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FCRLA encodes a protein similar to receptors for the Fc fragment of gamma immunoglobulin (IgG). Zusätzlich bieten wir Ihnen Fc Receptor-Like A Proteine (5) und viele weitere Produktgruppen zu diesem Protein an.
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This first genome-wide association approach for cyclophosphamide response in lupus nephritis patients yielded a robust profile of genetic associations including large-effect SNP in the FCGR2B-FCRLA locus, which may provide better insights to cyclophosphamide metabolism and efficacy.
FCGR2C SNPs that associated with vaccine efficacy in RV144 also strongly associated with the expression of FCGR2A (zeige FCGR2A Antikörper)/C and one of them also associated with the expression of Fc receptor-like A (FCRLA), another Fc-gamma receptor (zeige FCGR1A Antikörper) (FcgammaR) gene
alternative splicing of FCRLA mRNA results in the production of isoforms differing by their domain composition and possessing either the short or long signal peptide.
The studies reported here demonstrate that FCRLA is more broadly expressed among human B lineage cells than originally reported; it is found at significant levels in resting blood B cells and at varying levels in all B-cell subsets in tonsil.
Analysis of human cell lines has confirmed that FcRLA is not secreted but is maintained as an intracellular protein in B cells where it interacts with immunoglobulins.
The concentration of FREB FCRL in patients with rheumatoid arthritis is three times higher than in healthy adults.
FCRL/FREB may function in melanocytes and melanoma and may be useful for development of diagnostic methods for various pigment disorders and immunotherapy of melanoma.
High expression of FCRLA in subset(s) of terminally differentiated B-cells suggests that, being an ER protein, FCRLA may participate in the regulation of immunoglobulin assembly and secretion.
FcRLA protein is expressed exclusively in all mouse B cells, where it plays a role in immunoglobulin assembly that can be compensated for by other proteins.
may function as a secreted or intracellular protein (zeige CKAP2 Antikörper) in normal and neoplastic B cells
murine FCRLA (mFCRLA) is expressed and distributed in murine tissues similar to hFCRLA
This gene encodes a protein similar to receptors for the Fc fragment of gamma immunoglobulin (IgG). These receptors, referred to as FCGRs, mediate the destruction of IgG-coated antigens and of cells induced by antibodies. This encoded protein is selectively expressed in B cells, and may be involved in their development. This protein may also be involved in the development of lymphomas. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene.
Fc receptor homolog expressed in B cells (FREB)
, Fc receptor related protein X
, Fc receptor-like and mucin-like 1
, fc receptor homolog expressed in B-cells
, fc receptor-like and mucin-like protein 1
, fc receptor-like protein
, fc receptor-related protein X
, Fc receptor related X
, Fc receptor-like mucin-like 1
, Fc receptor homolog expressed in B cells