Growth Differentiation Factor 11 Proteine (GDF11)

The protein encoded by GDF11 is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. Zusätzlich bieten wir Ihnen GDF11 Antikörper (69) und GDF11 Kits (47) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
GDF11 10220 O95390
GDF11 14561 Q9Z1W4
GDF11 29454  
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Top GDF11 Proteine auf

Showing 10 out of 30 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Lieferzeit Preis Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 50 Days
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 50 Days
Escherichia coli (E. coli) Human Unkonjugiert 100 μg 1 bis 2 Tage
Escherichia coli (E. coli) Human Unkonjugiert   100 μg 1 bis 2 Tage
Escherichia coli (E. coli) Human His tag,T7 tag 100 μg 15 bis 18 Tage
Escherichia coli (E. coli) Ratte His tag,T7 tag 100 μg 15 bis 18 Tage
Escherichia coli (E. coli) Human Unkonjugiert   50 μg 2 bis 3 Tage
Escherichia coli (E. coli) Human His tag 100 μg 13 bis 16 Tage
Wheat germ Human GST tag 10 μg 11 bis 12 Tage
Human Cells Human Unkonjugiert   50 μg 4 Days

GDF11 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , ,
, , ,
Mouse (Murine) ,

Rat (Rattus)

Weitere Proteine zu Growth Differentiation Factor 11 (GDF11) Interaktionspartnern

Human Growth Differentiation Factor 11 (GDF11) Interaktionspartner

  1. GDF11 inhibits adipogenic differentiation.

  2. Plasma levels of GDF11 had a higher association with body mass and body composition than muscle function in older women.

  3. Results show that GDF11 expression and activity were reduced in skin dermal fibroblasts deriving from adult donors compared to neonatal ones supporting the conclusions of GDF11 being an anti-ageing factor in humans.

  4. Serum GDF11 levels were increased and negatively correlated with Hb levels and reticulocyte counts in AA patients. This suggests an impaired GDF11 response contributing to anemia in AA patients.

  5. The serum content of GDF11 was much less in esophageal cancer patients than in the control group. Esophageal GDF II in cancer patients was correlated with cancer differentiation: the higher the degree of differentiation, the higher the content of GDF11.

  6. Physical inactivity was significantly related to the decreased GDF11 levels in COPD.

  7. GDF11 expression was decreased in COPD patients' serum and cells when compared with that of healthy people.

  8. GDF11 may be a relevant myostatin-interacting peptide to successful aging in humans

  9. The Growth Differentiation Factor 11 (GDF11) and Myostatin (MSTN) in tissue specific aging.

  10. Tumor-suppressor inactivation of GDF11 occurs by precursor sequestration in triple-negative breast cancer

  11. These studies identify distinctive structural features of GDF11 that enhance its potency, relative to GDF8; however, the biological consequences of these differences remain to be determined.

  12. In elderly Chinese women, osteoporosis risk was significantly increased with increases in GDF11 serum levels.

  13. A Prodomain Fragment from the Proteolytic Activation of Growth Differentiation Factor 11 Remains Associated with the Mature Growth Factor and Keeps It Soluble

  14. MSTN, but not GDF11, declines in healthy men throughout aging.

  15. GDF11 is highly concentrated in human platelets.

  16. The crystal structure of GDF11 was determined to a resolution of 1.50 A.

  17. GDF11 is essential for mammalian development and has been suggested to regulate aging of multiple tissues. It functions in the heart, skeletal muscle, and brain. Review.

  18. GDF11 inhibits rather than helps muscle regeneration.

  19. Show that there is no age-related cardiac hypertrophy in disease-free 24-month-old C57BL/6 mice and that restoring GDF11 in old mice has no effect on cardiac structure or function.

