Fragile Histidine Triad (FHIT) ELISA Kits

FHIT, a member of the histidine triad gene family, encodes a diadenosine 5',5'''-P1,P3-triphosphate hydrolase involved in purine metabolism. Zusätzlich bieten wir Ihnen FHIT Antikörper (150) und FHIT Proteine (25) und viele weitere Produktgruppen zu diesem Protein an.

list all ELISA KIts Gen GeneID UniProt
FHIT 2272 P49789
FHIT 60398 Q9JIX3
FHIT 14198 O89106
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Katalog Nr. Reaktivität Sensitivität Bereich Bilder Menge Anbieter Lieferzeit Preis Details
Human 7.8 pg/mL 31.2-2000 pg/mL Typical standard curve 96 Tests Anmelden zum Anzeigen 15 bis 18 Tage
Maus < 0.094 ng/mL 0.156 ng/mL - 10 ng/mL   96 Tests Anmelden zum Anzeigen 11 bis 18 Tage
Ratte < 46.9 pg/mL 78 pg/mL - 5000 pg/mL   96 Tests Anmelden zum Anzeigen 11 bis 18 Tage
Rind (Kuh)
  96 Tests Anmelden zum Anzeigen 15 bis 18 Tage

Weitere ELISA Kits für FHIT Interaktionspartner

Human Fragile Histidine Triad (FHIT) Interaktionspartner

  1. Fhit expression impacts the translation of a number of cancer associated genes.

  2. overexpression of Fhit, a tumor suppressor protein, induces autophagy in NSCLC cells. Further, we found that this autophagy is mediated by 14-3-3tau and plays a cytoprotective role against the antitumor effect of Fhit both in vitro and in vivo.

  3. Review/Meta-analysis: significant difference in FHIT gene promoter methylation status in non-small cell lung carcinoma patients was found in Asians but not in Caucasian population.

  4. these results show that squamous cell carcinomas of the vulva presents a characteristic molecular pattern with FHIT being downregulated whereas HMGA2 is upregulated

  5. It has been proposed that Fhit and Wwox (zeige WWOX ELISA Kits) loss work synergistically in cancer progression and that DNA damage caused by Fhit could be targeted early in cancer initiation for prevention, while DNA damage caused by Wwox (zeige WWOX ELISA Kits) loss could be targeted later in cancer progression, particularly in cancers that develop resistance to genotoxic therapies. (Review)

  6. Two variants were identified for maximal voluntary ventilation and located in the genes of LOC102724340 (rs41434646) and FHIT (rs9833533). FHIT represses transcriptional activity of beta-catenin (zeige CTNNB1 ELISA Kits), a critical protein for growth of skeletal muscle, and thus might have influenced the level of maximal voluntary ventilation.

  7. This study demonstrates that Fhit down-regulation is an early event in both multistep carcinogenic processes leading to pancreatic ductal adenocarcinoma

  8. The results have implications for the mechanism by which Fhit regulates TK1 (zeige TK1 ELISA Kits) mRNA, and more broadly, for its modulation of multiple functions as tumor suppressor/genome caretaker.

  9. RARb and FHIT promoter methylation may be associated with the carcinogenesis of cervical cancer. FHIT promoter methylation may play a crucial role in cervical cancer progression. Additional studies with large sample sizes are essential to confirm our findings.

  10. The peptide was located within the 'disordered' region, which is invisible in the known crystal structures of Fhit.

Cow (Bovine) Fragile Histidine Triad (FHIT) Interaktionspartner

  1. the same mRNA isoforms of FHIT were detected in bladder tumors and in healthy tissues, including a novel isoform that was found in this study, suggesting that epigenetic modifications and altered expression profiles are not a hallmark of vesical tumors

Mouse (Murine) Fragile Histidine Triad (FHIT) Interaktionspartner

  1. Fhit loss and subsequent thymidine kinase 1 (zeige TK1 ELISA Kits) inactivation, combined with selective pressures, leads to neoplasia-associated alterations in genes and gene expression patterns in vitro and in vivo

  2. Fhit-deficiency mutation signature also resembles a C>T and T>C mutation signature reported for human papillary kidney cancers and a similar signature recently reported for esophageal and bladder cancers, cancers that are frequently Fhit deficient.

  3. Fhit deficiency-induced global genome instability promotes mutation and clonal expansion

  4. Fhit delocalizes annexin A4 (zeige ANXA4 ELISA Kits) from plasma membrane to cytosol and sensitizes lung cancer cells to paclitaxel.

  5. FHIT gene is a "caretaker gene" necessary for maintenance of genome stability.

  6. Loss of Fhit expression contributes to cell transformation.

  7. Defects in Fhit expression may promote MHC-I down-regulation in cancer cells and allow escape from immunosurveillance.

  8. Human and mouse orthologous genes, FHIT and Fhit, are more highly conserved through evolution than PTPRG/Ptprg (zeige PTPRG ELISA Kits) and yet contain more sequence elements that are exquisitely sensitive to genomic rearrangements

  9. Association of Fhit gene inactivation with increased survival after DNA damage, related to over-active checkpoints regulated by ATR/CHK1 pathway. Potential effects of Fhit-dependent DNA damage response on tumor progression.

  10. Fhit has a role in bladder cancer development

FHIT Antigen-Profil

Beschreibung des Gens

This gene, a member of the histidine triad gene family, encodes a diadenosine 5',5'''-P1,P3-triphosphate hydrolase involved in purine metabolism. The gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts of this gene. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. Alternatively spliced transcript variants have been found for this gene.

Genbezeichner und Symbole assoziert mit FHIT

  • fragile histidine triad (FHIT) Antikörper
  • fragile histidine triad (Fhit) Antikörper
  • fragile histidine triad gene (fhit) Antikörper
  • fragile histidine triad gene (Fhit) Antikörper
  • fragile histidine triad (fhit) Antikörper
  • fragile histidine triad protein (PY07476) Antikörper
  • fragile histidine triad L homeolog (fhit.L) Antikörper
  • AP3Aase Antikörper
  • AW045638 Antikörper
  • FHIT Antikörper
  • FRA3B Antikörper
  • Fra14A2 Antikörper
  • LOC100223655 Antikörper
  • zgc:73176 Antikörper

Bezeichner auf Proteinebene für FHIT

AP3A hydrolase , bis(5'-adenosyl)-triphosphatase , diadenosine 5',5'''-P1,P3-triphosphate hydrolase , dinucleosidetriphosphatase , tumor suppressor protein , AP3Aase , fragile histidine triad protein , fragile histidine triad gene , diadenosine triphosphate hydrolase , fragile histidine triad

2272 Homo sapiens
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60398 Rattus norvegicus
100307043 Ovis aries
393713 Danio rerio
14198 Mus musculus
448702 Xenopus (Silurana) tropicalis
100223655 Taeniopygia guttata
3800584 Plasmodium yoelii yoelii 17XNL
416071 Gallus gallus
495983 Xenopus laevis
700974 Macaca mulatta
747260 Pan troglodytes
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