anti-Granulin (GRN) Antikörper

Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. Zusätzlich bieten wir Ihnen Granulin Kits (119) und Granulin Proteine (43) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
GRN 2896 P28799
GRN 29143 P23785
GRN 14824  
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Top anti-Granulin Antikörper auf antikoerper-online.de

Showing 10 out of 164 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert IHC, WB 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Human Kaninchen Unkonjugiert ICC, IF, IHC, IHC (p), WB Western Blot: Granulin Antibody [NBP1-32076] - Rat tissue extract (50 ug) was separated by 7.5% SDS-PAGE, and the membrane was blotted with Granulins antibody diluted at 1:1000. Western Blot: Granulin Antibody [NBP1-32076] - Sample (30 ug of whole cell lysate) A: HepG2 7. 5% SDS PAGE; antibody diluted at 1:1000. 0.1 mL Anmelden zum Anzeigen 7 bis 9 Tage
$514.63
Details
Human Ziege Unkonjugiert ELISA, WB EB08934 (1µg/ml) staining of HeLa lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Anmelden zum Anzeigen 6 bis 7 Tage
$358.02
Details
Human Kaninchen Unkonjugiert ICC, IF, IHC (p), WB WB Image Rat tissue extract (50 μg) was separated by 7.5% SDS-PAGE, and the membrane was blotted with Granulins antibody , diluted at 1:1000. WB Image Mouse tissue extract (50 μg) was separated by 7.5% SDS-PAGE, and the membrane was blotted with Granulins antibody , diluted at 1:1000. 100 μL Anmelden zum Anzeigen 1 bis 2 Tage
$358.60
Details
Human Kaninchen Unkonjugiert ICC, IF, IHC, IHC (p) Immunocytochemistry/Immunofluorescence: Granulin Antibody [NBP1-87325] Staining of human cell line U-251 MG shows positivity in vesicles. Immunohistochemistry-Paraffin: Granulin Antibody [NBP1-87325] - Staining of human duodenum shows strong cytoplasmic positivity in glandular cells. 0.1 mL Anmelden zum Anzeigen 10 bis 13 Tage
$491.63
Details
Human Kaninchen Unkonjugiert ICC, IF, IHC, IHC (p), WB Western Blot: Granulin Antibody [NBP1-87324] - Lane 1: NIH-3T3 cell lysate (Mouse embryonic fibroblast cells).Lane 2: NBT-II cell lysate (Rat Wistar bladder tumour cells) Immunocytochemistry/Immunofluorescence: Granulin Antibody [NBP1-87324] - Staining of human cell line A-431 shows positivity in vesicles. 0.1 mL Anmelden zum Anzeigen 10 bis 13 Tage
$491.63
Details
Maus Kaninchen Unkonjugiert ICC, IHC, WB Western Blot; Sample: Mouse Kidney lysate; Primary Ab: 2µg/ml Rabbit Anti-Mouse GRN Antibody Second Ab: 0.2µg/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody (Catalog: SAA544Rb19) 100 μg Anmelden zum Anzeigen 13 bis 16 Tage
$360.00
Details
Human Kaninchen Unkonjugiert IF (p), IHC (p), WB Formalin-fixed and paraffin embedded human esophageal carcinoma labeled with Anti PGRN/Granulin Polyclonal Antibody,Unconjugated (ABIN728668) at 1:200 followed by conjugation to the secondary antibody and DAB staining. Formalin-fixed and paraffin embedded human esophageal carcinoma labeled with Anti PGRN Granulin Polyclonal Antibody, unconjugated (ABIN728668) at 1:200 followed by incubation with conjugated secondary antibody and DAB staining. 100 μL Anmelden zum Anzeigen 3 bis 7 Tage
$318.45
Details
Human Maus Unkonjugiert ELISA, ELISA (Detection), IF, IF/ICC 100 μg Anmelden zum Anzeigen 20 bis 21 Tage
$218.90
Details
Hamster Ziege Unkonjugiert ELISA, WB 100 μg Anmelden zum Anzeigen 7 bis 9 Tage
$610.50
Details

GRN Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
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Am meisten referenzierte anti-Granulin Antikörper

  1. Human Polyclonal Granulin Primary Antibody für WB - ABIN1881391 : Bhandari, Bateman: Structure and chromosomal location of the human granulin gene. in Biochemical and biophysical research communications 1992 (PubMed)
    Show all 3 Pubmed References

