
Fructokinase-knockout mice with delayed hydration were protected from renal injury. Thus, recurrent dehydration can induce renal injury via a fructokinase-dependent mechanism, likely from the generation of endogenous fructose via the polyol pathway.
This study demonstrates that blocking KHK and redirecting fructose metabolism to alternative pathways is an effective way to prevent visceral obesity and insulin (zeige INS Antikörper) resistance induced by high fructose, a widespread component of Western diets.
These studies identify fructokinase as a novel mediator of diabetic nephropathy and document a novel role for endogenous fructose production, or fructoneogenesis, in driving renal disease.
High-fat and high-sucrose (western) diet induces steatohepatitis that is dependent on fructokinase.
Fructose-induced metabolic syndrome is prevented in mice lacking both fructokinase B and A but is exacerbated in mice lacking fructokinase A.
Data indicate metabolic enzymes NAD kinase (zeige NADK Antikörper) and ketohexokinase as candidate metabolic gene targets, and the chromatin remodeling protein INO80C (zeige INO80C Antikörper) as a tumor suppressor in KRAS(MUT (zeige MUT Antikörper)) colorectal tumor xenograft.
Angelica archangelica, Garcinia mangostana, Petroselinum crispum, and Scutellaria baicalensis were the top four botanical candidiates identified with inhibitory activity against ketohexokinase-C.
compared with normal hepatocytes, hepatocellular carcinoma (HCC (zeige FAM126A Antikörper)) cells markedly reduce the rate of fructose metabolism and the level of reactive oxygen species, as a result of a c-Myc (zeige MYC Antikörper)-dependent and heterogeneous nuclear ribonucleoprotein (zeige PCBP2 Antikörper) (hnRNP (zeige HNRNPC Antikörper)) H1- and H2-mediated switch from expression of the high-activity fructokinase (KHK)-C to the low-activity KHK-A isoform.
myocardial hypoxia actuates fructose metabolism in human and mouse models of pathological cardiac hypertrophy through hypoxia-inducible factor 1alpha (HIF1alpha (zeige HIF1A Antikörper)) activation of SF3B1 (zeige SF3B2 Antikörper) and SF3B1 (zeige SF3B2 Antikörper)-mediated splice switching of KHK-A to KHK-C
This study determined if single nucleotide polymorphisms in genes involved in fructose transport,SLC2A2 (zeige SLC2A2 Antikörper) and SLC2A5 (zeige SLC2A5 Antikörper) and metabolism, etohexokinase affect inter-individual variability in metabolic phenotypes.
In human hepatocytes uric acid up-regulates KHK expression thus leading to the amplification of the lipogenic effects of fructose.
ketohexokinase-A serves an unknown physiologic function that remains intact in essential fructosuria.
The expression of ketohexokinase is diminished in human clear cell type of renal cell carcinoma (zeige MOK Antikörper)
Ketohexokinase-dependent metabolism of fructose induces proinflammatory mediators in proximal tubular cells.
This gene encodes ketohexokinase that catalyzes conversion of fructose to fructose-1-phosphate. The product of this gene is the first enzyme with a specialized pathway that catabolizes dietary fructose. Alternatively spliced transcript variants encoding different isoforms have been identified.
, hepatic fructokinase