anti-Insulin-Like Growth Factor 2 Receptor (IGF2R) Antikörper

IGF2R encodes a receptor for both insulin-like growth factor 2 and mannose 6-phosphate, although the binding sites for either are located on different segments of the receptor. Zusätzlich bieten wir Ihnen IGF2R Kits (34) und IGF2R Proteine (10) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
IGF2R 3482 P11717
IGF2R 16004 Q07113
IGF2R 25151  
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Top anti-IGF2R Antikörper auf antikoerper-online.de

Showing 10 out of 172 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Rind (Kuh) Maus Unkonjugiert CyTOF, ELISA, FACS, ICC, IF, IHC, IHC (p), IP, WB Immunocytochemistry/Immunofluorescence: Mannose 6 Phosphate Receptor (Cation independent) Antibody (2G11) [ABIN152673] - Mannose 6-Phosphate Receptor staining (green), F-Actin staining with Phalloidin (red) and nuclei with DAPI (blue) is shown. Cells were grown on chamber slides and fixed with formaldehyde prior to staining. Cells were probed without (control) or with or an antibody recognizing Mannose 6-Phosphate Receptor at a dilution of 1:20 over night at 4C, washed with PBS and incubated with a DyLight-488 conjugated. Immunohistochemistry: Mannose 6 Phosphate Receptor (Cation independent) Antibody (2G11) [ABIN152673] - Staining of human testis using ABIN152673 antibody at 1:100. 0.1 mL Anmelden zum Anzeigen 7 bis 9 Tage
$446.35
Details
Human Kaninchen Unkonjugiert ICC, IHC (p), WB Anti-Mannose 6 Phosphate Receptor(Cation independent) antibody, ICC ICC: HCT116 Cell Anti-Mannose 6 Phosphate Receptor(Cation independent) antibody, Western blotting All lanes: Anti Mannose 6 Phosphate Receptor (Cation independent)  at 0.5ug/ml Lane 1: HELA Whole Cell Lysate at 40ug Lane 2: JURKAT Whole Cell Lysate at 40ug Lane 3: 22RV1 Whole Cell Lysate at 40ug Lane 4: 293T Whole Cell Lysate at 40ug Predicted bind size: 274KD Observed bind size: 274KD 100 μg Anmelden zum Anzeigen 4 bis 6 Tage
$280.00
Details
Human Kaninchen Unkonjugiert ELISA, IHC, WB Western blot analysis of IGF2R using anti-IGF2R antibody .  Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each  Lane was loaded with 50ug of sample under reducing conditions.   Lane 1: human Hela whole cell lysates,  Lane 2: human U-87MG whole cell lysates,  Lane 3: human HepG2 whole cell lysates,  Lane 4: human 22RV1 whole cell lysates,  Lane 5: rat brain tissue lysates, Lane 6: mouse brain tissue lysates.  After Electrophoresis, proteins were transferred to a Nitrocellulose membrane at 150mA for 50-90 minutes. Blocked the membrane with 5% Non-fat Milk/ TBS for 1.5 hour at RT. The membrane was incubated with rabbit anti-IGF2R antigen affinity purified polyclonal antibody (Catalog # ) at 0.5 µg/mL overnight at 4°C, then washed with TBS-0.1%Tween 3 times with 5 minutes each and probed with a goat anti-rabbit IgG-HRP secondary antibody at a dilution of 1:10000 for 1.5 hour at RT. The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit (Catalog # EK1002) with Tanon 5200 system. A specific band was detected for IGF2R at approximately 300KD. The expected band size for IGF2R is at 274KD. IHC analysis of IGF2R using anti-IGF2R antibody . IGF2R was detected in paraffin-embedded section of human intestinal cancer tissue. Heat mediated antigen retrieval was performed in citrate buffer (pH6, epitope retrieval solution) for 20 mins. The tissue section was blocked with 10% goat serum. The tissue section was then incubated with 2µg/ml rabbit anti-IGF2R Antibody  overnight at 4°C. Biotinylated goat anti-rabbit IgG was used as secondary antibody and incubated for 30 minutes at 37°C. The tissue section was developed using Strepavidin-Biotin-Complex (SABC)(Catalog # SA1022) with DAB as the chromogen. 100 μg Anmelden zum Anzeigen 4 bis 6 Tage
$280.00
Details
Human Ziege Unkonjugiert BR, CyTOF, FACS, IHC, WB Detection of IGF-II R in Human Monocytes by Flow Cytometry. Human whole blood monocytes were stained with Goat Anti-Human IGF-II R Antigen Affinity-purified Polyclonal Antibody. IGF-II R in Human Placenta. IGF-II R was detected in immersion fixed paraffin-embedded sections of human placenta using 10 µ 100 μg Anmelden zum Anzeigen 8 bis 9 Tage
$441.83
Details
Human Kaninchen Unkonjugiert IF, IHC, ELISA Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using IGF2R (Ab-2484) Antibody. The picture on the right is treated with the synthesized peptide. Immunofluorescence analysis of HeLa cells, using IGF2R (Ab-2484) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$302.50
Details
Human Maus Unkonjugiert CyTOF, FACS, WB Flow Cytometry: IGF-II R/Mannose 6 Phosphate Receptor (Cation independent) Antibody (MEM-238) [ABIN269096] - Analysis using the FITC conjugate of ABIN269096. Staining of human peripheral blood monocytes following permeablisation with Leucoperm (Fix & Perm) (BUF09). Western Blot: IGF-II R/Mannose 6 Phosphate Receptor (Cation independent) Antibody (MEM-238) [ABIN269096] - Fig. 1. Western Blotting analysis (non-reducing conditions) of CD222 in whole cell lysate of JURKAT human peripheral blood T cell leukemia cell line. Lane 1: immunostaining with anti-CD222 (MEM-238) Lane 2: immunostaining with Isotype mouse IgG1 control (PPV-06). 0.1 mg Anmelden zum Anzeigen 12 bis 15 Tage
$418.10
Details
Rind (Kuh) Kaninchen Unkonjugiert IC, IF, IHC, WB   200 μL Anmelden zum Anzeigen 13 bis 14 Tage
$487.50
Details
Human Kaninchen Unkonjugiert IHC, ELISA, WB Western blot analysis of extracts from COS7 cells treated with UV 15', using IGF2R (Phospho-Ser2409) Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human brain, using IGF2R (Phospho-Ser2409) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$302.50
Details
Human Kaninchen Unkonjugiert EIA, IF, IHC (p) Immunofluorescence analysis of HeLa cells, using IGF2R Antibody. The picture on the right is treated with the synthesized peptide. Human Breast: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μL Anmelden zum Anzeigen 11 bis 13 Tage
$687.04
Details
Human Kaninchen Unkonjugiert IF, IHC, ELISA Immunohistochemistry analysis of paraffin-embedded human brain tissue, using IGF2R (Ab-2409) Antibody. The picture on the right is treated with the synthesized peptide. Immunofluorescence analysis of HeLa cells, using IGF2R (Ab-2409) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$302.50
Details

