Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial Proteine (IDH2)

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. Zusätzlich bieten wir Ihnen IDH2 Antikörper (120) und IDH2 Kits (16) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
IDH2 3418 P48735
IDH2 269951 P54071
IDH2 361596 P56574
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Showing 10 out of 20 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$6,749.58
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$6,749.58
Details
Wheat germ Human GST tag 2 μg Anmelden zum Anzeigen 11 bis 12 Tage
$338.33
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Insect cells (Sf9) Human His tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 11 Days
$518.10
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 11 Days
$888.80
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Hefe Arabidopsis thaliana His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,927.83
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Hefe Ratte His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$3,147.83
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Hefe Wildschwein His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$3,147.83
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Hefe Cynomolgus His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$3,147.83
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Escherichia coli (E. coli) Human His tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$672.00
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IDH2 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , , ,
, , ,
Mouse (Murine)

Rat (Rattus)

Weitere Proteine zu Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2) Interaktionspartnern

Arabidopsis thaliana Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2) Interaktionspartner

  1. Leaf IDH activity reduced by 43% in mutant

Human Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2) Interaktionspartner

  1. eason that there is a mutation in the tumor cells is associated with de novo blocking differentiation processes and development of brain cells in the development process, as evidenced by severe cerebral hypoplasia in patients with congenital forms of this mutation of IDH2

  2. Variants were identified using the Ion Torrent Variant Caller Plugin and reference genome hg19. Golden Helix's SVS software was used for variant annotation and prediction of significance. Nine samples (1.1%) from 8 patients harbored an IDH1 (3 p.R132C and 2 p.R132L) or IDH2 mutation

  3. IDH2 levels in the serum could be a new effective biomarker for the diagnosis and prognosis of non-small-cell lung cancer.

  4. The present review discusses the molecular basis of the sensitivity of IDH1/2-mutated cancers with respect to the function of mutated IDH1/2 in cellular processes and their interactions with novel IDH1/2-mutant inhibitors. Finally, lessons learned from IDH1/2 mutations for future clinical applications in IDH1/2 wild-type cancers are discussed. [review]

  5. Mutations in the IDH2 gene were found in 7.5% of cases, with a predominance of the nonsynonymous R172K and R172W mutations

  6. IDH1 or IDH2 mutations play a limited role in the development of ESCC. 2HG is potentially synthesized to high levels in the absence of IDH1 and IDH2 mutations, and this may correlate with progression of ESCCs.

  7. x-ray crystallography of mutant IDH2 binding of an inhibitor (AG-881) to an allosteric site, and compared to IDH1 allosteric site binding

  8. The role of IDH2 mutations in tumorigenesis in gliomas is reviewed.

  9. IDH2 mutations are associated with 1p/19q codeletion in diffuse adult glioma.

  10. pharmacogenetics: observations uncover a mechanism of acquired resistance to a targeted therapy and underscore the importance of 2-hydroxyglutarate production in the pathogenesis of IDH2-mutant malignancies

  11. In this review, we summarize current knowledge regarding the function of normal and mutated IDH(socitrate dehydrogenases 1 and 2 ), explain the possible mechanisms through which these mutations might drive malignant transformation of progenitor cells in the central nervous system, and provide a comprehensive review of potential treatment strategies for IDH-mutated malignancies, focusing on gliomas.

  12. We validated the presence of IDH2 R172 hotspot mutations and PIK3CA hotspot mutations in 100% and 67% of solid papillary breast carcinoma with reverse polarity tested, respectively

  13. Identification of driver and subclonal mutations in ASXL1 and IDH1/IDH2 genes in an Argentine series of patients with myelofibrosis.

  14. an overview of the biological and clinical implications of IDH1 and IDH2 mutations in acute myeloid leukemia (review).

  15. genetic association studies in population in Czech Republic: Data suggest that mutations in IDH1 and IDH2 are associated with AML (acute myeloid leukemia); IDH1/2-based monitoring of MRD (minimal residual disease) appears to have prognostic value for residual disease in AML patients.

