Granulin (GRN) ELISA Kits

Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. Zusätzlich bieten wir Ihnen Granulin Antikörper (165) und Granulin Proteine (45) und viele weitere Produktgruppen zu diesem Protein an.

list all ELISA KIts Gen GeneID UniProt
GRN 2896 P28799
GRN 29143 P23785
GRN 14824  
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Top Granulin ELISA Kits auf antikoerper-online.de

Showing 9 out of 128 products:

Katalog Nr. Reaktivität Sensitivität Bereich Bilder Menge Anbieter Lieferzeit Preis Details
Human 1.95 pg/mL 7.8-500 pg/mL Typical standard curve 96 Tests Anmelden zum Anzeigen 13 bis 16 Tage
$910.56
Details
Maus 10pg/mL 0.78-50 ng/mL Mouse Progranulin PicoKine ELISA Kit standard curve 96 Tests Anmelden zum Anzeigen 4 bis 6 Tage
$369.00
Details
Ratte 0.065 ng/mL 0.15 ng/mL - 10 ng/mL 96 Tests Anmelden zum Anzeigen 13 bis 16 Tage
$800.00
Details
Meerschweinchen 1.0 pg/mL 50-1000 pg/mL   96 Tests Anmelden zum Anzeigen 15 bis 18 Tage
$707.14
Details
Kaninchen 1.0 pg/mL 50-1000 pg/mL   96 Tests Anmelden zum Anzeigen 15 bis 18 Tage
$707.14
Details
Schwein 0.938 ng/mL 1.563-100 ng/mL   96 Tests Anmelden zum Anzeigen 12 bis 14 Tage
$715.00
Details
Huhn 1.875 ng/mL 3.125-200 ng/mL   96 Tests Anmelden zum Anzeigen 12 bis 14 Tage
$715.00
Details
Affe 1.0 pg/mL 50-1000 pg/mL   96 Tests Anmelden zum Anzeigen 15 bis 18 Tage
$707.14
Details
Hund 1.0 pg/mL 50-1000 pg/mL   96 Tests Anmelden zum Anzeigen 15 bis 18 Tage
$707.14
Details

Am meisten referenzierte Granulin ELISA Kits

  1. Human Granulin ELISA Kit für Sandwich ELISA - ABIN578626 : Qu, Deng, Hu: Plasma progranulin concentrations are increased in patients with type 2 diabetes and obesity and correlated with insulin resistance. in Mediators of inflammation 2013 (PubMed)
    Show all 2 Pubmed References

Weitere ELISA Kits für Granulin Interaktionspartner

Zebrafish Granulin (GRN) Interaktionspartner

  1. The data od this study suggest that Pgrn-a plays a dual role during nervous system development by governing the rate at which progenitors progress through the cell cycle and attracting microglial progenitors into the embryonic brain and retina.

  2. Findings show that miR (zeige MYLIP ELISA Kits)-145 and GrnA expression patterns are inversely correlated during liver development and provide evidence that GrnA-dependent hepatic outgrowth is regulated by miR (zeige MYLIP ELISA Kits)-145 in zebrafish embryonic development.

  3. the Grna and Grnb single and double knock out zebrafish lack any obvious morphological, pathological and biochemical phenotypes

  4. GrnA positively modulates hepatic MET expression both in vivo and in vitro.

Human Granulin (GRN) Interaktionspartner

  1. CHI3L1 (zeige CHI3L1 ELISA Kits) may be a previously unrecognized biomarker for diagnosing Gaucher Diseases (GD) and for evaluating the therapeutic effects of new GD drug.

  2. The increased serum progranulin concentrations were closely related to measures of adiposity, metabolic parameters, inflammatory marker and insulin (zeige INS ELISA Kits) resistance indices, suggesting that progranulin may be an excellent biomarker for obesity in childhood.

  3. This work identifies PGRN as an activator of lysosomal cathepsin D (zeige CTSD ELISA Kits) activity, and suggests that decreased cathepsin D (zeige CTSD ELISA Kits) activity due to loss of PGRN contributes to both FTD (zeige FTL ELISA Kits) and NCL pathology in a dose-dependent manner.

  4. MiR (zeige MLXIP ELISA Kits)-29b-3p promotes chondrocyte apoptosis and facilitates the occurrence and development of osteoarthritis by targeting PGRN.

  5. Results provide evidence that progranulin destabilizes sortilin (zeige SORT1 ELISA Kits) via ubiquitination and lysosomal degradation to override the negative modulatory functions of sortilin (zeige SORT1 ELISA Kits) thereby assuring the sustainable pro-tumorigenic actions of progranulin in castration-resistant prostate cancer.

