anti-Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) Antikörper

Human Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) Interaktionspartner

1. This suggests that RX624 might be useful as a drug against polyglutamine pathologies, and that is could be administered exogenously without affecting target cell physiology. This protective effect was validated by the similar effect of an anti-GAPDH specific antibody.

2. GAPDH can interact with proteins participating in DNA repair, such as APE1 (zeige APEX1 Antikörper), PARP1 (zeige PARP1 Antikörper), HMGB1 (zeige HMGB1 Antikörper), and HMGB2 (zeige HMGB2 Antikörper). In this review, the functions of GAPDH associated with DNA repair are discussed in detail.

3. Nitric oxide-induced GAPDH aggregation specifically induces mitochondrial dysfunction via permeability transition pore opening, leading to cell death.

4. GAPDH may act as a chaperone in heme transfer to downstream areas

5. NAD(+) inhibited both GAPDH aggregation and co-aggregation with GOSPEL (zeige RILPL1 Antikörper), a hitherto undescribed effect of the coenzyme against the consequences of oxidative stress.

6. Monoclonal Antibodies DSHB-hGAPDH-2G7 and DSHB-hGAPDH-4B7 Against Human Glyceraldehyde-3-Phosphate Dehydrogenase.

7. the present study suggests that GAPDH plays an important role in cancer metastasis by affecting EMT (zeige ITK Antikörper) through regulation of Sp1 (zeige PSG1 Antikörper)-mediated SNAIL (zeige SNAI1 Antikörper) expression.

8. Knockdown of LAMP2A, a CMA-related protein, and TSG101 (zeige TSG101 Antikörper), an mA-related protein, significantly but only partially decreased the punctate accumulation of GAPDH-HT in AD293 cells and primary cultured rat cortical neurons.

9. In conclusion, the data show that two GAPDH binders could be therapeutically relevant in the treatment of injuries stemming from hard oxidative stress.

10. transient silencing of GAPDH reduces intracellular ROS (zeige ROS1 Antikörper) and facilitates increased autophagy, thereby reducing acute hypoxia and reoxygenation injury as well as the resulting apoptosis and necrosis.

Cow (Bovine) Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) Interaktionspartner

1. GAPDH with CytOx could be the point of interest as it has already been shown that GAPDH protein damage results in a marked decrease in cellular ATP levels

2. present in, and accounts for, glycolysis and glutamate (zeige GRIN2A Antikörper) accumulation into synaptic vesicles

3. GAPDH phosphorylates the long intracellular loop of GABA(A) receptor alpha1 subunit at Ser (zeige SIGLEC1 Antikörper)-416 & Thr (zeige TRH Antikörper)-337. The neuronal membrane-attached GAPDH is a dual-purpose enzyme, a glycolytic dehydrogenase, & a receptor-associated kinase.

4. Results show that expression of GAPD increased during the late fattening stage of of hanwoo steers and it is involved in metabolic pathways such as glycolysis and the TCA cycle.

Zebrafish Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) Interaktionspartner

1. amino acid sequences were used to establish the 3D structures of the active site of glyceraldehyde-3-phosphate dehydrogenase and the phylogenetic relationships of the sardine and octopus enzymes

2. The expression level of GAPDH was upregulated to a greater extent than those for myogenin (zeige MYOG Antikörper) and myostatin 1 under restricted feeding.

Mouse (Murine) Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) Interaktionspartner

1. the GluA2 (zeige GRIA2 Antikörper) subunit via its interaction with GAPDH, play a critical role in cortical neurodevelopment.

2. These findings show that post-translational modification of GAPDH lysine residues regulates hepatic and systemic metabolism, revealing an unappreciated role for hepatic GAPDH in substrate selection and utilization.

3. These results suggest that GAPDH is an ancient, evolutionarily conserved receptor that plays a key role in the Plg (zeige PLG Antikörper)-dependent regulation of macrophage recruitment in the inflammatory response to microbial aggression, thus pitting prokaryotic GAPDH against mammalian GAPDH, with both involved in a conserved role of Plg (zeige PLG Antikörper) activation on the surface of their respective cells, to conflicting ends.

4. GAPDH-mediated expression regulation of sodium channel genes was associated with epilepsy and the anticonvulsant action of the ketogenic diet.

5. Exosomal GAPDH from Proximal Tubule Cells Regulate ENaC (zeige SCNN1A Antikörper) Activity

6. Data indicate that lactoferrin (zeige LTF Antikörper) uptake across duodenum by glyceraldehyde-3-phosphate dehydrogenase (GAPDH).

7. astrocytic production of D-serine is modulated by glycolytic activity via interactions between GAPDH and SRR (zeige SRR Antikörper).

8. Selective inhibition of the glycolytic pathway through GAPDH in chronic lymphocytic leukemia cells with nanoliposomal C6-ceramide could be an effective therapy for leukemia by targeting the Warburg effect.

9. glyceraldehyde-3-phosphate dehydrogenase plays a critical role in determining the superior functions of female bone marrow-derived mesenchymal stem cells in cell therapy against pulmonary arterial hypertension.

10. Data indicate that the HNO-nonsteroidal anti-inflammatory drugs (NSAIDs) prodrug inhibited cylcooxgenase-2 and glyceraldehyde 3-phosphate dehydrogenase activity and triggered significant sarcomere shortening on murine ventricular myocytes.

Xenopus laevis Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) Interaktionspartner

1. The effect of metal ions on the activity of glyceraldehyde-3-phosphate dehydrogenase.

Pig (Porcine) Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) Interaktionspartner

1. The structure-bound sperm-specific enzymes, GAPDH-S and pyruvate kinase(PK-S), appeared only late in spermatogenesis simultaneously with the development of the structures to which they are bound.

Rabbit Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) Interaktionspartner

1. has been shown that the stage of aggregate growth follows the first-order kinetics and the experimentally measured rate constant of the first order corresponds to heat-induced structural reorganization of UV-irradiated GAPDH containing concealed damage.

2. Low micromolar levels of 3,4-dihydroxyphenylacetaldehyde caused extensive GAPDH aggregation and irreversibly inhibited enzyme activity.

3. The level of GAPDH-AP DNA adduct formation depends on oxidation of the protein SH-groups; disulfide bond reduction in GAPDH leads to the loss of its ability to form the adducts with AP DNA

4. The strength, selectivity, reversibility, and redox sensitivity of heme binding to GAPDH are consistent with it performing heme sensing or heme chaperone-like functions in cells.

5. Purified UCH-L1 (zeige UCHL1 Antikörper) and GAPDH were nitrated in vitro with peroxynitrite and the presence of nitrated proteins was confirmed by anti-3-nitrotyrosine Western blots.Subsequent validation with synthetic peptides was conducted for selected nitropeptides.

6. dissociation of alpha-crystallin and GAPDH

7. results strongly suggest that Tyr311 and Tyr317 nitration prohibits NAD(+) binding, leading to the loss of catalytic activity of GAPDH.

8. In the presence of alpha-crystallin or GroEL (zeige GroEL Antikörper) the kinetic of GAPDH aggregation is changed from the diffusion-limited cluster-cluster aggregation to the reaction-limited cluster-cluster aggregation.

9. The interactions described herein between the beta subunit (zeige POLG Antikörper) of PhK and GAPDH provide a possible mechanism for the direct linkage of glycogenolysis and glycolysis in skeletal muscle.

10. FKBP36 (zeige FKBP6 Antikörper) diminishes GAPDH activity by direct interaction and down-regulation of GAPDH