  16. There was significant prognostic difference among the 4 glioma subtypes. Combined IDH and TERT gene mutation analysis may be useful for prognostic subgrouping. Notably, IDH1 wild-type cases can be further subdivided into TERT(+ ) or (-) subgroups with significant prognostic difference.

  17. Generation of 2-hydroxyglutarate by mutated IDH1/2 leads to the activation of mTOR by inhibiting KDM4A.

  18. Enasidenib reduces 2-hydroxyglutarate levels in patients with relapsed or refractory (R/R) acute myeloid leukemia harboring either IDH2-R140 or IDH2-R172 mutations

  19. IDH2 mutation is associated with glioma progression.

  20. No correlation between IDH1/2 mutation status and sensitivity for NAMPT inhibitors was observed. Strikingly, higher methylation of the NAPRT promoter was observed in high-grade versus low-grade chondrosarcomas. In conclusion, this study identified NAMPT as a potential target for treatment of chondrosarcoma

Mouse (Murine) Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2) Interaktionspartner

  1. The IDH2 deficiency induced endothelial inflammation via p66shc-mediated mitochondrial oxidative stress.

  2. IDH2 deficiency downregulated pro-inflammatory mediators via modulation of the ERK and NF-kappaB pathways

  3. IDH2 knock out mice exhibit a decreased susceptibility to lipopolysaccharide (LPS)-induced lung injury. Depletion of IDH2 attenuates LPS-induced inflammatory response.

  4. role in maintaining the spinal structure by affecting the homeostatic balance between osteoclasts and osteoblasts

  5. our findings highlight the role of IDH2 in skin melanogenesis in association with mitochondrial ROS and suggest unique therapeutic strategies for the prevention of skin pigmentation.

  6. Data (including data from studies using knockout mice) suggest that IDH2 plays role in modulating liver fatty acid metabolism in dietary fructose-induced NAFLD (non-alcoholic fatty liver disease). This study was conducted in female mice; previous studies suggest that women are more prone to develop metabolic syndromes in response to fructose-sweetened beverages.

  7. present study supports the central role of idh2 deficiency in inducing oxidative stress resulting from acrolein-induced disruption of mitochondrial redox status in the lung

  8. IDH2 deficiency leads to increased mitochondrial ROS levels, activation of NF-kappaB and apoptosis of IEC in DSS-induced colitis.

  9. present study, we provided a role for IDH2 in protection against UVB-induced skin damage and a new connection between IDH2 and DeltaNp63.

  10. The disruption of IDH2 attenuates age-associated hepatic steatosis by the activation of p38/cJun NH2-terminal kinase (JNK) and p53, presumably induced by the elevation of mitochondrial reactive oxygen species (ROS), which in turn resulted in the suppression of hepatic lipogenesis and inflammation via the upregulation of fibroblast growth factor 21 (FGF21) and the inhibition of NFkappaB signaling pathways.

  11. We propose that D2-HG promotes cardiac dysfunction by impairing alpha-ketoglutarate dehydrogenase and induces histone modifications in an ACL-dependent manner.Combining mathematical modeling and in vivo as well as ex vivo studies, we found that increased amounts of the oncometabolite d-2-hydroxyglutarate (D2-HG), produced by IDH2 mutant leukemic cells, cause contractile dysfunction in the heart

  12. Increased obesity resistance and insulin sensitivity in mice lacking the IDH2 gene has been documented.

  13. treatment with Mito-TEMPO, a mitochondrial-specific superoxide scavenger, recovered mitochondrial fission-fusion imbalance and blunted mitochondrial superoxide production, and reduced the IDH2 knockdown-induced decrease in MnSOD expression, eNOS phosphorylation and NO production in endothelial cells

  14. Idh2R140Q mice displayed significantly elevated 2HG levels.

  15. These data support a significant role for increased oxidative stress as a result of compromised mitochondrial antioxidant defenses in modulating life span in mice, and thus support the oxidative stress theory of aging.