  6. PGRN is a regulator of tumorigenesis because it stimulates cell proliferation, migration, invasion, angiogenesis, malignant transformation, resistance to anticancer drugs, and immune evasion. [review]

  7. PGRN regulated its own expression in a positive feedback loop via the AKT (zeige AKT1 ELISA Kits) and ERK (zeige EPHB2 ELISA Kits) signaling pathways.

  8. PGRN is involved in lysosomal homeostasis and lipid metabolism.

  9. High serum GP88 concentrations are associated with poor prognosis in patients with DLBCL

  10. This study showed that endogenous levels of multiple GRNs are haploinsufficient in FTD (zeige FTL ELISA Kits)-GRN patient fibroblasts and frontal cortex, mirroring full-length PGRN.

Mouse (Murine) Granulin (GRN) Interaktionspartner

  1. CHI3L1 (zeige CHI3L1 ELISA Kits) may be a previously unrecognized biomarker for diagnosing Gaucher Diseases (GD) and for evaluating the therapeutic effects of new GD drug.

  2. this study shows that C5a/C5aR pathway accelerates renal ischemia-reperfusion injury by downregulating PGRN expression

  3. PGRN reduction from knock-in R504X mutation disinhibits Gas6 (zeige GAS6 ELISA Kits) binding to Tyro3 (zeige TYRO3 ELISA Kits), resulting in activation of PKCalpha (zeige PKCa ELISA Kits) via PLCgamma, inducing tau phosphorylation at Ser203, mislocalization of tau to dendritic spines, and spine loss

  4. PGRN haploinsufficiency may decrease accumulation of Abeta (zeige APP ELISA Kits).

  5. that mutations resulting in progranulin is processed in the lysosome through the actions of cathepsins

  6. Results from conditional progranulin-knockout mice that lack progranulin in nestin (zeige NES ELISA Kits)-expressing cells (Nes (zeige NES ELISA Kits)-cKO mice), which include most neurons as well as astrocytes, suggest that increased lipofuscinosis and gliosis in Grn-null animals are not caused by intrinsic progranulin deficiency in neurons, and that microglia-derived progranulin may be sufficient to maintain neuronal health and homeostasis in the brain.

  7. PGRN deficiency exacerbates neuroinflammatory responses related to activated microglia in aged animals, while PGRN may not counteract the decline of hippocampal neurogenesis with age.

  8. PGRN is involved in lysosomal homeostasis and lipid metabolism.

  9. findings suggest that PGRN deficiency leads to excessive NF-kappaB (zeige NFKB1 ELISA Kits) activation in microglia and elevated TNFalpha (zeige TNF ELISA Kits) signaling, which in turn lead to hyperexcitability of medium spiny neurons and obsessive-compulsive behavior-like behavior.

  10. PGRN plays a protecting role in hippocampal neurogenesis.

Guinea Pig Granulin (GRN) Interaktionspartner

  1. ADAM15 (zeige ADAM15 ELISA Kits) and acrogranin are present on and associated with the surface of guinea pig spermatozoa; besides both proteins may play a role during sperm-egg binding.

Granulin (GRN) Antigen-Profil

Beschreibung des Gens

Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis.

Genbezeichner und Symbole assoziert mit Granulin (GRN) ELISA Kits

  • granulin precursor (GRN) Antikörper
  • granulin a (grna) Antikörper
  • Granulins (grn) Antikörper
  • granulin L homeolog (grn.L) Antikörper
  • granulin (granulin) Antikörper
  • granulin (ORF1 granulin) Antikörper
  • granulin precursor (Grn) Antikörper
  • granulin (Grn) Antikörper
  • acrogranin Antikörper
  • CLN11 Antikörper
  • DKFZp459H066 Antikörper
  • epithelin Antikörper
  • GEP Antikörper
  • GP88 Antikörper
  • grn Antikörper
  • MGC53354 Antikörper
  • PCDGF Antikörper
  • PEPI Antikörper
  • PGRN Antikörper
  • wu:fb11g12 Antikörper
  • wu:fj18f05 Antikörper

Bezeichner auf Proteinebene für Granulin (GRN) ELISA Kits

granulin , granulin-a , zfPGRN-A , Granulins , PC cell-derived growth factor , acrogranin , granulin-epithelin , granulins , proepithelin , progranulin , PCDGF , PEPI , acrogranulin

GENE ID SPEZIES
454728 Pan troglodytes
100051035 Equus caballus
791524 Danio rerio
100195018 Salmo salar
380370 Xenopus laevis
1463344 Adoxophyes orana granulovirus
2776804 Agrotis segetum granulovirus
100173689 Pongo abelii
2896 Homo sapiens
29143 Rattus norvegicus
14824 Mus musculus
480501 Canis lupus familiaris
733645 Sus scrofa
767942 Bos taurus
100135533 Cavia porcellus
100349528 Oryctolagus cuniculus
101115470 Ovis aries
Ausgewählte Anbieter für Granulin (GRN) ELISA Kits
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