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The Fos gene family consists of 4 members FOSL1, and FOSL2. Zusätzlich bieten wir Ihnen FOSL1 Antikörper (98) und FOSL1 Kits (22) und viele weitere Produktgruppen zu diesem Protein an.
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Fra1 inhibited the protein levels of Bcl2 (zeige BCL2 Proteine), cMyc (zeige MYC Proteine), Survivin (zeige BIRC5 Proteine), and BclxL (zeige BCL2L1 Proteine). Fra1 overexpression in intestinal mucosal epithelial cells may restrain damage repair after intestinal mucosal injury in inflammatory bowel disease remittent period through weakening the protective effect of intestinal mucosa, thus increasing the risk of recurrence.
High FRA1 expression is associated with Esophageal Squamous Cell Carcinoma.
constitutive activation and non-regulation of Fra-1 by bicalutamide in PC-3 (zeige PCSK1 Proteine) cells suggested that Fra-1, probably a key component, involved in transition of aggressive androgen-independent PC-3 (zeige PCSK1 Proteine) cells with poor prognosis.
the overexpression of Fra1 disrupted inflammatory cytokine secretion by medullary thymic epithelial cells in the myasthenia gravis thymus
Taken together, our results indicated that miR (zeige MLXIP Proteine)-449 overexpression inhibited osteogenic differentiation of HG-FFA-treated hBMSCs through the Sirt1 (zeige SIRT1 Proteine)/Fra-1 signal pathway.
These findings indicate that an aberrant Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) signalling leads to the epithelial-mesenchymal transition and drug resistance of glioma via Fra1 induction, which suggests novel therapeutic strategies for the malignant disease.
MUC1 (zeige MUC1 Proteine) enhancement of ERK (zeige EPHB2 Proteine) activation influences FRA-1 activity to modulate tumor migration, invasion and metastasis in a subset of pancreatic cancer cases
the results indicate that FRA1 promotes cancer growth through AKT (zeige AKT1 Proteine), and enhances cancer cell migration through JNK/c-Jun, pinpointing FRA1 as a key integrator of JNK (zeige MAPK8 Proteine) and AKT (zeige AKT1 Proteine) signaling pathways and a potential therapeutic target for squamous cell carcinoma of the skin and head and neck squamous cell carcinoma.
Study shows that FOSL1 is the main immediate early AP-1 (zeige JUN Proteine) member induced by melanoma oncogenes; found that FOSL1 is involved in melanoma cell migration as well as cell proliferation and anoikis-independent growth.
a Fra-1-miR (zeige MLXIP Proteine)-134 axis drives a positive feedback loop that amplifies ERK (zeige EPHB2 Proteine)/JNK (zeige MAPK8 Proteine) signaling and reduces chemosensitivity in ovarian cancer cells.
NF-kappaB (zeige NFKB1 Proteine) and c-Jun (zeige JUN Proteine) coregulate lipopolysaccharide-induced Fra-1 transcription.
Upon stimulation with poly(I:C), malaria parasite-infected red blood cells (iRBCs), or vesicular stomatitis virus (VSV), FOSL1 "translocated" from the nucleus to the cytoplasm, where it inhibited the interactions between TNF receptor-associated factor 3 (TRAF3 (zeige TRAF3 Proteine)), TIR domain-containing adapter inducing IFN-beta (zeige IFNB1 Proteine) (TRIF (zeige RNF138 Proteine)), and Tank-binding kinase 1 (TBK1 (zeige TBK1 Proteine)) via impairing K63-linked polyubiquitination of TRAF3 (zeige TRAF3 Proteine) and TRIF (zeige RNF138 Proteine).
Adipose-derived stromal cells overexpressing Fra-1 effectively protect against osteoarthritis.
Overexpression of Fosl1, which encodes a component of the AP-1 (zeige JUN Proteine) transcription factor complex, in osteoblasts significantly blocked malleal capillary narrowing.
Fra-1 gene expression is activated in response lipopolysaccharide induced lung-injury in mice.
Data suggest that expression of Fra1 (fos-related antigen 1) in preadipocytes is up-regulated by arachidonic acid (AA) during late stages of adipogenesis; however, in early stage of adipogenesis, AA inhibits adipogenesis via Fra1-dependent mechanism.
Fra-1 plays a key role in promoting chronic CS-induced lung macrophagic inflammation in vivo
we demonstrate that Fra1 negatively controls plasma cell differentiation by repressing Blimp1 (zeige PRDM1 Proteine) expression.
observations suggest that MyoD (zeige MYOD1 Proteine) and pRb (zeige PGR Proteine) work together cooperatively at the level of the intronic enhancer of Fra-1 during terminal cell cycle arrest
findings, based on a definitive genetic mouse model provide fundamental insights into mammary duct maturation and homeostasis and reveal that Scrib loss activates a MAPK (zeige MAPK1 Proteine)/Fra1 pathway that alters mammary progenitor activity
The Fos gene family consists of 4 members FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation.
, fos-related antigen 1
, FOS-like antigen 1