Glycoprotein VI (Platelet) Proteine (GP6)

GP6 encodes a platelet membrane glycoprotein of the immunoglobulin superfamily. Zusätzlich bieten wir Ihnen GP6 Antikörper (75) und GP6 Kits (40) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
GP6 51206 Q9HCN6
GP6 243816 P0C191
Ratte GP6 GP6 684555  
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Showing 3 out of 6 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Maus rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Anmelden zum Anzeigen 50 bis 55 Tage
$5,262.31
Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$6,749.58
Details
Escherichia coli (E. coli) Human His tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$698.00
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GP6 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human ,
,
Mouse (Murine)
,

Weitere Proteine zu Glycoprotein VI (Platelet) (GP6) Interaktionspartnern

Human Glycoprotein VI (Platelet) (GP6) Interaktionspartner

  1. there is an altered activation state of GPVI signaling in ST-elevation myocardial infarction patients; GPVI is critical for the formation of arterial thrombosis in vivo

  2. haplotype PEAN associated with SPS and manifested by fetal loss and suggest that the mechanism involved in the action of GPVI has significant effect on GPVI-mediated signal transduction through Syk-phosphorylation.

  3. This suggests whereas platelet receptor shedding is mainly modulated by calcium-dependent signals, either platelet-surface interactions with the container walls during storage or induced shear stress under long-term agitation, might be also involved in the excessive shedding of GPVI during the storage of PRP-platelet concentrates.

  4. There was no evidence to suggest that polymorphisms of GP VI T13254C and GP Ibalpha VNTR were associated with CAD.

  5. Platelet adhesion to collagen induces GPVI dimer clustering. GPVI clustering increases both avidity for collagen and the proximity of GPVI-associated signaling molecules, which may be crucial for the initiation and persistence of signaling

  6. Loss of the platelet surface receptors GPIbalpha and GPVI in heart failure, CF-VAD and ECMO patients may contribute to ablated platelet adhesion/activation, and limit thrombus formation under high/pathologic shear conditions

  7. SGPVI was significantly lower in patients treated with NOACs.

  8. Novel antithrombotic peptides derived from trowaglerix that acts through GPVI antagonism with greater safety-no severe bleeding.

  9. rs1613662 polymorphism has an important role in the development of venous thromboembolism in the white race

  10. plasma sGPVI levels are related to platelet activation in Living Donor Liver Transplantation. Although the plasma levels of sGPVI in the survivors increased after the operation, those in the nonsurvivors were high only on day 3.

  11. results support the idea that genetic variability of GP6 regulatory regions can be associated with platelet hyperaggregability - a possible cause of miscarriage

  12. These results demonstrate that GP6 is a receptor for fibrin and provide evidence that this interaction contributes to thrombus growth and stability.

  13. data suggest a novel role for FAK in GPVI-dependent ROS formation and platelet activation and elucidate a proximal signaling role for FAK within the GPVI pathway.

  14. As sCD147 strongly correlates with platelet-specific sGPVI, a common platelet source and/or mechanism of release may contribute to sCD147 levels in vivo.

  15. This study identifies GPVI as a platelet receptor for polymerized fibrin with 2 major functions: (1) amplification of thrombin generation and (2) recruitment of circulating platelets to clots.

  16. measuring the level of sGPVI may be useful for assessing the activation of platelets in postoperative patients treated with anti-Xa agents and also for predicting the incidence of VTE in this population.

  17. Glaucocalyxin A inhibits platelet activation and thrombus formation preferentially via GPVI signaling pathway.

  18. The plasma levels of sGPVI were the highest in patients with TMA without markedly reduced ADAMTS13 and those were significantly reduced after plasma exchange.

  19. Results suggest that variants of GP6 SNPs, namely, rs1671153, rs1654410, rs1654419, and rs1613662, may be associated with risk of recurrent miscarriage.

  20. Lower platelet GPIV levels are associated with no-reflow phenomenon in patients with acute myocardial infarction.

Mouse (Murine) Glycoprotein VI (Platelet) (GP6) Interaktionspartner

  1. Platelet-specific deletion of GPVI does not lead to enhanced systemic inflammation and accelerated organ injury in two mouse models of sepsis

  2. Tspan9 regulates platelet collagen receptor GPVI lateral diffusion and activation.

  3. In conclusion, the present study unraveled ceramidase as a crucial player in sphingosine-induced platelet activation following GPVI-dependent signaling.