  2. Human Monoclonal Granulin Primary Antibody für IP, IHC - ABIN1169394 : Ho, Ip, Cheung, Lee, Chan, Wong, Fan: Granulin-epithelin precursor as a therapeutic target for hepatocellular carcinoma. in Hepatology (Baltimore, Md.) 2008 (PubMed)
    Show all 2 Pubmed References

  3. Human Monoclonal Granulin Primary Antibody für ELISA, WB - ABIN966227 : Lu, Serrero: Stimulation of PC cell-derived growth factor (epithelin/granulin precursor) expression by estradiol in human breast cancer cells. in Biochemical and biophysical research communications 1999 (PubMed)
    Show all 2 Pubmed References

  4. Human Polyclonal Granulin Primary Antibody für IF (p), IHC (p) - ABIN728668 : Thurner, Fadle, Regitz, Kemele, Klemm, Zaks, Stöger, Bette, Carbon, Zimmer, Assmann, Murawski, Kubuschok, Held, Preuss, Pfreundschuh: The molecular basis for development of proinflammatory autoantibodies to progranulin. in Journal of autoimmunity 2015 (PubMed)

  5. Human Polyclonal Granulin Primary Antibody für ELISA, WB - ABIN439720 : Ghetti, Spina, Murrell, Huey, Pietrini, Sweeney, Wassermann, Keohane, Farlow, Grafman: In vivo and postmortem clinicoanatomical correlations in frontotemporal dementia and parkinsonism linked to chromosome 17. in Neuro-degenerative diseases 2008 (PubMed)

  6. Human Polyclonal Granulin Primary Antibody für ELISA, WB - ABIN561132 : Bandey, Chiou, Huang, Tsai, Tu: Progranulin promotes Temozolomide resistance of glioblastoma by orchestrating DNA repair and tumor stemness. in Oncogene 2015 (PubMed)

  7. Human Polyclonal Granulin Primary Antibody für ICC, IF - ABIN4315998 : Elkabets, Gifford, Scheel, Nilsson, Reinhardt, Bray, Carpenter, Jirström, Magnusson, Ebert, Pontén, Weinberg, McAllister: Human tumors instigate granulin-expressing hematopoietic cells that promote malignancy by activating stromal fibroblasts in mice. in The Journal of clinical investigation 2011 (PubMed)

  8. Human Polyclonal Granulin Primary Antibody für ICC, IF - ABIN4315995 : Kahle, Gulbahce, Shaw, Lim, Hill, Barabási, Zoghbi: Comparison of an expanded ataxia interactome with patient medical records reveals a relationship between macular degeneration and ataxia. in Human molecular genetics 2011 (PubMed)

Weitere Antikörper gegen Granulin Interaktionspartner

Zebrafish Granulin (GRN) Interaktionspartner

  1. Findings show that miR (zeige MYLIP Antikörper)-145 and GrnA expression patterns are inversely correlated during liver development and provide evidence that GrnA-dependent hepatic outgrowth is regulated by miR (zeige MYLIP Antikörper)-145 in zebrafish embryonic development.

  2. the Grna and Grnb single and double knock out zebrafish lack any obvious morphological, pathological and biochemical phenotypes

  3. GrnA positively modulates hepatic MET expression both in vivo and in vitro.

Human Granulin (GRN) Interaktionspartner

  1. HSPA5 (GRP78 (zeige HSPA5 Antikörper)) and GEP (zeige GNA12 Antikörper) were identified to interact. Clinical analysis showed that expression of GRP78 (zeige HSPA5 Antikörper) was up-regulated in hepatocellular carcinoma tumor and correlated with GEP (zeige GNA12 Antikörper) expression.

  2. the expression of PGRN was significantly upregulated in Osteonecrosis of the Femoral Head patients' articular cartilage, and recombinant PGRN could promote expression of aggrecan and collagen II and the activation of ERK1/2.

  3. White matter hyperintensities are seen only in GRN mutation carriers in fronto-temporal dementia.

  4. The study provides solid evidence that there is the interaction between GRN A and ENO1 and the interaction is responsible for the effects of GRN A on glucose uptake as well as cancer cell migration and invasion.

  5. This study ascertained that PGRN expression in airway epithelial cells inhibits CS-induced apoptosis, presumably through regulation of the ER stress response and MAPK (zeige MAPK1 Antikörper) activation.

  6. mTOR (zeige FRAP1 Antikörper) signaling contributes to PGRN-stimulated carcinogenesis of cervical cancer

  7. This study describe a novel GRN, p.(Tyr229*) mutation, resulting in haploinsufficiency of GRN and a severe neuropathologic FTLD phenotype.

