anti-Gap Junction Protein, gamma 2, 47kDa (GJC2) Antikörper

GJC2 encodes a gap junction protein. Zusätzlich bieten wir Ihnen Gap Junction Protein, gamma 2, 47kDa Proteine (6) und und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
GJC2 118454 Q8BQU6
GJC2 497913 Q80XF7
GJC2 57165 Q5T442
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Top anti-Gap Junction Protein, gamma 2, 47kDa Antikörper auf antikoerper-online.de

Showing 10 out of 36 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Kaninchen Unkonjugiert IHC, WB WB Suggested Anti-GJC2 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:312500  Positive Control:  MCF7 cell lysate WB Suggested Anti-GJC2 antibody Titration: 1 ug/mL Sample Type: Human liver 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Human Kaninchen Unkonjugiert WB 100 μg Anmelden zum Anzeigen 4 bis 6 Tage
$240.00
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Fledermaus Kaninchen Unkonjugiert WB 50 μg Anmelden zum Anzeigen 7 bis 9 Tage
$551.83
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Human Kaninchen Unkonjugiert ELISA, IF, WB 100 μL Anmelden zum Anzeigen 16 Days
$181.73
Details
Human Kaninchen Unkonjugiert ELISA, ICC, IF, WB Western blot analysis of Mouse fetal muscle lysate, using GJC2 Antibody. The lane on the left is treated with the antigen-specific peptide. ABIN6277351 staining A549 by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100,then blocked in 10% serum for 45 minutes at 25¡ãC. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37¡ãC. An  Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) Ab, diluted at 1/600, was used as the secondary antibod 100 μL Anmelden zum Anzeigen 11 bis 12 Tage
$390.77
Details
Human Kaninchen Unkonjugiert IHC, WB Immunohistochemistry: GJC2 Antibody [NBP1-59263] - Formalin Fixed Paraffin Embedded Tissue: Human Adult heart Observed Staining: Membrane, some cytoplasm Primary Antibody Concentration: 1:100 Secondary Antibody: Donkey anti-Rabbit-Cy2/3 Secondary Antibody Concentration: 1:200 Magnification: 20X Exposure Time: 0.5 - 2.0 sec Protocol located in Reviews and Data. Western Blot: GJC2 Antibody [NBP1-59263] - Analysis of 293T cell lysate. Antibody Dilution: 1.0 ug/ml GJC2 is supported by BioGPS gene expression data to be expressed in HEK293T. 100 μL Anmelden zum Anzeigen 8 bis 11 Tage
$485.88
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Human Kaninchen Unkonjugiert WB Western blot analysis of extracts of Mouse brain tissue, using GJC2 antibody. 100 μL Anmelden zum Anzeigen 16 Days
$334.77
Details
Human Maus Unkonjugiert WB GJC2 Antibody (N-term)  western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the GJC2 antibody detected the GJC2 protein (arrow). 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$335.50
Details
Human Maus Unkonjugiert WB GJC2 Antibody (N-term)  western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the GJC2 antibody detected the GJC2 protein (arrow). 0.1 mL Anmelden zum Anzeigen 10 bis 11 Tage
$335.50
Details
Human Maus Unkonjugiert WB 100 μL Anmelden zum Anzeigen 7 bis 9 Tage
$463.83
Details

Weitere Antikörper gegen Gap Junction Protein, gamma 2, 47kDa Interaktionspartner

Mouse (Murine) Gap Junction Protein, gamma 2, 47kDa (GJC2) Interaktionspartner

  1. Main findings are that i) Cx47 is involved in the reversal of acute increases in serum triglycerides, ii) serum lipid levels of mice on chow but not high-cholesterol diet are affected by Cx47 and iii) Cx47-deficiency tends to increase plaque size but decreases macrophage content of diet-induced atherosclerotic plaques. Results show that Cx47-deficient mice do not display an overt lymphatic phenotype.

  2. Data show that segregation of Foxc2 (zeige FOXC2 Antikörper) and NFATc1 (zeige NFATC1 Antikörper) transcription factor is closely associated with the highly polarized expression of connexins Cx37 (zeige GJA4 Antikörper), Cx43 (zeige GJA1 Antikörper), and Cx47.

  3. This study demonistrated that Cx30 (zeige GJB6 Antikörper)/Cx47 double-deficient mice has the functional role of both connexins for interastrocytic, interoligodendrocytic, and panglial coupling, and show that both connexins are required for maintenance of myelin.

  4. PMLD1 (Pelizaeus-Merzbacher-like disease 1) is caused by the loss of Cx47 channel function that results in impaired panglial coupling in white matter tissue.

  5. oligodendrocyte-astrocyte gap junction coupling in Cx32 (zeige GJB1 Antikörper) or Cx47 knockout mice. In the neocortex, oligodendrocytes appeared to be directly and exclusively coupled to astrocytes; Cx47, but not Cx32 (zeige GJB1 Antikörper), was required for O:A coupling.

