anti-Hairless (HR) Antikörper

May act as a transcription factor that could act on to regulate one of the phases of hair growth.. Zusätzlich bieten wir Ihnen Hairless Proteine (5) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
HR 55806 O43593
HR 60563 P97609
HR 15460 Q61645
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Top anti-Hairless Antikörper auf

Showing 10 out of 33 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert WB WB Suggested Anti-HR Antibody Titration:  0.2-1 ug/ml  Positive Control:  HepG2 cell lysate 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
Rind (Kuh) Kaninchen Unkonjugiert WB WB Suggested Anti-HR Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:312500  Positive Control:  HepG2 cell lysate Rabbit Anti-HR antibody  Formalin Fixed Paraffin Embedded Tissue: Human Skin Primary antibody Concentration: 1:100 Secondary Antibody: Donkey anti-Rabbit-Cy3 Secondary Antibody Concentration: 1:200 Magnification: 20x Exposure Time: 0.5-2.0sec 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
Human Kaninchen Unkonjugiert ELISA, IF, IHC, WB 100 μL Anmelden zum Anzeigen 16 Days
Rind (Kuh) Kaninchen Unkonjugiert WB 50 μg Anmelden zum Anzeigen 7 bis 9 Tage
Human Kaninchen Unkonjugiert ELISA, IF, IHC, IHC (p) 100 μL Anmelden zum Anzeigen 7 bis 9 Tage
Human Maus Unkonjugiert IHC, IHC (p), WB Western Blot: Hairless Antibody (1D9) [NBP2-46004] - Analysis of HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY Hairless. Immunohistochemistry: Hairless Antibody (1D9) [NBP2-46004] - Analysis of Human prostate tissue. (Heat-induced epitope retrieval by Tris-EDTA, pH8.0) 0.1 mL Anmelden zum Anzeigen 8 bis 11 Tage
Human Kaninchen Unkonjugiert ELISA, WB 50 μg Anmelden zum Anzeigen 2 bis 3 Tage
Human Maus Unkonjugiert WB   100 μL Anmelden zum Anzeigen 7 bis 9 Tage
Human Kaninchen APC ELISA   200 μL Anmelden zum Anzeigen 7 bis 9 Tage
Human Kaninchen Biotin ELISA   200 μL Anmelden zum Anzeigen 7 bis 9 Tage

Weitere Antikörper gegen Hairless Interaktionspartner

Human Hairless (HR) Interaktionspartner

  1. summary of the current knowledge of hairless protein (HR) bioactions, how HR mutations may be contributing to alopecia as well as to cancer

  2. mammalian Hr is a phosphoprotein which can exert cross-talk with the p53 (zeige TP53 Antikörper) pathway with important implications for the regulation of cell proliferation and differentiation in tissues such as skin and brain where Hr is highly expressed.

  3. We have identified two recurrent missense mutations in U2HR c.1A>T (p. Met1?) and c.104A>G (p.*35Wext1263*) in two Chinese Han families with Marie Unna Hereditary Hypotrichosis.

  4. study reports two cases of Marie Unna hereditary hypotrichosis; a novel nonsense mutation of U2HR was identified in the second case, but no causative mutation in U2HR or EPS8L3 (zeige EPS8L3 Antikörper) was found in the first case

  5. we have identified a mutation, c.74C>T, in a Chinese family with MUHH, which has been previously described in a family from Hungary. Our findings therefore indicate the prevalence of this mutation in diverse populations.

  6. Findings indicate that hairless (HR) is a H3K9 demethylase (zeige MBD2 Antikörper) that regulates epidermal homeostasis via direct control of its target genes.

  7. Unliganded VDR (zeige CYP27B1 Antikörper) upregulates the expression of hairless, the gene product of which acts as a downstream comodulator to feedback-repress DKKL1 (zeige DKKL1 Antikörper) and SOSTDC1 (zeige SOSTDC1 Antikörper).