  8. This meta-analysis supported the T allele of rs5848 within progranulin, as a risk factor for Alzheimer's Disease.

  9. Our case report further corroborates the notion that, in addition to FTD (zeige FTL Antikörper), progranulin may be involved in the neurobiology of bipolar disorder type 1, and suggests to screen patients with late-onset bipolar disorder for GRN mutations.

  10. GRN SNPs likely influence disease course and relapse recovery in multiple sclerosis.

Mouse (Murine) Granulin (GRN) Interaktionspartner

  1. PGRN plays a protecting role in hippocampal neurogenesis.

  2. This study ascertained that PGRN expression in airway epithelial cells inhibits CS-induced apoptosis, presumably through regulation of the ER stress response and MAPK (zeige MAPK1 Antikörper) activation.

  3. This study demonstrated that Progranulin overexpression in sensory neurons attenuates neuropathic pain in mice.

  4. The results of this study show that endogenous and recombinant PGRN limit axonal injury and astrogliosis and suggest therapeutic potential of PGRN in traumatic brain injury.

  5. progranulin expression is critical for tumor growth in vivo, in both xenograft and orthotopic tumor models

  6. Study demonstrate that PGRN interacts with the lysosomal protease CTSD (zeige CTSD Antikörper) and maintains its proper activity in vivo. Therefore, by regulating CTSD (zeige CTSD Antikörper) activity, PGRN may modulate protein homeostasis. This could potentially explain the TDP-43 (zeige TARDBP Antikörper) aggregation observed in frontotemporal lobar degeneration with GRN mutations.

  7. Findings suggest that elevated PGRN is linked to cognitive deficits of fragile X (zeige FMR1 Antikörper) syndrome.

  8. highlight an important role for neuron-derived progranulin in maintaining normal social function.

  9. overexpression of PGRN was also found to increase activity of neprilysin (zeige MME Antikörper), a key amyloid beta degrading enzyme. PGRN regulation of neprilysin (zeige MME Antikörper) activity could play a major role in the observed alterations in plaque burden

  10. PGRN decrease, resulting from pathogenic mutations, might compromise the trophism of cortical neurons by affecting GluN2B (zeige GRIN2B Antikörper)-contaning NMDA receptors

Guinea Pig Granulin (GRN) Interaktionspartner

  1. ADAM15 (zeige ADAM15 Antikörper) and acrogranin are present on and associated with the surface of guinea pig spermatozoa; besides both proteins may play a role during sperm-egg binding.

Granulin (GRN) Antigen-Profil

Protein Überblick

Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis.

Genbezeichner und Symbole assoziert mit anti-Granulin (GRN) Antikörper

  • granulin precursor (GRN) Antikörper
  • granulin a (grna) Antikörper
  • Granulins (grn) Antikörper
  • granulin L homeolog (grn.L) Antikörper
  • granulin (granulin) Antikörper
  • granulin (ORF1 granulin) Antikörper
  • granulin precursor (Grn) Antikörper
  • granulin (Grn) Antikörper
  • acrogranin Antikörper
  • CLN11 Antikörper
  • DKFZp459H066 Antikörper
  • epithelin Antikörper
  • GEP Antikörper
  • GP88 Antikörper
  • grn Antikörper
  • MGC53354 Antikörper
  • PCDGF Antikörper
  • PEPI Antikörper
  • PGRN Antikörper
  • wu:fb11g12 Antikörper
  • wu:fj18f05 Antikörper

Bezeichner auf Proteinebene für anti-Granulin (GRN) Antikörper

granulin , granulin-a , zfPGRN-A , Granulins , PC cell-derived growth factor , acrogranin , granulin-epithelin , granulins , proepithelin , progranulin , PCDGF , PEPI , acrogranulin

GENE ID SPEZIES
454728 Pan troglodytes
100051035 Equus caballus
791524 Danio rerio
100195018 Salmo salar
380370 Xenopus laevis
1463344 Adoxophyes orana granulovirus
2776804 Agrotis segetum granulovirus
100173689 Pongo abelii
2896 Homo sapiens
29143 Rattus norvegicus
14824 Mus musculus
480501 Canis lupus familiaris
733645 Sus scrofa
767942 Bos taurus
100135533 Cavia porcellus
100349528 Oryctolagus cuniculus
101115470 Ovis aries
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