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HRK encodes a member of the BCL-2 protein family. Zusätzlich bieten wir Ihnen HRK Kits (3) und und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal HRK Primary Antibody für WB - ABIN2474088
Giroud, Bernard, Guignier, Gras, Bonaiti, Dumas: [Lack of genetic link between the HLA system and idiopathic generalized epilepsy]. in Presse médicale (Paris, France : 1983) 1991
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Human Polyclonal HRK Primary Antibody für ELISA, WB - ABIN1002403
Lockshin, Osborne, Zakeri: Cell death in the third millennium. in Cell death and differentiation 2000
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Cow (Bovine) Polyclonal HRK Primary Antibody für WB - ABIN2782598
Lucas, Milani, Butterworth, Carmell, Scott, Clark, Cohen, Varadarajan: High CIP2A levels correlate with an antiapoptotic phenotype that can be overcome by targeting BCL-XL in chronic myeloid leukemia. in Leukemia 2016
The apoptosis phenotype was partly dependent on HRK upregulation, as HRK knockdown significantly abrogated the sensitization. KDM2B (zeige KDM2B Antikörper)-silenced tumors exhibited slower growth in vivo. Taken together, our findings suggest a novel mechanism, where the key apoptosis components are under epigenetic control of KDM2B (zeige KDM2B Antikörper) in glioblastoma multiforme cells.
miR (zeige MLXIP Antikörper)-23a-3p, miR (zeige MLXIP Antikörper)-23b-3p, and miR (zeige MLXIP Antikörper)-149-5p, were downregulated by cytokines and selected for further studies. These miRNAs were found to regulate the expression of the proapoptotic Bcl-2 (zeige BCL2 Antikörper) proteins DP5 and PUMA (zeige BBC3 Antikörper) and consequent human beta-cell apoptosis.
our findings suggest that induction of the BH3-only (zeige BBC3 Antikörper) protein Hrk is a critical step in 2-ME activation of the JNK (zeige MAPK8 Antikörper)-induced apoptotic pathway, targeting mitochondria by liberating proapoptotic protein Bak (zeige BAK1 Antikörper).
SUZ12 promotes the proliferation of human EOC cells by inhibiting apoptosis and HRK is a novel SUZ12 target gene whose upregulation contributes to apoptosis induced by SUZ12 knockdown.
Diva (zeige BCL2L10 Antikörper) binds peptides derived from the BH3 domain of several other proapoptotic Bcl-2 (zeige BCL2 Antikörper) proteins, including mouse Harakiri, Bid (zeige BID Antikörper), Bak (zeige BAK1 Antikörper) and Bmf (zeige BMF Antikörper).
The BH3-only (zeige BBC3 Antikörper) protein harakiri (HRK) is transactivated by ATF4 (zeige ATF4 Antikörper) in severe hypoxia through direct binding of ATF4 (zeige ATF4 Antikörper) to the promoter region.
Data suggest that DP5 and PUMA/BBC3 (p53 up-regulated modulator of apoptosis (zeige BBC3 Antikörper)/bcl-2-binding component 3 (zeige BBC3 Antikörper)) contribute to palmitate-induced apoptosis of pancreatic beta-cells via lipotoxic endoplasmic reticulum stress.
These results are used to propose a tentative structural model of how Harakiri works.
analysis of a novel interaction between Bcl-2 (zeige BCL2 Antikörper) members Diva (zeige BCL2L10 Antikörper) and Harakiri
Hrk is involved in the induction of apoptosis in RGCs after optic nerve transection.
Hrk deficiency does not significantly attenuate the widespread apoptosis seen in the Bcl-x (zeige BCL2L1 Antikörper) (-/-) embryonic nervous system, indicating that other BH3-only (zeige BBC3 Antikörper) molecules, alone or in combination, may regulate BAX (zeige BAX Antikörper) activation in immature neurons.
DP5 plays an important role in neuronal cell death induced by axotomy and NGF (zeige NGFB Antikörper) deprivation through the regulation of mitochondrial function and caspase-3 (zeige CASP3 Antikörper) activation
These results demonstrate that HRK contributes to apoptosis signalling elicited by trophic factor withdrawal in certain neuronal populations but is dispensable for apoptosis of haematopoietic cells.
in response to PAHs, Ahr (zeige AHR Antikörper)-mediated activation of the harakiri, BCL2 interacting protein (contains only BH3 domain), was necessary for execution of cell death.
The effect of antisense oligonucleoties specific to the harakiri mRNA on spontaneous and induced defects of mouse preimplantation embryo development
This gene encodes a member of the BCL-2 protein family. Members of this family are involved in activating or inhibiting apoptosis. The encoded protein localizes to intracellular membranes. This protein promotes apoptosis by interacting with the apoptotic inhibitors BCL-2 and BCL-X(L) via its BH3 domain. Alternate splicing results in multiple transcript variants.
, BH3-interacting domain-containing protein 3
, activator of apoptosis Hrk
, activator of apoptosis harakiri
, death protein 5
, neuronal death protein DP5
, BH3 interacting (with BCL2 family) domain, apoptosis agonist
, BH3 interacting domain 3