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GTF2I encodes a multifunctional phosphoprotein with roles in transcription and signal transduction. Zusätzlich bieten wir Ihnen GTF2I Proteine (5) und viele weitere Produktgruppen zu diesem Protein an.
Showing 10 out of 125 products:
Dog (Canine) Monoclonal GTF2I Primary Antibody für IF, WB - ABIN968264
Yang, Desiderio: BAP-135, a target for Bruton's tyrosine kinase in response to B cell receptor engagement. in Proceedings of the National Academy of Sciences of the United States of America 1997
Human Polyclonal GTF2I Primary Antibody für ICC, IF - ABIN4358737
Lopez-Contreras, Ruppen, Nieto-Soler, Murga, Rodriguez-Acebes, Remeseiro, Rodrigo-Perez, Rojas, Mendez, Muñoz, Fernandez-Capetillo: A proteomic characterization of factors enriched at nascent DNA molecules. in Cell reports 2013
Cow (Bovine) Polyclonal GTF2I Primary Antibody für IHC, WB - ABIN2787508
Ewing, Chu, Elisma, Li, Taylor, Climie, McBroom-Cerajewski, Robinson, OConnor, Li, Taylor, Dharsee, Ho, Heilbut, Moore, Zhang, Ornatsky, Bukhman, Ethier, Sheng, Vasilescu, Abu-Farha, Lambert, Duewel et al.: Large-scale mapping of human protein-protein interactions by mass spectrometry. ... in Molecular systems biology 2007
Human Monoclonal GTF2I Primary Antibody für IF, IHC (p) - ABIN561180
Poitras, Yu, Lesage-Pelletier, Macdonald, Gagné, Hatch, Kelly, Hamilton, Rubenstein, Poirier, Ekker: An SNP in an ultraconserved regulatory element affects Dlx5/Dlx6 regulation in the forebrain. in Development (Cambridge, England) 2010
GTF2I/Gtf2i, its physiologic role in human disorders was relatively unknown until recently. Novel studies show that it is involved in an array of human diseases including neurocognitive disorders, systemic lupus erythematosus (SLE), and cancer.
the results reported here support a model whereby common genetic variation in GTF2I mediates human sociality and anxiety via effects on oxytocin reactivity.
GTF2I mutations common in thymic epithelial tumors are not present/uncommon in hematological malignancies.
The mis-regulation of genes downstream of GTF2IRD1, including TbetaR2 and BMPR1b, also individually promoted mammary cancer development, and silencing of TbetaR2 suppressed GTF2IRD1-driven tumor promotion.
a new BRAF (zeige BRAF Antikörper) fusion in pilocytic astrocytoma
A common polymorphism in the Williams syndrome gene GTF2I associated with reduced social anxiety predicts decreased threat-related amygdala reactivity, which mediates an association between genotype and increased warmth in women.
We identified rs117026326 on GTF2I with GWAS significance (P = 1.10 x 10(-15)) and rs13079920 on RBMS3 (zeige RBMS3 Antikörper) with suggestive significance (P = 2.90 x 10(-5)) associating with Primary Sjogren's syndrome in women.
The authors found that human adenovirus 5 infection or ectopic E4-ORF3 (zeige ASZ1 Antikörper) expression leads to SUMOylation of TFII-I that precedes a rapid decline in TFII-I protein levels.
A novel interaction between TFII-I and Mdm2 (zeige MDM2 Antikörper) with a negative effect on TFII-I transcriptional activity has been documented.
Copy-number variation in the general transcription factor gene, GTF2I is associated with gene-dose-dependent anxiety in mouse models and in both Williams syndrome and Dup7.
The Cre-mediated deletion of exon 3 recapitulates a genetic null phenotype, indicating that the conditional Gtf2i line is a valuable tool for studying TFII-I function during embryonic development
found a highly conserved DNA element, common to a set of genes regulated by TFII-I, and identified and validated novel in vivo neuronal targets of this protein affecting the PI3K and TGFbeta (zeige TGFB1 Antikörper) signaling pathways
GTF2IRD2 (zeige GTF2IRD2 Antikörper) has evolved as a regulator of GTF2IRD1 and TFII-I; inhibiting their function by direct interaction and sequestration into inactive nuclear zones.
data support the hypothesis that upregulation of TFII-I factors leads to activation of a specific group of developmental genes during mESC differentiation
GTF2I duplication results in separation anxiety in mice and humans
In order to clarify the involvement of GTF2I in neurocognitive function, especially social behavior, we have developed and characterized Gtf2i-deficient mice.
Results suggest that DJ-1 (zeige PARK7 Antikörper) together with TFII-I operate in concert to cope with various insults and to sustain pancreatic beta-cell function.
behavioral characterization of heterozygous mice with a deletion of the first 140 amino-acids of TFII-I.
data demonstrate that TFII-I, through a Src (zeige SRC Antikörper)-dependent mechanism, reversibly translocates from the cytoplasm to the nucleus, leading to the transcriptional activation of growth-regulated genes
acts as a transcriptional cofactor for the SUMO ubiquitin-protein isopeptide ligase family member Miz1/PIASxbeta /Siz2 (zeige PIAS2 Antikörper)
The protein encoded by this gene contains five GTF2I-like repeats and each repeat possesses a potential helix-loop-helix (HLH) motif. It may have the ability to interact with other HLH-proteins and function as a transcription factor or as a positive transcriptional regulator under the control of Retinoblastoma protein. This gene plays a role in craniofacial and cognitive development and mutations have been associated with Williams-Beuren syndrome, a multisystem developmental disorder caused by deletion of multiple genes at 7q11.23. Alternative splicing results in multiple transcript variants.
BTK-associated protein, 135kD
, Bruton tyrosine kinase-associated protein 135
, SRF-Phox1-interacting protein
, Williams-Beuren syndrome chromosome region 6
, general transcription factor II-I
, USE B1-binding protein
, Williams-Beuren syndrome chromosome region 11
, binding factor for early enhancer
, general transcription factor 3
, general transcription factor II-I repeat domain-containing protein 1
, general transcription factor III
, muscle TFII-I repeat domain-containing protein 1 alpha 1
, slow-muscle-fiber enhancer-binding protein
, williams-Beuren syndrome chromosomal region 12 protein
, BTK-associated protein 135
, general transcription factor II, i
, general transcription factor IIi L homeolog
, general transcription factor IIi S homeolog