Am meisten referenzierte anti-IGF2R Antikörper

  1. Human Polyclonal IGF2R Primary Antibody für BR, CyTOF - ABIN5012919 : Tkachuk, Kiyan, Tkachuk, Kiyan, Shushakova, Haller, Dumler: Urokinase induces survival or pro-apoptotic signals in human mesangial cells depending on the apoptotic stimulus. in The Biochemical journal 2009 (PubMed)
    Show all 7 Pubmed References

  2. Cow (Bovine) Monoclonal IGF2R Primary Antibody für CyTOF, ELISA - ABIN152673 : Dintzis, Velculescu, Pfeffer: Receptor extracellular domains may contain trafficking information. Studies of the 300-kDa mannose 6-phosphate receptor. in The Journal of biological chemistry 1994 (PubMed)
    Show all 8 Pubmed References

  3. Human Monoclonal IGF2R Primary Antibody für FACS, WB - ABIN535479 : Leksa, Godar, Schiller, Fuertbauer, Muhammad, Slezakova, Horejsi, Steinlein, Weidle, Binder, Stockinger: TGF-beta-induced apoptosis in endothelial cells mediated by M6P/IGFII-R and mini-plasminogen. in Journal of cell science 2005 (PubMed)
    Show all 3 Pubmed References

  4. Human Monoclonal IGF2R Primary Antibody für FACS - ABIN536636 : Leksa, Godár, Cebecauer, Hilgert, Breuss, Weidle, Horejsí, Binder, Stockinger: The N terminus of mannose 6-phosphate/insulin-like growth factor 2 receptor in regulation of fibrinolysis and cell migration. in The Journal of biological chemistry 2002 (PubMed)
    Show all 3 Pubmed References

