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Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. Zusätzlich bieten wir Ihnen Granulin Antikörper (164) und Granulin Proteine (43) und viele weitere Produktgruppen zu diesem Protein an.
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Human Granulin ELISA Kit für Sandwich ELISA - ABIN578626
Qu, Deng, Hu: Plasma progranulin concentrations are increased in patients with type 2 diabetes and obesity and correlated with insulin resistance. in Mediators of inflammation 2013
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Rat (Rattus) Granulin ELISA Kit für Sandwich ELISA - ABIN4881274
Zhou, Xie, Wang, Zhang, Chen, Zhang, Wu, Wei, Ding, Hang, Zhou, Shi: Decreased progranulin levels in patients and rats with subarachnoid hemorrhage: a potential role in inhibiting inflammation by suppressing neutrophil recruitment. in Journal of neuroinflammation 2015
Findings show that miR (zeige MYLIP ELISA Kits)-145 and GrnA expression patterns are inversely correlated during liver development and provide evidence that GrnA-dependent hepatic outgrowth is regulated by miR (zeige MYLIP ELISA Kits)-145 in zebrafish embryonic development.
the Grna and Grnb single and double knock out zebrafish lack any obvious morphological, pathological and biochemical phenotypes
GrnA positively modulates hepatic MET expression both in vivo and in vitro.
HSPA5 (GRP78 (zeige HSPA5 ELISA Kits)) and GEP were identified to interact. Clinical analysis showed that expression of GRP78 (zeige HSPA5 ELISA Kits) was up-regulated in hepatocellular carcinoma tumor and correlated with GEP expression.
the expression of PGRN was significantly upregulated in Osteonecrosis of the Femoral Head patients' articular cartilage, and recombinant PGRN could promote expression of aggrecan (zeige ACAN ELISA Kits) and collagen II and the activation of ERK1/2 (zeige MAPK1/3 ELISA Kits).
White matter hyperintensities are seen only in GRN mutation carriers in fronto-temporal dementia.
The study provides solid evidence that there is the interaction between GRN A and ENO1 (zeige ENO1 ELISA Kits) and the interaction is responsible for the effects of GRN A on glucose uptake as well as cancer cell migration and invasion.
This study ascertained that PGRN expression in airway epithelial cells inhibits CS-induced apoptosis, presumably through regulation of the ER stress response and MAPK (zeige MAPK1 ELISA Kits) activation.
mTOR (zeige FRAP1 ELISA Kits) signaling contributes to PGRN-stimulated carcinogenesis of cervical cancer
This study describe a novel GRN, p.(Tyr229*) mutation, resulting in haploinsufficiency of GRN and a severe neuropathologic FTLD phenotype.
This meta-analysis supported the T allele of rs5848 within progranulin, as a risk factor for Alzheimer's Disease.
Our case report further corroborates the notion that, in addition to FTD (zeige FTL ELISA Kits), progranulin may be involved in the neurobiology of bipolar disorder type 1, and suggests to screen patients with late-onset bipolar disorder for GRN mutations.
GRN SNPs likely influence disease course and relapse recovery in multiple sclerosis.
PGRN plays a protecting role in hippocampal neurogenesis.
This study demonstrated that Progranulin overexpression in sensory neurons attenuates neuropathic pain in mice.
The results of this study show that endogenous and recombinant PGRN limit axonal injury and astrogliosis and suggest therapeutic potential of PGRN in traumatic brain injury.
progranulin expression is critical for tumor growth in vivo, in both xenograft and orthotopic tumor models
Study demonstrate that PGRN interacts with the lysosomal protease CTSD (zeige CTSD ELISA Kits) and maintains its proper activity in vivo. Therefore, by regulating CTSD (zeige CTSD ELISA Kits) activity, PGRN may modulate protein homeostasis. This could potentially explain the TDP-43 (zeige TARDBP ELISA Kits) aggregation observed in frontotemporal lobar degeneration with GRN mutations.
Findings suggest that elevated PGRN is linked to cognitive deficits of fragile X (zeige FMR1 ELISA Kits) syndrome.
highlight an important role for neuron-derived progranulin in maintaining normal social function.
overexpression of PGRN was also found to increase activity of neprilysin (zeige MME ELISA Kits), a key amyloid beta degrading enzyme. PGRN regulation of neprilysin (zeige MME ELISA Kits) activity could play a major role in the observed alterations in plaque burden
PGRN decrease, resulting from pathogenic mutations, might compromise the trophism of cortical neurons by affecting GluN2B (zeige GRIN2B ELISA Kits)-contaning NMDA receptors
ADAM15 (zeige ADAM15 ELISA Kits) and acrogranin are present on and associated with the surface of guinea pig spermatozoa; besides both proteins may play a role during sperm-egg binding.
Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis.
, PC cell-derived growth factor