anti-Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) Antikörper

Human Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) Interaktionspartner

1. This suggests that RX624 might be useful as a drug against polyglutamine pathologies, and that is could be administered exogenously without affecting target cell physiology. This protective effect was validated by the similar effect of an anti-GAPDH specific antibody.

2. GAPDH can interact with proteins participating in DNA repair, such as APE1, PARP1, HMGB1, and HMGB2. In this review, the functions of GAPDH associated with DNA repair are discussed in detail.

3. Nitric oxide-induced GAPDH aggregation specifically induces mitochondrial dysfunction via permeability transition pore opening, leading to cell death.

4. GAPDH may act as a chaperone in heme transfer to downstream areas

5. NAD(+) inhibited both GAPDH aggregation and co-aggregation with GOSPEL, a hitherto undescribed effect of the coenzyme against the consequences of oxidative stress.

6. Monoclonal Antibodies DSHB-hGAPDH-2G7 and DSHB-hGAPDH-4B7 Against Human Glyceraldehyde-3-Phosphate Dehydrogenase.

7. the present study suggests that GAPDH plays an important role in cancer metastasis by affecting EMT through regulation of Sp1-mediated SNAIL expression.

8. Knockdown of LAMP2A, a CMA-related protein, and TSG101, an mA-related protein, significantly but only partially decreased the punctate accumulation of GAPDH-HT in AD293 cells and primary cultured rat cortical neurons.

9. In conclusion, the data show that two GAPDH binders could be therapeutically relevant in the treatment of injuries stemming from hard oxidative stress.

10. transient silencing of GAPDH reduces intracellular ROS and facilitates increased autophagy, thereby reducing acute hypoxia and reoxygenation injury as well as the resulting apoptosis and necrosis.

11. This review will summarize our current understanding of GAPDH-mediated regulation of RNA function

12. analysis of PSCA level in the peripheral blood of PC patients who underwent radical prostatectomy shows it is related to a GADPH reference level (PSCA/GAPDH ratio)

13. In 60 % of patients with type 2 diabetes, a reversible inhibition of GAPDH is observed.

14. The results of this study led us to conclude that in cancer cells constantly exposed to conditions of oxidative stress, the protective power of Hsp70 should be abolished by specific inhibitors of Hsp70 expression.

15. GAPDH and protoporphyrinogen oxidase were shown to have higher expression in faster growing cell lines and primary tumors. Pharmacologic inhibition of GAPDH or PPOX reduced the growth of colon cancer cells in vitro

16. The levels of GAPDH protein were significantly up-regulated in lung squamous cell carcinoma tissues and elevated GAPDH expression is associated with the proliferation and invasion of lung and esophageal squamous cell carcinomas.

17. Genetic variants in GAPDH confer susceptibility to sporadic Parkinson's disease in a Chinese Han population.

18. Data revealed that GAPDH is a phosphorylation substrate for AMPK and its interaction with Sirt1 in the nucleus. The phosphorylation and the nuclear translocation of GAPDH mediate rapid Sirt1 activation and autophagy initiation under glucose deprivation.

19. findings demonstrate that dissociation of the GAPDH/Siah1 pro-apoptotic complex can block high glucose-induced pericyte apoptosis, widely considered a hallmark feature of diabetic retinopathy

20. Extracellular GAPDH, or its N-terminal domain, inhibited gastric cancer cell growth. GAPDH bound to E-cadherin and downregulated the mTOR-p70S6 kinase pathway.

Cow (Bovine) Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) Interaktionspartner

1. GAPDH with CytOx could be the point of interest as it has already been shown that GAPDH protein damage results in a marked decrease in cellular ATP levels

2. present in, and accounts for, glycolysis and glutamate accumulation into synaptic vesicles

3. GAPDH phosphorylates the long intracellular loop of GABA(A) receptor alpha1 subunit at Ser-416 & Thr-337. The neuronal membrane-attached GAPDH is a dual-purpose enzyme, a glycolytic dehydrogenase, & a receptor-associated kinase.

4. Results show that expression of GAPD increased during the late fattening stage of of hanwoo steers and it is involved in metabolic pathways such as glycolysis and the TCA cycle.

Zebrafish Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) Interaktionspartner

1. amino acid sequences were used to establish the 3D structures of the active site of glyceraldehyde-3-phosphate dehydrogenase and the phylogenetic relationships of the sardine and octopus enzymes

2. The expression level of GAPDH was upregulated to a greater extent than those for myogenin and myostatin 1 under restricted feeding.

Mouse (Murine) Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) Interaktionspartner

1. expression and sub-cellular localization change through gestation in the placenta

2. the GluA2 subunit via its interaction with GAPDH, play a critical role in cortical neurodevelopment.

3. These findings show that post-translational modification of GAPDH lysine residues regulates hepatic and systemic metabolism, revealing an unappreciated role for hepatic GAPDH in substrate selection and utilization.

