Granulin (GRN) ELISA Kits

Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif.

list all ELISA KIts Gen GeneID UniProt
Anti-Human GRN GRN 2896 P28799
Anti-Ratte GRN GRN 29143 P23785
Anti-Maus GRN GRN 14824  
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Top Granulin ELISA Kits auf antikoerper-online.de

Showing 10 out of 129 products:

Katalog Nr. Reaktivität Sensitivität Bereich Bilder Menge Anbieter Lieferzeit Preis Details
Human 1.95 pg/mL 7.8-500 pg/mL Typical standard curve 96 Tests Anmelden zum Anzeigen 13 bis 16 Tage
$910.56
Details
Maus 10pg/mL 0.78-50 ng/mL Mouse Progranulin PicoKine ELISA Kit standard curve 96 Tests Anmelden zum Anzeigen 4 bis 6 Tage
$369.00
Details
Ratte 0.065 ng/mL 0.15 ng/mL - 10 ng/mL 96 Tests Anmelden zum Anzeigen 13 bis 16 Tage
$800.00
Details
Meerschweinchen 1.0 pg/mL 50-1000 pg/mL   96 Tests Anmelden zum Anzeigen 15 bis 18 Tage
$707.14
Details
Kaninchen 1.0 pg/mL 50-1000 pg/mL   96 Tests Anmelden zum Anzeigen 15 bis 18 Tage
$707.14
Details
Huhn 1.875 ng/mL 3.125-200 ng/mL   96 Tests Anmelden zum Anzeigen 12 bis 14 Tage
$715.00
Details
Schwein 0.938 ng/mL 1.563-100 ng/mL   96 Tests Anmelden zum Anzeigen 12 bis 14 Tage
$715.00
Details
Hund 1.0 pg/mL 50-1000 pg/mL   96 Tests Anmelden zum Anzeigen 15 bis 18 Tage
$707.14
Details
Affe 1.0 pg/mL 50-1000 pg/mL   96 Tests Anmelden zum Anzeigen 15 bis 18 Tage
$707.14
Details
Schaf
  96 Tests Anmelden zum Anzeigen 15 bis 18 Tage
$707.14
Details

Am meisten referenzierte Granulin ELISA Kits

  1. Human Granulin ELISA Kit für Sandwich ELISA - ABIN578626 : Qu, Deng, Hu: Plasma progranulin concentrations are increased in patients with type 2 diabetes and obesity and correlated with insulin resistance. in Mediators of inflammation 2013 (PubMed)
    Show all 2 Pubmed References

  2. Rat (Rattus) Granulin ELISA Kit für Sandwich ELISA - ABIN4881274 : Zhou, Xie, Wang, Zhang, Chen, Zhang, Wu, Wei, Ding, Hang, Zhou, Shi: Decreased progranulin levels in patients and rats with subarachnoid hemorrhage: a potential role in inhibiting inflammation by suppressing neutrophil recruitment. in Journal of neuroinflammation 2015 (PubMed)

Weitere ELISA Kits für Granulin Interaktionspartner

Zebrafish Granulin (GRN) Interaktionspartner

  1. The data od this study suggest that Pgrn-a plays a dual role during nervous system development by governing the rate at which progenitors progress through the cell cycle and attracting microglial progenitors into the embryonic brain and retina.

  2. Findings show that miR (zeige MYLIP ELISA Kits)-145 and GrnA expression patterns are inversely correlated during liver development and provide evidence that GrnA-dependent hepatic outgrowth is regulated by miR (zeige MYLIP ELISA Kits)-145 in zebrafish embryonic development.

  3. the Grna and Grnb single and double knock out zebrafish lack any obvious morphological, pathological and biochemical phenotypes

  4. GrnA positively modulates hepatic MET expression both in vivo and in vitro.

Human Granulin (GRN) Interaktionspartner

  1. PGRN is a regulator of tumorigenesis because it stimulates cell proliferation, migration, invasion, angiogenesis, malignant transformation, resistance to anticancer drugs, and immune evasion. [review]

  2. PGRN regulated its own expression in a positive feedback loop via the AKT (zeige AKT1 ELISA Kits) and ERK (zeige EPHB2 ELISA Kits) signaling pathways.

  3. PGRN is involved in lysosomal homeostasis and lipid metabolism.

  4. High serum GP88 concentrations are associated with poor prognosis in patients with DLBCL

  5. This study showed that endogenous levels of multiple GRNs are haploinsufficient in FTD (zeige FTL ELISA Kits)-GRN patient fibroblasts and frontal cortex, mirroring full-length PGRN.

  6. HSPA5 (GRP78 (zeige HSPA5 ELISA Kits)) and GEP were identified to interact. Clinical analysis showed that expression of GRP78 (zeige HSPA5 ELISA Kits) was up-regulated in hepatocellular carcinoma tumor and correlated with GEP expression.

