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The protein encoded by GDF10 is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily.
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Human Polyclonal GDF10 Primary Antibody für WB - ABIN516005
Cheng, Hsiao, Fan, Lo, Tzen, Wu, Fang, Cheng, Chen, Chang, Jiang, Chang, Lee: Loss of GDF10/BMP3b as a prognostic marker collaborates with TGFBR3 to enhance chemotherapy resistance and epithelial-mesenchymal transition in oral squamous cell carcinoma. in Molecular carcinogenesis 2015
Study shows that GDF10 is down-regulated in patients with oral squamous cell carcinoma, and is an independent risk factor for overall survival. Its expression is regulated by TGFBR3 (zeige TGFBR3 Antikörper) which shares the signaling inhibiting epithelial-mesenchymal transition.
GDF10 is a stroke-induced signal for axonal sprouting and functional recovery.
new hypoxia-inducible and SOX9 (zeige SOX9 Antikörper)-regulated genes, Gdf10 and Chm-I (zeige LECT1 Antikörper). In addition, Mig6 (zeige ERRFI1 Antikörper) and InhbA (zeige INHBA Antikörper) were induced by hypoxia, predominantly via HIF-2alpha (zeige EPAS1 Antikörper)
BMP3b and BMP6 (zeige BMP6 Antikörper) genes were suppressed by DNA methylation (zeige HELLS Antikörper) and methylation of BMP3b is significantly frequent in Japanese malignant pleural mesotheliomas (MPMs), suggesting its pathogenic role and the ethnic difference in MPMs.
Results show that Gdf10, expressed in Bergmann glial cells, is affected by the loss of Shh (zeige SHH Antikörper) as early as E18.5, suggesting a regulation of glial development by Shh (zeige SHH Antikörper)
Here we show that Runx2 (zeige RUNX2 Antikörper) is highly expressed in lung cancer cells and downregulates BMP-3B. The ectopic expression of Runx2 (zeige RUNX2 Antikörper), but not DNA binding mutant Runx2 (zeige RUNX2 Antikörper), in normal lung fibroblast cells and lung cancer cells resulted in suppression of BMP-3B levels.
data suggest that BMP-3b is secreted from adipocytes, is involved in adipocyte differentiation, and inhibits adipogenesis as a unique complex.
Sca-1 (zeige Ly6a Antikörper) attenuated GDF10-dependent TGF-beta (zeige TGFB1 Antikörper) signaling by disrupting the heterodimerization of TbetaRI (zeige TGFBR1 Antikörper) and TbetaRII receptors.
Gdf10 is expressed in Bergmann glia and is reduced in staggerer mice.
GDF10 gene might have potential effects on body measurement traits in the above mentioned cattle populations and could be used for marker-assisted selection.
The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in mice suggest that the protein encoded by this gene plays a role in skeletal morphogenesis.
growth differentiation factor 10
, bone morphogenetic protein 3B-like
, bone morphogenetic protein 3B
, bone-inducing protein
, prepro bone inducing protein
, growth/differentiation factor 10