  5. Human Monoclonal IGF2R Primary Antibody für FACS - ABIN536635 : Gasanov, Koina, Beagley, Aitken, Hansbro: Identification of the insulin-like growth factor II receptor as a novel receptor for binding and invasion by Listeria monocytogenes. in Infection and immunity 2005 (PubMed)
    Show all 3 Pubmed References

  6. Human Polyclonal IGF2R Primary Antibody für FACS - ABIN4895819 : Mancini, Gariboldi, Taiana, Bonzi, Craparotta, Pagin, Monti: Co-targeting the IGF system and HIF-1 inhibits migration and invasion by (triple-negative) breast cancer cells. in British journal of cancer 2014 (PubMed)
    Show all 2 Pubmed References

  7. Human Monoclonal IGF2R Primary Antibody für CyTOF, FACS - ABIN269096 : El-Shewy, Lee, Obeid, Jaffa, Luttrell: The insulin-like growth factor type 1 and insulin-like growth factor type 2/mannose-6-phosphate receptors independently regulate ERK1/2 activity in HEK293 cells. in The Journal of biological chemistry 2007 (PubMed)
    Show all 2 Pubmed References

  8. Human Monoclonal IGF2R Primary Antibody für FACS, WB - ABIN192247 : Schatzlmaier, Supper, Göschl, Zwirzitz, Eckerstorfer, Ellmeier, Huppa, Stockinger: Rapid multiplex analysis of lipid raft components with single-cell resolution. in Science signaling 2015 (PubMed)
    Show all 3 Pubmed References

Weitere Antikörper gegen IGF2R Interaktionspartner

Human Insulin-Like Growth Factor 2 Receptor (IGF2R) Interaktionspartner

  1. M. tuberculosis-initiated human mannose receptor signaling regulates macrophage recognition and vesicle trafficking by gamma Fc receptors, Grb2, and SHP-1.

  2. IGF2R deletion is associated with motor speech disorders, and language delays.

  3. Heterodimers of the SNX-BAR proteins, SNX1, SNX2, SNX5, and SNX6, are the cargo-selective elements that mediate the retrograde transport of CI-MPR from endosomes to the trans-Golgi networ independently of the core retromer trimer.

  4. Sequence-dependent cargo recognition by SNX-BARs mediates retromer-independent transport of CI-MPR.

  5. These data suggest the involvement of IGF-2, IGF-1R, IGF-2R and PTEN in temporo-spatial patterning of basic cellular processes (proliferation, differentiation) during normal tooth development.

  6. Findings indicate that IGF2R expression is controlled posttranscriptionally by two factors that associate with Igf2r mRNA and suggest that miR-195 and CUGBP1 dampen IGF signaling by inhibiting IGF2R translation.

  7. Previously characterized disease-causing mutations in IGF2, IGF1R, IGF2R, or IGFALS all were found in the general population but with allele frequencies of <1:30,000.

  8. IGF2R plays a minor role in regulating the activity of IGF1R under a variety of conditions and that due to their high expression levels, IGFBPs are the dominant mechanism to regulating IGF network activation

  9. Data show one single nucleotide polymorphism (SNP) in Fox transcription factor FOXO3 (FOXO3) was significantly associated with longevity, and the six SNPs in proto-oncogene protein AKT1 (AKT1) gene and in IGF-2 Receptor (IGF-2R) gene are not.

  10. CREB plays an important role in the inhibition of IGF2R expression by binding to the IGF2R promoter and further suppresses H9c2 cardiomyoblast cell apoptosis induced by IGF2R signaling under hypoxic conditions.

  11. This study showed that Plasma IGF2R levels were positively correlated with plasma HIV viral load.

  12. IGF2R gene polymorphism and circulating IGF2R are associated with T2DM

  13. The macrophage-specific markers CD163, soluble CD163, and soluble MR are increased in septic patients.

  14. Results show that insulin-like growth factor II (IGF-II) overexpression enhanced the levels of amyloid precursor protein (APP) in SK-N-AS neuroblastoma cells.

  15. IGF2R silencing significantly enhanced the chemo-resistance of NSCLC cell lines to cisplatin treatment.

  16. Report genes involved in trafficking of the mannose 6-phosphate receptors between the trans-Golgi network, endosomes and the plasma membrane.

  17. there is no evidence that IGF2 methylation was influenced by SNPs within the IGF1, IGF1R or IGF2R genes, which lie on other chromosomes.

