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Endogenous activator of intestinal guanylate cyclase.
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Human Polyclonal GUCA2A Primary Antibody für IHC, IHC (p) - ABIN4316471
Wilson, Lin, Li, Snook, Gong, Sato, Liu, Girondo, Rui, Hyslop, Waldman: The paracrine hormone for the GUCY2C tumor suppressor, guanylin, is universally lost in colorectal cancer. in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2014
Show all 2 Pubmed References
Both guanylin and uroguanylin (zeige GUCA2B Antikörper) trigger lipolysis in human visceral adipocytes. Given the lipolytic action of the guanylin system on visceral adipocytes, the herein reported decrease of circulating prouroguanylin concentrations in obese patients may have a role in excessive fat accumulation in obesity.
Results demonstrate that GC-C (zeige GUCY2C Antikörper) and its ligands, guanylin and uroguanylin (zeige GUCA2B Antikörper) are downregulated in ulcerative colitis (UC), and this downregulation is more significant with aggravation of the clinical condition. Therefore, the GC-C (zeige GUCY2C Antikörper) signaling pathway may be implicated in the progression of UC.
The specific cellular distribution of both GN and UGN (zeige GUCA2B Antikörper) differs between duodenum and colon and between human and rat intestines.
There is differential expression of guanylin in colorectal cancer, and the differential expression is associated with tumor stage.
The myristoylated wild-type GCAP1 (zeige GUCA1A Antikörper) was found to have the highest Ca(2 (zeige CA2 Antikörper)+) affinity and thermal stability.
guanylin as a significant marker in salivary gland tumor pathology
It is likely that gallbladder epithelial cells synthesize and release guanylin into the bile to regulate electrolyte secretion by a paracrine/luminocrine signaling pathway.
human cortical collecting duct cells are depolarized by guanylin.
Guanylin plays a role in the regulation of ion transport in the colon
guanylin is synthesized as an intrinsic peptide in epithelial cells of the hepatobiliary system and released luminally into the hepatic and cystic bile to regulate electrolyte secretion by a paracrine/luminocrine signaling pathway
GCAP-1 (zeige GUCA1A Antikörper), a Ca(2 (zeige CA2 Antikörper)+)/Mg(2 (zeige MCOLN1 Antikörper)+) sensor protein that accelerates retinal guanylyl cyclase (RetGC (zeige GUCY2D Antikörper)) in the light and decelerates it in the dark, is inactive in cation-free form.
guanylin and uroguanylin (zeige GUCA2B Antikörper) are produced by mouse intestinal epithelial cells of columnar and secretory lineage
act on the mouse kidney, in part, through a cGMP-dependent, GC-C (zeige GUCY2C Antikörper)-independent mechanism, causing significant natriuresis by renal tubular processes
These findings suggest that guanylin deficiency causes basal chloride secretion and reduced responsiveness to heat stable (zeige CD24 Antikörper) enterotoxin (STa (zeige SULT2A1 Antikörper)) in mouse proximal colon.
existence of two signaling pathways for guanylin peptides in principal cells of mouse cortical collecting duct of kidney
Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins.
guanylate cyclase activator 2A (guanylin 2, intestinal, heat-stable)
, guanylate cyclase-activating protein 1
, guanylate cyclase-activating protein I
, guanylate cyclase activator 2 (guanylin)
, guanylin-like protein
, guanylyl cyclase activating peptide I
, guanylate cyclase activator 2A (guanylin)
, guanylate cyclase activator 2 (guanylin 2, intestinal, heatstable)