  20. in vitro sprout formation was increased as well by GDF11 treatment

Mouse (Murine) Growth Differentiation Factor 11 (GDF11) Interaktionspartner

  1. uncover a genetic network involving Gdf11, Lin28, and Hox13 genes controlling axial progenitor activity in the tail bud

  2. GDF11 remarkably attenuated the severity of skin inflammation in both two mice models. Additionally, the activation of nuclear NF-kappaB signaling pathway was repressed by GDF11

  3. Suppression of cell-cycle progression may be a key mechanism by which GDF11 inhibited hepatocyte regeneration.

  4. critical regulator of kidney fibrosis and tubular function

  5. study indicates that GDF11/8 in the kidney decreases with age and that GDF11 can increase tubular cell dedifferentiation and proliferation as well as improve tubular regeneration after acute kidney injury (AKI) in old mice.

  6. Our results showed that GDF11 inhibited osteoblastic differentiation of bone marrow mesenchymal stem cells in vitro and had no effect on osteoclast differentiation or bone resorption

  7. In conclusion, our findings show that GDF11 expression declines with age and the protective effects of ultrasound-targeted microbubble destruction-mediated delivery of GDF11 on the aged ischemic heart provide support for the classification of GDF11 as an anti-aging factor

  8. we found that myostatin forms a complex with LTBP4 and that overexpression of LTBP4 led to a decrease in myostatin levels. LTBP4 also interacted with TGFbeta and GDF11, a protein highly related to myostatin. These data identify LTBP4 as a multi-TGFbeta family ligand binding protein with the capacity to modify muscle disease through overexpression

  9. Circulating levels of GDF11/8 declines with age in mice (and sheep, horses and rats).

  10. Data show that circulating myostatin levels decreased with age and estimates of growth differentiation factor 11 (GDF11) levels using myostatin null mice indicate that they were almost 500 times lower than those for myostatin.

  11. Two new studies demonstrate that GDF11 this "factor of youth" rejuvenates stem cells found in the skeletal muscle and brain of aged mice.

  12. Therefore, we postulate that GDF-11DeltaEx1 may act as a long non-coding RNA to regulate the transcription of canonical GDF-11 and/or other genes in skeletal muscle and other tissues

  13. Expression of GDF11, a cytokine which blocks terminal erythroid maturation, was increased in erthyroblasts of thalassemic mice.

  14. GDF11 inhibited erythroid maturation in mice in vivo and ex vivo. Expression of GDF11 in erythroid precursors decreased progressively with maturation, suggesting an inhibitory role for GDF11 in late-stage erythroid differentiation.

  15. Gdf11 stimulates expression of a Hoxd11/lacZ transgene in the mouse embryo tailbud.

  16. GASP-1 and GASP-2 are important modulators of GDF-11 and MSTN activity in vivo.

  17. Gdf11 signaling is a major coordinator of the trunk-to-tail transition during mouse development

  18. Using modified aptamer-based proteomics, study identified the TGF-beta superfamily member GDF11 as a circulating factor in young mice that declines with age.

  19. Reducing GDF11 levels might promote restoration of retinal development in the microophthalmic Vsx2 mutant mouse.

  20. These results suggest that over-expression of BMP11 propeptide stimulates bone formation by increasing osteoblast cell functions.

Zebrafish Growth Differentiation Factor 11 (GDF11) Interaktionspartner

  1. First non-mammalian growth/differentiation factor (GDF) 11-like homolog was cloned from zebrafish. Sequencing,phylogenetic analysis,tissue expression, and mRNA levels during embryonic development are reported.

GDF11 Protein Überblick

Protein Überblick

The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in mice and Xenopus suggest that this protein is involved in mesodermal formation and neurogenesis during embryonic development.

Genbezeichner und Symbole assoziert mit GDF11

  • growth differentiation factor 11 (GDF11)
  • growth differentiation factor 11 (Gdf11)
  • growth differentiation factor 11 (gdf11)
  • BMP-11 Protein
  • Bmp11 Protein
  • GDF11 Protein

Bezeichner auf Proteinebene für GDF11

GDF-11 , bone morphogenetic protein 11 , growth/differentiation factor 11 , growth differentiation factor 11

10220 Homo sapiens
14561 Mus musculus
29454 Rattus norvegicus
406247 Danio rerio
451970 Pan troglodytes
540517 Bos taurus
100722750 Cavia porcellus
606826 Canis lupus familiaris
397254 Sus scrofa
100341680 Oryctolagus cuniculus
101104900 Ovis aries
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