  4. These results reveal a novel and unexpected function of hepatic Fc-gamma-RIIB in the targeted downregulation of GPVI in vivo.

  5. collagen-I-mediated inhibition of proplatelet formation is specifically controlled by GPVI.

  6. platelet GP6 and thromboxane A2 receptor have a role in promoting inflammatory macrophage phenotype in skin inflammation

  7. Novel antithrombotic peptides derived from trowaglerix that acts through GPVI antagonism with greater safety-no severe bleeding.

  8. TULA-2 Protein Phosphatase Suppresses Activation of Syk through the GPVI Platelet Receptor for Collagen by Dephosphorylating Tyr(P)346, a Regulatory Site of Syk.

  9. Inhibition of platelet activation by an anti-GPVI antibody significantly reduces infarct size.

  10. These results demonstrate that GPVI is a receptor for fibrin and provide evidence that this interaction contributes to thrombus growth and stability.

  11. data demonstrate that genetic deletion of GPVI receptor, FcRgamma chain, or the alpha2beta1 integrin changes the thrombotic potentials of these platelets to collagen dependent on the stimulus mechanism.

  12. data suggest a novel role for FAK in GPVI-dependent ROS formation and platelet activation and elucidate a proximal signaling role for FAK within the GPVI pathway.

  13. our results show that GPVI plays a dual role in inflammation by enhancing neutrophil-damaging activities while supporting the activation and hemostatic adhesion of single platelets to neutrophil-induced vascular breaches.

  14. This study identifies GPVI as a platelet receptor for polymerized fibrin with 2 major functions: (1) amplification of thrombin generation and (2) recruitment of circulating platelets to clots.

  15. Functional studies of platelets from Ceacam2(-/-)-deficient mice (Cc2(-/-)) revealed that CEACAM2 serves to negatively regulate collagen glycoprotein VI (platelet) (GPVI)-FcRgamma-chain and the C-type lectinlike receptor 2 (CLEC-2) signaling

  16. Glaucocalyxin A inhibits platelet activation and thrombus formation preferentially via GPVI signaling pathway.

  17. a delayed and markedly reduced thrombogenic response was still evident in VWF(-/-), GPVI, and alpha2beta1 blocked animals, suggesting that alternative primary hemostatic mechanisms can partially rescue the bleeding phenotype associated with these defects.

  18. RhoG is expressed and activated in platelets, plays an important role in GPVI-Fc receptor gamma-chain complex-mediated platelet activation, and is critical for thrombus formation in vivo.

  19. demonstrate that isolated targeting of either GPVI or CLEC-2 in vivo does not affect expression or function of the respective other receptor

  20. Data show an inhibitory function of CLP-36 in GPVI immunoreceptor tyrosine-based activation motif signaling and as a key regulator of arterial thrombosis.

GP6 Protein Überblick

Protein Überblick

This gene encodes a platelet membrane glycoprotein of the immunoglobulin superfamily. The encoded protein is a receptor for collagen and plays a critical role in collagen-induced platelet aggregation and thrombus formation. The encoded protein forms a complex with the Fc receptor gamma-chain that initiates the platelet activation signaling cascade upon collagen binding. Mutations in this gene are a cause of platelet-type bleeding disorder-11 (BDPLT11). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Genbezeichner und Symbole assoziert mit GP6

  • glycoprotein VI platelet (GP6)
  • glycoprotein 6 (platelet) (Gp6)
  • glycoprotein VI (Gp6)
  • glycoprotein VI platelet (Gp6)
  • platelet glycoprotein VI (LOC103346235)
  • 9830166G18Rik Protein
  • BDPLT11 Protein
  • Gm469 Protein
  • GP6 Protein
  • GPIV Protein
  • Gpvi Protein

Bezeichner auf Proteinebene für GP6

glycoprotein 6 , platelet collagen receptor , platelet glycoprotein VI , glycoprotein VI (platelet) , glycoprotein 5 , glycoprotein 6 (platelet) , glycoprotein VI

GENE ID SPEZIES
51206 Homo sapiens
456429 Pan troglodytes
484303 Canis lupus familiaris
243816 Mus musculus
101123066 Ovis aries
684555 Rattus norvegicus
106026629 Cavia porcellus
103346235 Oryctolagus cuniculus
100517829 Sus scrofa
102188249 Capra hircus
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