  8. deletion mutants of hairless indicate that the JmjC domain contributes to the co-repressor activity

  9. Mutations in the gene HR coding for the hairless protein are associated with an autosomal recessive form of alopecia universalis

  10. Marie Unna hereditary hypotrichosis is caused by a novel mutation (U2HR) in the human hairless transcript.

Mouse (Murine) Hairless (HR) Interaktionspartner

  1. This study examinedthe uncommon phenotype and using microarray analyses and functional studies, we found that beta-catenin was mediated by Hr. Progenitor keratinocytes from the bulge region differentiate into both epidermis and sebaceous glands, and fail to adopt the hair keratinocytes fate in the mutant scalp, due to the decreased Wnt/beta-catenin signaling in the absence of the hairless protein.

  2. HR regulates expression of genes in the MSX2 regulatory pathway, which explains abnormal hair follicle formation in Hr(Hp)/Hr(Hp) skin.

  3. Hairless is required for adipocyte differentiation.

  4. Hr loss results in a state of uncontrolled epidermal proliferation that promotes tumor development, and Hr mutant mice should no longer be considered merely hairless 'wild-type' mice

  5. regulation of Dlx3 (zeige DLX3 Antikörper) by HR affects the IRS (zeige IARS Antikörper) keratin expression, thus modulating the formation of IRS (zeige IARS Antikörper) of hair follicle.

  6. Foxe1 (zeige FOXE1 Antikörper) mRNA expression was suppressed in HR-overexpressing skin, as well as in HR-expressing keratinocytes.

  7. Hr evokes an anti-apoptotic response by disrupting a p53 (zeige TP53 Antikörper) dependent pathway involving Bcl2 (zeige BCL2 Antikörper) family members.

  8. hairless phenotype in CR rats is not allelic with mouse hairless

  9. This thyroid hormone (zeige PTH Antikörper)-regulated corepressor associates with histone deacetylases in neonatal rat brain.

  10. HR regulates the precise timing of Wnt (zeige WNT2 Antikörper) signaling required for hair follicle regeneration.

Hairless (HR) Antigen-Profil

Protein Überblick

This gene encodes a protein that is involved in hair growth. This protein functions as a transcriptional corepressor of multiple nuclear receptors, including thyroid hormone receptor, the retinoic acid receptor-related orphan receptors and the vitamin D receptors, and it interacts with histone deacetylases. The translation of this protein is modulated by multiple regulatory ORFs that exist upstream of the primary ORF. Mutations in one of these upstream ORFs, U2HR, cause Marie Unna hereditary hypotrichosis (MUHH), an autosomal dominant form of genetic hair loss. Mutations in this gene also cause autosomal recessive congenital alopecia and atrichia with papular lesions, other diseases resulting in hair loss. Two transcript variants encoding different isoforms have been found for this gene.

Genbezeichner und Symbole assoziert mit anti-Hairless (HR) Antikörper

  • HR, lysine demethylase and nuclear receptor corepressor (HR) Antikörper
  • HR, lysine demethylase and nuclear receptor corepressor (Hr) Antikörper
  • hairless (Hr) Antikörper
  • ALUNC Antikörper
  • AU Antikörper
  • ba Antikörper
  • bldy Antikörper
  • hr Antikörper
  • HSA277165 Antikörper
  • MUHH Antikörper
  • MUHH1 Antikörper
  • N Antikörper
  • rh Antikörper
  • rh-bmh Antikörper
  • rhino Antikörper

Bezeichner auf Proteinebene für anti-Hairless (HR) Antikörper

hairless homolog , protein hairless , hairless homolog (mouse) , hairless protein , protein hairless-like

55806 Homo sapiens
100053727 Equus caballus
486130 Canis lupus familiaris
785815 Bos taurus
464040 Pan troglodytes
60563 Rattus norvegicus
397617 Sus scrofa
443241 Ovis aries
574164 Macaca mulatta
100033094 Monodelphis domestica
100357019 Oryctolagus cuniculus
100451474 Pongo abelii
100478044 Ailuropoda melanoleuca
15460 Mus musculus
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