anti-Guanine Nucleotide Binding Protein (G Protein) alpha 12 (GNA12) Antikörper

Human Guanine Nucleotide Binding Protein (G Protein) alpha 12 (GNA12) Interaktionspartner

1. Galpha12 plays a crucial role in human airway smooth muscle contraction via RhoA (zeige RHOA Antikörper)-dependent activation of the PI3K (zeige PIK3CA Antikörper)/ROCK axis; targeting Galpha12 signaling may elucidate novel therapeutic targets in asthma

2. the current studies provide evidence showing that c-Jun (zeige JUN Antikörper) directly binds to a consensus binding sequence within the GNA12-5' regulatory region, thereby regulating GNA12 transcription.

3. we conclude that Galpha12 protects HUVECs[ human umbilical vein endothelial cells ] from serum withdrawal-induced apoptosis by retaining miR (zeige MLXIP Antikörper)-155 expression.

4. RGS22 (zeige RGS22 Antikörper) acts as a tumor suppressor, repressing human pancreatic adenocarcinoma cell migration by coupling to GNA12/13.

5. preeclampsia is associated with decreased methylation of the GNA12 promoter

6. Data show that N-linked glycosylation of protease-activated receptor-1 (PAR1 (zeige F2R Antikörper)) at extracellular loop 2 (ECL2) controls G12 (zeige TCF3 Antikörper)/13 versus Gq G-proteins coupling specificity in response to thrombin (zeige F2 Antikörper) stimulation.

7. Significance of Galpha12 upregulation in liver tumor progression, implicating Galpha12 as an attractive therapeutic target.

8. Results show that RMP (zeige ABCA4 Antikörper) serves as a potent factor contributing to portal vein tumor thrombus by promoting IL-6 (zeige IL6 Antikörper) transcription.

9. A tyrosine residue at the C-terminus of the Galpha subunit plays an important role in controlling activation of G-protein coupled receptors.

10. Galpha12gep oncogene (zeige RAB1A Antikörper) inhibits FOXO1 (zeige FOXO1 Antikörper), which may result from the inhibition of FOXO1 (zeige FOXO1 Antikörper) de novo synthesis by miR (zeige MLXIP Antikörper)-135b in conjunction with MDM2 (zeige MDM2 Antikörper)-mediated destabilization of FOXO1 (zeige FOXO1 Antikörper).

Zebrafish Guanine Nucleotide Binding Protein (G Protein) alpha 12 (GNA12) Interaktionspartner

1. Gpr56 (zeige GPR56 Antikörper) regulates oligodendrocyte development via interactions with Galpha12/13 and RhoA (zeige RHOA Antikörper)

2. Galpha12/13 regulate epiboly by inhibiting E-cadherin activity and modulating the actin cytoskeleton.

Mouse (Murine) Guanine Nucleotide Binding Protein (G Protein) alpha 12 (GNA12) Interaktionspartner

1. Galpha12 is required for the development of kidney cysts induced by Pkd1 (zeige PKD1 Antikörper) mutation in mouse autosomal dominant polycystic kidney disease.

2. Our data reveal a previously unknown role for Galpha12 in regulating efferocytosis and that renal tubular epithelial cells require KIM-1 (zeige HAVCR1 Antikörper) to mediate this process.

3. Selective inhibition of G12 (zeige TCF3 Antikörper)/13 signaling in macrophages can augment atheroprotective B-cell populations and ameliorate atherosclerosis.

4. Gpr56 (zeige GPR56 Antikörper) regulates oligodendrocyte development via interactions with Galpha12/13 and RhoA (zeige RHOA Antikörper)

5. results suggest that KIM-1 (zeige HAVCR1 Antikörper) is an endogenous protective mechanism against renal ischemia-reperfusion injury through inhibition of Galpha12.

6. Pkd1 (zeige PKD1 Antikörper) mutation or deletion leads to the activation of Galpha12, which promotes the maturation of ADAM10 (zeige ADAM10 Antikörper) that increases the shedding of E-cadherin (zeige CDH1 Antikörper) in kidney epithelial cells.

7. Galpha12 may play an important role in promoting membrane trafficking and exocytosis for basal and thrombin (zeige F2 Antikörper)-induced vWF (zeige VWF Antikörper) secretion, in a process involving SNAP, Galpha12/13 and Galphaq (zeige GNAQ Antikörper)/11

8. Data indicate that Pyk2 (zeige PTK2B Antikörper) is a common signaling effector downstream of both G12 (zeige TCF3 Antikörper)/13 and integrin alphaIIbbeta3 signaling, which contributes to thromboxane generation.

9. PRR5L (zeige PRR5L Antikörper) degradation promotes mTORC2 (zeige CRTC2 Antikörper)-mediated PKC-delta (zeige PKCd Antikörper) phosphorylation and cell migration downstream of Galpha12 in fibroblasts and pulmonary fibrosis.

10. Expression analysis reveals that production of 5-HT7 and Galpha12 proteins in the hippocampus undergoes strong regulation with a pronounced transient increase during early postnatal stages.