anti-GLI-Kruppel Family Member GLI3 (GLI3) Antikörper

GLI3 encodes a protein which belongs to the C2H2-type zinc finger proteins subclass of the Gli family.

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GLI3 2737 P10071
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Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Maus Unkonjugiert EIA, IHC (fro)   0.5 mg Anmelden zum Anzeigen 6 bis 8 Tage
$467.50
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Human Maus Unkonjugiert ELISA, IHC   500 μg Anmelden zum Anzeigen 11 bis 12 Tage
$517.50
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GLI3 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität
Human ,


Weitere Antikörper gegen GLI3 Interaktionspartner

Human GLI-Kruppel Family Member GLI3 (GLI3) Interaktionspartner

  1. A novel GLI3 missense variant in a family that caused a spectrum of digital anomalies. All affected individuals that were tested harbored a c.1826G>A (p.(Cys609Tyr)) variant in GLI3. Functional studies of the murine p.Cys609Tyr GLI3 showed that the mutant protein is not efficiently processed to GLI3R, resulting in a full-length protein with basal transcriptional activity and submaximal pathway activation.

  2. Hedgehog (zeige SHH Antikörper) pathway dysregulation contributes to the pathogenesis of human gastrointestinal stromal tumors via GLI (zeige GLI1 Antikörper)-mediated activation of KIT expression.

  3. The c.480dupC of the GLI3 gene probably underlies the synpolydactyly in this family.

  4. Methylation at K436 and K595 respectively by Set7 (zeige SETD7 Antikörper) increases the stability and DNA binding ability of Gli3, resulting in an enhancement of Shh (zeige SHH Antikörper) signaling activation.

  5. Data suggest that negative feedback mediated by GLI3 (GLI (zeige GLI1 Antikörper)-Kruppel family member) acts to finely tune SHH (sonic hedgehog (zeige SHH Antikörper)) signaling. During medulloblastoma (MB) formation, nerve tissue cells appear to express nestin (zeige NES Antikörper) which hyperactivates SHH (zeige SHH Antikörper) signaling by abolishing negative feedback by GLI3. Restoration of intrinsic negative feedback by repressing nestin (zeige NES Antikörper) expression represents a promising approach to treat MB. [REVIEW]

  6. the first report of the assessment of the frequency of GLI3/SHH (zeige SHH Antikörper)/preZRS/ZRS in Chinese polydactyly patients to show any higher possibility of mutations or variants for the 4 genes or sequences in China

  7. Gli3 and Teashirt3 (zeige ZNF537 Antikörper) might play an important role in the normal development of the ureter.

  8. a novel GLI3 mutation c.714T>A (p.Y238*) was identified in a Chinese family with pre-axial polydactyly. Our results broadened the phenotypic spectrum of GLI3 mutations and demonstrated the feasibility of WES in clinical application of molecular diagnosis.

  9. we describe an ~5 kb deletion within the SHH (zeige SHH Antikörper) repressor GLI3 in two patients with bilateral tibial hemimelia. This deletion results in a truncated GLI3 protein that lacks a DNA-binding domain and cannot repress hedgehog (zeige SHH Antikörper) signaling.

  10. 2 independent cases of GLI3 morphopathies presented: one is a familial case of Greig Cephalopolysyndactyly Syndrome and the other a non-syndromic case of post-axial polydactyly, both are caused due to a truncation mutation at C-terminal of GLI3

GLI3 Antigen-Profil

Protein Überblick

This gene encodes a protein which belongs to the C2H2-type zinc finger proteins subclass of the Gli family. They are characterized as DNA-binding transcription factors and are mediators of Sonic hedgehog (Shh) signaling. The protein encoded by this gene localizes in the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression. It is also thought to play a role during embryogenesis. Mutations in this gene have been associated with several diseases, including Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, preaxial polydactyly type IV, and postaxial polydactyly types A1 and B.

Genbezeichner und Symbole assoziert mit GLI3

  • GLI family zinc finger 3 (GLI3) Antikörper
  • ACLS Antikörper
  • GCPS Antikörper
  • GLI3-190 Antikörper
  • GLI3FL Antikörper
  • PAP-A Antikörper
  • PAPA Antikörper
  • PAPA1 Antikörper
  • PAPB Antikörper
  • PHS Antikörper
  • PPDIV Antikörper

Bezeichner auf Proteinebene für GLI3

GLI-Kruppel family member GLI3 , glioma-associated oncogene family zinc finger 3 , oncogene GLI3 , transcriptional activator GLI3 , zinc finger protein GLI3

GENE ID SPEZIES
2737 Homo sapiens
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