  16. Findings demonstrate that IDH2 contributes to degeneration of the DA neuron in the neurotoxin model of Parkinson's Disease.

  17. IDH2 deficiency promotes mitochondrial dysfunction and cardiac hypertrophy in mice.

  18. IDH2 and NPM1 mutations synergize in the development and maintenance of acute myeloid leukemia stem-like cells.

  19. 7-Ketocholesterol inhibits isocitrate dehydrogenase 2 expression and impairs endothelial function via microRNA-144 leading to atherosclerosis.

  20. These data demonstrate the proto-oncogenic role of mutant IDH2.

Cow (Bovine) Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2) Interaktionspartner

  1. The enzyme is highly sensitive to Mg(2+) concentration in the physiological range, pointing to a potential regulatory role of [Mg(2+)] in mitochondrial energy metabolism.

Pig (Porcine) Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2) Interaktionspartner

  1. Tyr140 and Lys212 are required for the catalytic activity of porcine NADP-dependent isocitrate dehydrogenase

  2. analysis of the coenzyme binding site in the porcine mitochondrial NADP-dependent isocitrate dehydrogenase

  3. These results suggest that IDPm plays an important protective role in cadmium-induced apoptosis by maintaining cellular redox status and by protection of Grx activity.

IDH2 Protein Überblick

Protein Überblick

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with the pyruvate dehydrogenase complex.

Genbezeichner und Symbole assoziert mit IDH2

  • isocitrate dehydrogenase subunit 2 (IDH2)
  • isocitrate dehydrogenase (NADP(+)) 2, mitochondrial (IDH2)
  • isocitrate dehydrogenase 2 (NADP+), mitochondrial (Idh2)
  • isocitrate dehydrogenase (NADP(+)) 2, mitochondrial (Idh2)
  • isocitrate dehydrogenase 2 (NADP+), mitochondrial S homeolog (idh2.S)
  • isocitrate dehydrogenase 2 (NADP+), mitochondrial (idh2)
  • isocitrate dehydrogenase [NADP], mitochondrial (LOC100441867)
  • D2HGA2 Protein
  • E430004F23 Protein
  • F6P23.14 Protein
  • F6P23_14 Protein
  • ICD-M Protein
  • IDH Protein
  • Idh-2 Protein
  • IDH-II Protein
  • IDH2 Protein
  • IDHM Protein
  • IDP Protein
  • IDPm Protein
  • isocitrate dehydrogenase II Protein
  • isocitrate dehydrogenase subunit 2 Protein
  • mNADP-IDH Protein
  • NAD+ DEPENDENT ISOCITRATE DEHYDROGENASE SUBUNIT 2 Protein
  • wu:fb33c06 Protein
  • wu:fk31e05 Protein
  • wu:fq43b01 Protein
  • zgc:55485 Protein

Bezeichner auf Proteinebene für IDH2

NADP(+)-specific ICDH , isocitrate dehydrogenase [NADP], mitochondrial , oxalosuccinate decarboxylase , ICD-M , IDH , IDP , NADP+-specific isocitrate dehydrogenase , NADPH-specific isocitrate dehydrogenase , isocitrate dehydrogenase 2 (NADP+), mitochondrial , isocitrate dehydrogenase [NADP], mitochondrial-like

GENE ID SPEZIES
816218 Arabidopsis thaliana
3418 Homo sapiens
269951 Mus musculus
327669 Bos taurus
361596 Rattus norvegicus
380013 Xenopus laevis
386951 Danio rerio
397603 Sus scrofa
448026 Xenopus (Silurana) tropicalis
453645 Pan troglodytes
479043 Canis lupus familiaris
701480 Macaca mulatta
100441867 Pongo abelii
431056 Gallus gallus
100726681 Cavia porcellus
100340796 Oryctolagus cuniculus
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