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The protein encoded by GRPP is actually a preproprotein that is cleaved into four distinct mature peptides.
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Everolimus down-regulates the systemic levels of gastrin (zeige GAST Antikörper) and glucagon (zeige GCG Antikörper) in patients with pancreatic neuroendocrine tumors.
Glucagon (zeige GCG Antikörper)-like peptide (GLP-2 (zeige GCG Antikörper)) stimulates cancer myofibroblast proliferation, migration and invasion; GLP-2 (zeige GCG Antikörper) acts indirectly on epithelial cells partly via increased Insulin (zeige INS Antikörper)-like growth factor (IGF) expression in myofibroblasts.
Describe model, in which the release of GIP (zeige GIP Antikörper)/GLP-1 (zeige GCG Antikörper) is stimulated by glucose in the proximal small intestine, and no differences in the secretion dynamics between healthy individuals and patients with T2D are identified after taking differences in glucose profiles into account.
the solvent exposure of the two Phe sites along the glucagon (zeige GCG Antikörper) sequence was determined, showing that 4F-Phe6 was fully solvent exposed and 4F-Phe22 was only partially exposed
Data suggest that dose/intensity-response relationships exist between exercise intensity and total plasma PYY levels, though the effects on total plasma GLP1 (zeige GCG Antikörper) levels and hunger perceptions seem unclear. (PYY = peptide YY ; GLP1 (zeige GCG Antikörper) = glucagon-like peptide 1 (zeige GCG Antikörper))
GLP-2 could be considered an hormone causing positive energy balance, which, however has the role to mitigate the metabolic dysfunctions associated with hyper-adiposity. [review]
Studies indicate that nutrient-induced glucagonlike peptide-1 (GLP-1 (zeige GCG Antikörper)) response was one of the best predictors of type 2 diabetes mellitus (T2DM) remission after Roux-en-Y-gastric-bypass (RYGB).
Insulin (zeige INS Antikörper) resistance in non-diabetic individuals is associated with raised fasting GLP-1 (zeige GCG Antikörper) levels but reduced GLP-1 (zeige GCG Antikörper) responses to meal stimulation.
we saw that GLP-1 (zeige GCG Antikörper) induces phosphorylation of the epidermal growth factor receptor (zeige EGFR Antikörper) and activation of Foxo1 (zeige FOXO1 Antikörper), resulting in cell growth with concomitant enzyme release. Our work uncovers GLP-1 (zeige GCG Antikörper)-induced signaling pathways in the exocrine pancreas and suggests that increases in amylase (zeige AMY Antikörper) and lipase (zeige LIPG Antikörper) levels in subjects treated with GLP-1 receptor (zeige GLP1R Antikörper) agonists reflect adaptive growth rather than early-stage pancreatitis.
Age-dependent human beta cell proliferation induced by glucagon-like peptide 1 and calcineurin signaling
Glucokinase (zeige GCK Antikörper) governs an alpha-cell metabolic pathway that suppresses secretion at or above normoglycemic levels; abnormal suppression of glucagon (zeige GCG Antikörper) secretion deregulates hepatic glucose metabolism and, over time, induces a pre-diabetic phenotype.
in colonic crypt cultures, the GLP-1 (zeige GCG Antikörper) secretion induced by such Gq + Gs GPR40 (zeige FFAR1 Antikörper) agonists is indeed inhibited by blockers of both Gq and Gs and is eliminated by combining these.
Enteric GLP-1 (zeige GCG Antikörper) activates NO production by enteric neurons that is impaired in type 2 diabetes. Gut (zeige GUSB Antikörper) microbiota dysbiosis induces enteric neuropathy. Gut (zeige GUSB Antikörper) microbiota dysbiosis is responsible for the GLP-1 (zeige GCG Antikörper) resistance.
of glucagon-like peptide-1 (zeige GCG Antikörper) in vagotomized mice may prevent VLDL overproduction and insulin (zeige INS Antikörper) resistance induced by high-fat diet.
beta-cell function, plasma active GLP-1 (zeige GCG Antikörper) levels, the GLP-1R (zeige GLP1R Antikörper) pathway in beta cells and L cell differentiation, were investigated.
CCK (zeige CCK Antikörper)/GLP-1 (zeige GCG Antikörper) play contributory roles in anorexia induction by trichothecenes T-2 toxin, HT-2 toxin, diacetoxyscirpenol and neosolaniol.
The role of syntaxin 1A (zeige STX1A Antikörper) in GLP1 (zeige GCG Antikörper) release from intestinal cells as a response to external stimuli is reported.
GCG (zeige GCG Antikörper) neurons likely stimulate separate populations of downstream cells to produce a change in food intake and glucose homeostasis and that these effects depend on the metabolic state of the animal.
Together, our data indicate effects of AgoPAMs that go beyond glucose lowering previously observed with GPR40 (zeige FFAR1 Antikörper) partial agonist treatment with additional potential for weight loss.
pancreatic reactivation of Gcg (zeige GCG Antikörper) fully restored the effect of exendin-[9-39] to impair both oral and intraperitoneal glucose tolerance.
The protein encoded by this gene is actually a preproprotein that is cleaved into four distinct mature peptides. One of these, glucagon, is a pancreatic hormone that counteracts the glucose-lowering action of insulin by stimulating glycogenolysis and gluconeogenesis. Glucagon is a ligand for a specific G-protein linked receptor whose signalling pathway controls cell proliferation. Two of the other peptides are secreted from gut endocrine cells and promote nutrient absorption through distinct mechanisms. Finally, the fourth peptide is similar to glicentin, an active enteroglucagon.
, glucagon-like peptide 1
, glucagon-like peptide 2
, glucagon-like peptide I