  7. the expression of PGRN was significantly upregulated in Osteonecrosis of the Femoral Head patients' articular cartilage, and recombinant PGRN could promote expression of aggrecan (zeige ACAN ELISA Kits) and collagen II and the activation of ERK1/2 (zeige MAPK1/3 ELISA Kits).

  8. White matter hyperintensities are seen only in GRN mutation carriers in fronto-temporal dementia.

  9. The study provides solid evidence that there is the interaction between GRN A and ENO1 (zeige ENO1 ELISA Kits) and the interaction is responsible for the effects of GRN A on glucose uptake as well as cancer cell migration and invasion.

  10. This study ascertained that PGRN expression in airway epithelial cells inhibits CS-induced apoptosis, presumably through regulation of the ER stress response and MAPK (zeige MAPK1 ELISA Kits) activation.

Mouse (Murine) Granulin (GRN) Interaktionspartner

  1. PGRN haploinsufficiency may decrease accumulation of Abeta (zeige APP ELISA Kits).

  2. that mutations resulting in progranulin is processed in the lysosome through the actions of cathepsins

  3. Results from conditional progranulin-knockout mice that lack progranulin in nestin (zeige NES ELISA Kits)-expressing cells (Nes (zeige NES ELISA Kits)-cKO mice), which include most neurons as well as astrocytes, suggest that increased lipofuscinosis and gliosis in Grn-null animals are not caused by intrinsic progranulin deficiency in neurons, and that microglia-derived progranulin may be sufficient to maintain neuronal health and homeostasis in the brain.

  4. PGRN deficiency exacerbates neuroinflammatory responses related to activated microglia in aged animals, while PGRN may not counteract the decline of hippocampal neurogenesis with age.

  5. PGRN is involved in lysosomal homeostasis and lipid metabolism.

  6. findings suggest that PGRN deficiency leads to excessive NF-kappaB (zeige NFKB1 ELISA Kits) activation in microglia and elevated TNFalpha (zeige TNF ELISA Kits) signaling, which in turn lead to hyperexcitability of medium spiny neurons and obsessive-compulsive behavior-like behavior.

  7. PGRN plays a protecting role in hippocampal neurogenesis.

  8. This study ascertained that PGRN expression in airway epithelial cells inhibits CS-induced apoptosis, presumably through regulation of the ER stress response and MAPK (zeige MAPK1 ELISA Kits) activation.

  9. This study demonstrated that Progranulin overexpression in sensory neurons attenuates neuropathic pain in mice.

  10. The results of this study show that endogenous and recombinant PGRN limit axonal injury and astrogliosis and suggest therapeutic potential of PGRN in traumatic brain injury.

Guinea Pig Granulin (GRN) Interaktionspartner

  1. ADAM15 (zeige ADAM15 ELISA Kits) and acrogranin are present on and associated with the surface of guinea pig spermatozoa; besides both proteins may play a role during sperm-egg binding.

Granulin (GRN) Antigen-Profil

Beschreibung des Gens

Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis.

Genbezeichner und Symbole assoziert mit Granulin (GRN) ELISA Kits

  • granulin precursor (GRN) Antikörper
  • granulin a (grna) Antikörper
  • Granulins (grn) Antikörper
  • granulin L homeolog (grn.L) Antikörper
  • granulin (granulin) Antikörper
  • granulin (ORF1 granulin) Antikörper
  • granulin precursor (Grn) Antikörper
  • granulin (Grn) Antikörper
  • acrogranin Antikörper
  • CLN11 Antikörper
  • DKFZp459H066 Antikörper
  • epithelin Antikörper
  • GEP Antikörper
  • GP88 Antikörper
  • grn Antikörper
  • MGC53354 Antikörper
  • PCDGF Antikörper
  • PEPI Antikörper
  • PGRN Antikörper
  • wu:fb11g12 Antikörper
  • wu:fj18f05 Antikörper

Bezeichner auf Proteinebene für Granulin (GRN) ELISA Kits

granulin , granulin-a , zfPGRN-A , Granulins , PC cell-derived growth factor , acrogranin , granulin-epithelin , granulins , proepithelin , progranulin , PCDGF , PEPI , acrogranulin

GENE ID SPEZIES
454728 Pan troglodytes
100051035 Equus caballus
791524 Danio rerio
100195018 Salmo salar
380370 Xenopus laevis
1463344 Adoxophyes orana granulovirus
2776804 Agrotis segetum granulovirus
100173689 Pongo abelii
2896 Homo sapiens
29143 Rattus norvegicus
14824 Mus musculus
480501 Canis lupus familiaris
733645 Sus scrofa
767942 Bos taurus
100135533 Cavia porcellus
100349528 Oryctolagus cuniculus
101115470 Ovis aries
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