4. These results suggest that GAPDH is an ancient, evolutionarily conserved receptor that plays a key role in the Plg-dependent regulation of macrophage recruitment in the inflammatory response to microbial aggression, thus pitting prokaryotic GAPDH against mammalian GAPDH, with both involved in a conserved role of Plg activation on the surface of their respective cells, to conflicting ends.

5. GAPDH-mediated expression regulation of sodium channel genes was associated with epilepsy and the anticonvulsant action of the ketogenic diet.

6. Exosomal GAPDH from Proximal Tubule Cells Regulate ENaC Activity

7. Data indicate that lactoferrin uptake across duodenum by glyceraldehyde-3-phosphate dehydrogenase (GAPDH).

8. astrocytic production of D-serine is modulated by glycolytic activity via interactions between GAPDH and SRR.

9. Selective inhibition of the glycolytic pathway through GAPDH in chronic lymphocytic leukemia cells with nanoliposomal C6-ceramide could be an effective therapy for leukemia by targeting the Warburg effect.

10. glyceraldehyde-3-phosphate dehydrogenase plays a critical role in determining the superior functions of female bone marrow-derived mesenchymal stem cells in cell therapy against pulmonary arterial hypertension.

11. Data indicate that the HNO-nonsteroidal anti-inflammatory drugs (NSAIDs) prodrug inhibited cylcooxgenase-2 and glyceraldehyde 3-phosphate dehydrogenase activity and triggered significant sarcomere shortening on murine ventricular myocytes.

12. Gapdh is a moonlighting protein that functions as a glycolytic enzyme and a transferrin receptor.

13. Gapdh is a moonlighting protein that functions as a glycolytic enzyme and additionally is involved in regulating mRNA stability.

14. Gapdh is a moonlighting protein that functions as a glycolytic enzyme and a nuclear protein nitrosylase.

15. Overexpression of GAPDH significantly augmented Mst1 mediated apoptosis, whereas knockdown of GAPDH markedly attenuated Mst1 activation and cardiomyocyte apoptosis.

16. analysis of a GAPDH/PKCdelta signaling switch, which is activated during oxidative stress to regulate the balance between cell survival by mitophagy and cell death due to accumulation of damaged mitochondria

17. For gene expression analysis in the developing murine neocortex, Gapdh is recommended as a reference gene based on the authors' ranking.

18. investigated whether glyceraldehyde-3-phosphate dehydrogenase (GAPDH) binds to the AU-rich element (ARE) of COX-2 mRNA for its degradation. Knockdown of GAPDH significantly enhanced COX-2 expressions.

19. the triad of Ser(999)-phosphorylated EPRS, Ser(77)-phosphorylated L13a, and GAPDH forms a functional GAIT complex that inhibits translation of GAIT target mRNAs

20. The B23 physiologically bound to both SIAH1 and GAPDH, disrupting the SIAH1-GAPDH complex in the nucleus in response to nitrosative stress.

Xenopus laevis Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) Interaktionspartner

1. The effect of metal ions on the activity of glyceraldehyde-3-phosphate dehydrogenase.

Pig (Porcine) Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) Interaktionspartner

1. The structure-bound sperm-specific enzymes, GAPDH-S and pyruvate kinase(PK-S), appeared only late in spermatogenesis simultaneously with the development of the structures to which they are bound.

Rabbit Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) Interaktionspartner

1. has been shown that the stage of aggregate growth follows the first-order kinetics and the experimentally measured rate constant of the first order corresponds to heat-induced structural reorganization of UV-irradiated GAPDH containing concealed damage.

2. Low micromolar levels of 3,4-dihydroxyphenylacetaldehyde caused extensive GAPDH aggregation and irreversibly inhibited enzyme activity.

3. The level of GAPDH-AP DNA adduct formation depends on oxidation of the protein SH-groups; disulfide bond reduction in GAPDH leads to the loss of its ability to form the adducts with AP DNA

4. The strength, selectivity, reversibility, and redox sensitivity of heme binding to GAPDH are consistent with it performing heme sensing or heme chaperone-like functions in cells.

5. Purified UCH-L1 and GAPDH were nitrated in vitro with peroxynitrite and the presence of nitrated proteins was confirmed by anti-3-nitrotyrosine Western blots.Subsequent validation with synthetic peptides was conducted for selected nitropeptides.

6. dissociation of alpha-crystallin and GAPDH

7. results strongly suggest that Tyr311 and Tyr317 nitration prohibits NAD(+) binding, leading to the loss of catalytic activity of GAPDH.

8. In the presence of alpha-crystallin or GroEL the kinetic of GAPDH aggregation is changed from the diffusion-limited cluster-cluster aggregation to the reaction-limited cluster-cluster aggregation.

9. The interactions described herein between the beta subunit of PhK and GAPDH provide a possible mechanism for the direct linkage of glycogenolysis and glycolysis in skeletal muscle.

10. FKBP36 diminishes GAPDH activity by direct interaction and down-regulation of GAPDH