  18. IGF-2, IGF-2R, and IRS-2 genes polymorphisms and their combinations are associated with risk of HCC

  19. CD222 specifically controls the balance between active and inactive Lck in resting T cells, which guarantees operative T cell effector functions.

  20. Synergistic interactions were detected between SNPs, including a non-synonymous SNP, and diplotypes within IGF2R and ADAMTS19 which may contribute to POF.

Mouse (Murine) Insulin-Like Growth Factor 2 Receptor (IGF2R) Interaktionspartner

  1. After 6 weeks of environmental tobacco smoke exposure, the Sirt-1 protein level was decreased and cardiac autophagy was increased in C57BL mice. Furthermore, the IGF2R cardiac hypertrophy signaling pathway was also triggered, although cardiac apoptosis and hypertrophy were not induced.

  2. Selective M6PR down-regulation has a critical role in CD8(+) T cell survival.

  3. Expression of imprinted gene Igf2r was unregulated in haploid androgenetic/gynogenetic blastocysts.

  4. that an elevation in IGF-II receptor levels can influence the expression profiles of transcripts as well as proteins that are involved in AD pathogenesis.

  5. DNA methylation changes were noted in the Igf2r gene during chronic cystitis in a murine model.

  6. Airn expression is both necessary and sufficient to silence Igf2r throughout embryonic stem cell differentiation.

  7. The results excluded a role for spliced and unspliced Airn lncRNA products and for Airn nuclear size and location in silencing Igf2r. Instead, silencing only required Airn transcriptional overlap of the Igf2r promoter, which interferes with RNA polymerase II recruitment in the absence of repressive chromatin.

  8. mannose 6-phosphate/IGF2R knock-down in receptor-positive mouse hepatocytes causes increased cathepsin secretion as well as enhanced cell motility and invasiveness

  9. enhanced CI-MPR expression might improve the efficacy of enzyme replacement therapy in Pompe disease through enhancing receptor-mediated uptake of GAA.

  10. The interaction of sM6P/IGF2R with Plg may be an important regulatory mechanism to inhibit migration of cells using the uPA/uPAR system.

  11. Results demonstrate a novel role for IGF2R as an IFNgamma-inducible microglial protein involved in regulation of HIV and chemokine expression.

  12. Phosphatidylinositol 3-kinase (PI3K) signaling via glycogen synthase kinase-3 (Gsk-3) regulates DNA methylation of imprinted loci Dnmt3a2, and misexpression of Igf2, H19, and Igf2r

  13. The adaptor protein complex 1-mediated transport of MPR300 from endosomes to trans-Golgi network indirectly controls the recycling rate of the receptor between the plasma membrane and endosomes, as demonstrated in mu1A-adaptin-deficient fibroblasts.

  14. Unregulated expression of the imprinted genes H19 and Igf2r in mouse uniparental fetuses

  15. role of N-terminus in regulating fibrinolysis and leukocyte migration

  16. studies demonstrate functional role of insulin-like growth factor-II and its receptor in regulation of early mouse development

  17. there is not a an Mpr300- or Mpr46-dependent pathway of granzyme-mediated killing in internalization of monomeric and complexed granzyme B

  18. Alterations of the Igf2r gene may be involved in both exogenous and endogenous liver carcinogenesis with the different patterns and frequencies

  19. Deficiency of Mpr300 appears to promote cellular proliferation and tumorigenicity but not resistance to allorejection.

  20. IGF-II modulation of cathepsin D routing is IGF-II/M6P receptor mediated

Cow (Bovine) Insulin-Like Growth Factor 2 Receptor (IGF2R) Interaktionspartner

  1. suggest that the insulin like growth factor 2 receptor(IGF2R) gene polymorphisms could be useful genetic markers for dairy production traits in cattle

  2. study hypothesizes that reduced granulosa cell insulin-like growth factor II receptor expression in F2 follicles of Twinner cows may play a role in the development of 2 or more dominant follicles

  3. imprinting of Bos taurus IGF2R is similar to mouse except in placenta, which could indicate an effect of reproductive strategy

  4. Increases in CYP19A1 and FSHR mRNA expression and decreases in IGF2R mRNA expression in follicles of Twinners support the hypothesis that increased follicular development and steroidogenesis result from increased extra-ovarian IGF-1 production.

  5. Sex-sorting procedure by flow cytometry did not affect the overall DNA methylation patterns of the IGF2 and IGF2R genes, although individual variation in their methylation patterns among bulls was observed.

