Fc Receptor, IgG, Low Affinity IV Proteine (FCGR4)

Receptor for the Fc region of immunoglobulin gamma (PubMed:16039578). Zusätzlich bieten wir Ihnen Fc Receptor, IgG, Low Affinity IV Antikörper (11) und und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
FCGR4 246256 A0A0B4J1G0
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Human Cells Maus His tag 100 μg Anmelden zum Anzeigen 14 bis 16 Tage
$440.65
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Human Cells Maus His tag   10 μg Anmelden zum Anzeigen 15 bis 16 Tage
$225.00
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FCGR4 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Mouse (Murine)
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Weitere Proteine zu Fc Receptor, IgG, Low Affinity IV (FCGR4) Interaktionspartnern

Mouse (Murine) Fc Receptor, IgG, Low Affinity IV (FCGR4) Interaktionspartner

  1. Fc gammaRIV (FcgammaRIV) mediates bone erosion in antigen-induced arthritis (AIA) by inducing the influx of S100A8/A9-producing neutrophils into the arthritic joint.

  2. The IgG2 immune complexes activates osteoclastogenesis by binding to FcgammaRIThe IgG2 immune complexes activates osteoclastogenesis by binding to FcgammaRIV.

  3. antibody orchestrated Fcgamma receptor-mediated switch in inflammation is one mechanism underlying inhibition of axon regeneration

  4. The human natural killer cytotoxic cell line NK-92, once armed with a murine CD16 receptor, represents a convenient cellular tool for the screening of mouse mAbs according to their ADCC potential.

  5. FcgammaRIV expression and function on osteoclasts during the steady state and during acute joint inflammation in a model of inflammatory arthritis

  6. The mechanism(s) of phagocytosis in the second phase of blood incompatibility reaction required neither C3 nor FcgammaRs.

  7. Our findings both genetically and functionally identify a novel disease-related molecule, FcgammaRIV, in an autoantibody-mediated disorder, which may be of importance for the development of novel targeted therapies.

  8. Two activating IgG receptors, FcgammaRIIIA and FcgammaRIV, expressed in mast cells are responsible for serum-induced passive arthritis in wild type mice.

  9. a variety of IgG2a- and IgG2b-dependent effector functions are impaired in the absence of Fcgr4 in models of autoimmunity and antibody-dependent cellular cytotoxicity.

  10. Identification of its gene

  11. Fc gammaRIV (Fc fragment of IgG, low affinity IIIa, receptor) is restricted to myeloid lineage cells, and binds to IgG2a and IgG2b with intermediate affinity.

  12. The length of the stalk region of the alpha-chain is an important determinant of Fc gamma receptor IIIA stability on the cell surface.

  13. FcgammaRIV requires association of the FcR gamma-chain for optimal expression and function on myeloid cells.

  14. The respective roles of FcgammaRI, FcgammaRIII, and FcgammaRIV in in the development of autoimmune hemolytic anemia were shown.

  15. Cooperative FcgammaRIV, FcgammaRIII, and FcgammaRI interactions mediated optimal lymphoma depletion by CD20 mAb in vivo.

  16. Fcgr4 is a mouse IgE receptor that resembles macrophage MS4A2 protein in humans and promotes IgE-induced lung inflammation.

  17. Required for both neutrophil influx and glomerular inflammation induced by switch-variant nephrotoxic IgG2a and IgG2b monoclonal antibodies.

  18. Results demonstrate a combined requirement for FcgammaRIII and FcgammaRIV in autoimmune injury, and identify the linker for activation of T cells adaptor as an integral component of linked FcgammaR and C5a activation to generate inflammation.

Fc Receptor, IgG, Low Affinity IV (FCGR4) Protein Überblick

Protein Überblick

Receptor for the Fc region of immunoglobulin gamma (PubMed:16039578). Also acts as a receptor for the Fc region of immunoglobulin epsilon (PubMed:17558411, PubMed:18949059). Binds with intermediate affinity to both IgG2a and IgG2b (PubMed:16039578, PubMed:17558411, PubMed:19795417). Can bind to IgG2a and IgG2b monomers (PubMed:18949059). Does not display binding to IgG1 or IgG3 (PubMed:16039578). Mediates neutrophil activation by IgG complexes redundantly with Fcgr3 (PubMed:18097064). Plays a role in promoting bone resorption by enhancing osteoclast differentiation following binding to IgG2a (PubMed:25824719). Binds with low affinity to both the a and b allotypes of IgE (PubMed:18949059). Has also been shown to bind to IgE allotype a only but not to allotype b (PubMed:17558411). Binds aggregated IgE but not the monomeric form and bound monomeric IgG is readily displaced by IgE complexes (PubMed:18949059). Binding to IgE promotes macrophage-mediated phagocytosis, antigen presentation to T cells, production of proinflammatory cytokines and the late phase of cutaneous allergic reactions (PubMed:17558411, PubMed:18949059). {ECO:0000269|PubMed:16039578, ECO:0000269|PubMed:17558411, ECO:0000269|PubMed:18097064, ECO:0000269|PubMed:18949059, ECO:0000269|PubMed:19795417, ECO:0000269|PubMed:25824719}.

Genbezeichner und Symbole assoziert mit FCGR4

  • Fc receptor, IgG, low affinity IV (Fcgr4)
  • 4833442P21Rik Protein
  • CD16-2 Protein
  • FcgammaRIV Protein
  • Fcgr3a Protein
  • FcgRIV Protein
  • Fcrl3 Protein

Bezeichner auf Proteinebene für FCGR4

CD16-2 , Fc fragment of IgG, low affinity IIIa, receptor for (CD16); Fc fragment of IgG, low affinity III, receptor for (CD16) , Fc gammaRIV , Fc receptor-like 3 , FcgammaRIV , low affinity immunoglobulin gamma Fc region receptor III-A , low affinity immunoglobulin gamma Fc region receptor IV

GENE ID SPEZIES
246256 Mus musculus
Ausgewählte Anbieter für Fc Receptor, IgG, Low Affinity IV Proteine (FCGR4)
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