  6. oligodendrocytes in white matter form a functional syncytium predominantly among each other dependent on Cx47 and Cx32 (zeige GJB1 Antikörper) expression, while astrocytic connexins expression can promote the size of this network

  7. Cx47-deficient mice revealed a vacuolation of nerve fibers at the site of the optic nerve where axons are first contacted by oligodendrocytes and myelination starts; Cx32 (zeige GJB1 Antikörper)/Cx47-double-deficient mice developed action tremor and died ca 51 d after birth

  8. Mice lacking either Cx47 or Cx32 (zeige GJB1 Antikörper) are viable but mice lacking both connexins die by postnatal week 6 from CNS myelin sheath abnormalities, vacuolation, enlarged periaxonal collars, oligodendrocyte cell death, and axonal loss

  9. All oligodendrocytes appear to express Cx47, which is largely restricted to their perikarya

  10. These results demonstrate MUPP1 (zeige MPDZ Antikörper) at O/A gap junctions and Cx47-dependent targeting of connexins to the plasma membranes of oligodendrocyte somata.

Human Gap Junction Protein, gamma 2, 47kDa (GJC2) Interaktionspartner

  1. Different mutations in the Cx47 lead to discrepant activation of unfolded protein response (UPR) pathway, which encouraged apoptotic cell death at different levels. Inappropriate activation of UPR may play important roles in the pathophysiology of Pelizaeus-Merzbacher-Like Disease.

  2. GJC2 promoter region mutation screening should be included in the evaluation of patients with unexplained hypomyelinating leukodystrophies.

  3. we provide evidence that a mutation in GJA1 (zeige GJA1 Antikörper) leads not only to ODD as already described in the literature, but can also lead to lymphoedema as an associated feature.

  4. a novel homozygous mutation in GJC2 was identified in a 21-year-old female patient with Pelizaeus-Merzbacher-like disease

  5. This study identified novel chromosomal rearrangements proximal and distal to, and exclusive of the PLP1 (zeige PLP1 Antikörper) gene, showed equal frequencies of PLP1 (zeige PLP1 Antikörper) and GJA12/GJC2 mutations

  6. Most of the Pelizaeus-Merzbacher-like disease (PMLD)-linked Cx47 mutants disrupt Cx47/Cx47 and Cx47/Cx43 (zeige GJA1 Antikörper) GJ function in the glial network, which may play a role in leading to PMLD symptoms

  7. the extremely severe clinical Pelizaeus-Merzbacher-like disease form likely correlates with the predicted impairment of gap junction channel assembly resulting from the detrimental effect of the new p.Glu260Lys mutant allele on Cx47 protein

  8. founder mutation c.-167A>G localized in the GJC2 protein promoter region in patients with Pelizaeus Merzbacher disease and Pelizaeus Merzbacher like disease

  9. Cx47 mutations were identified in individuals having secondary lymphedema following breast cancer treatment; these novel mutations are dysfunctional and provide evidence that altered gap junction function leads to lymphedema

  10. We report the identification of the GJC2 promoter mutation (c.-167A>G) in nine patients from three unrelated Pakistani families with Pelizaeus-Merzbacher-like disease. Linkage analysis was consistent with a likely founder effect of this mutation

Cow (Bovine) Gap Junction Protein, gamma 2, 47kDa (GJC2) Interaktionspartner

  1. AQP-0 (zeige MIP Antikörper) and connexins can be segregated in the membrane by protein-lipid interactions as modified by AQP-0 (zeige MIP Antikörper) homo-oligomerization

Gap Junction Protein, gamma 2, 47kDa (GJC2) Antigen-Profil

Protein Überblick

This gene encodes a gap junction protein. Gap junction proteins are members of a large family of homologous connexins and comprise 4 transmembrane, 2 extracellular, and 3 cytoplasmic domains. This gene plays a key role in central myelination and is involved in peripheral myelination in humans. Defects in this gene are the cause of autosomal recessive Pelizaeus-Merzbacher-like disease-1.

Genbezeichner und Symbole assoziert mit GJC2

  • gap junction protein gamma 2 (GJC2) Antikörper
  • gap junction protein gamma 2 (gjc2) Antikörper
  • si:dkey-91f15.1 (si:dkey-91f15.1) Antikörper
  • gap junction protein, gamma 2 (Gjc2) Antikörper
  • B230382L12Rik Antikörper
  • CX46.6 Antikörper
  • Cx47 Antikörper
  • Gja12 Antikörper
  • HLD2 Antikörper
  • LMPH1C Antikörper
  • MGC146420 Antikörper
  • PMLDAR Antikörper
  • SPG44 Antikörper

Bezeichner auf Proteinebene für GJC2

gap junction protein, gamma 2, 47kDa , connexin46.6 , gap junction protein, alpha 12, 47kDa , gap junction protein, gamma 12, 47kDa , connexin 46.6 , connexin 44.2 , connexin 47 type A , connexin 47 type C , connexin 47 type D , connexin-47 , gap junction alpha-12 protein , gap junction gamma-2 protein , gap junction membrane channel protein alpha 12 , gap junction protein, chi 2 , gap junction protein, alpha 12 , connexin-46.6

GENE ID SPEZIES
695161 Macaca mulatta
739535 Pan troglodytes
779802 Xenopus (Silurana) tropicalis
100034658 Danio rerio
118454 Mus musculus
497913 Rattus norvegicus
57165 Homo sapiens
538745 Bos taurus
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