  6. Study demonstrates associations between IGF2R polymorphisms and growth- and body-related traits in cattle.

  7. Data describes the long-term changes to skeletal muscle growth and IGF1, 2, 1R, and 2R mRNA expression in progeny after exposure to high and low levels of maternal nutrient intake during the first two trimesters of gestation in the bovine.

  8. Expression and binding properties of mannose-6-phosphate receptors CD-MPR and CI-MPR differ during perinatal development in rat liver.

  9. the interaction between uPAR and Man-6-P/IGF2R is a low percentage binding event and that suPAR and full-length uPAR bind the Man-6-P/IGF2R by different mechanisms.

  10. Results describe the crystal structure of the N-terminal 432 residues of the cation-independent mannose 6-phosphate receptor, which encompass three out of the 15 repetitive domains of its extracytoplasmic region.

  11. crystal structure of the N-terminal 432 residues reveals the unique architecture of binding pocket and provides insight into recognition of a variety of mannose-containing sugars

  12. CI-MPR contains a third Man-6-P recognition site that is located in domain 5 and that exhibits lower affinity than the carbohydrate-binding sites present in domains 1-3 and 9

  13. The methylation at Igf-2r imprinting control region showed significant variation in tissues, such as blood, liver, brain, heart and heart, and suggested that Igf-2r imprinting was tissue-specifically regulated.

  14. The role of insulin-like growth factor 2 (IGF2) and the regulation of the IGF2 receptor (IGF2R) during follicular development were studied.

  15. Placental expression of IGF-IIR mRNA was greater for Nuclear transfer-derived than in vivo-derived embryos.

  16. study to assess the mRNA expression of IGF-I, IGF-II, IGF-IR and IGF-IIR in bovine oocytes and different stages of preimplantation embryos

  17. Variable pattern of IGF2R allelic expression in major organs such as the brain, cotyledon, heart, liver, lung, spleen, kidney and intercotyledon was observed using a G/A transition in the 3'UTR of IGF2R

Pig (Porcine) Insulin-Like Growth Factor 2 Receptor (IGF2R) Interaktionspartner

  1. IGF2R is expressed from both parental alleles although differential allelic expression may occur.

  2. A single nucleotide polymorphism was identified by short-oligonucleotide expression profiling between Meishan and white composite swine breeds.

IGF2R Antigen-Profil

Protein Überblick

This gene encodes a receptor for both insulin-like growth factor 2 and mannose 6-phosphate, although the binding sites for either are located on different segments of the receptor. This receptor functions in the intracellular trafficking of lysosomal enzymes, the activation of transforming growth factor beta, and the degradation of insulin-like growth factor 2. While the related mouse gene shows exclusive expression from the maternal allele, imprinting of the human gene appears to be polymorphic, with only a minority of individuals showing expression from the maternal allele.

Genbezeichner und Symbole assoziert mit IGF2R

  • insulin like growth factor 2 receptor (IGF2R) Antikörper
  • insulin-like growth factor 2 receptor (Igf2r) Antikörper
  • insulin like growth factor 2 receptor (igf2r) Antikörper
  • AI661837 Antikörper
  • cd222 Antikörper
  • CI-MPR Antikörper
  • cimpr Antikörper
  • m6p-r Antikörper
  • M6P/IGF2R Antikörper
  • MPR1 Antikörper
  • Mpr300 Antikörper
  • mpri Antikörper

Bezeichner auf Proteinebene für IGF2R

300 kDa mannose 6-phosphate receptor , CI Man-6-P receptor , CI-MPR , IGF-II receptor , M6P/IGF2 receptor , M6P/IGF2R , M6PR , MPR 300 , cation-independent mannose-6 phosphate receptor , cation-independent mannose-6-phosphate receptor , insulin-like growth factor II receptor , IGF-II/CI-MPR , cation-independent MPR , cation-independent mannose 6-phosphate receptor , mannose-6-phosphate receptor, cation independent , insulin-like growth factor receptor type 2 , cation-independent mannose 6 phosphate receptor , insulin-like growth factor 2 receptor

GENE ID SPEZIES
3482 Homo sapiens
16004 Mus musculus
25151 Rattus norvegicus
281849 Bos taurus
395817 Gallus gallus
397214 Sus scrofa
484067 Canis lupus familiaris
496491 Xenopus (Silurana) tropicalis
100027969 Monodelphis domestica
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