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The protein encoded by FKBP5 is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. Zusätzlich bieten wir Ihnen FKBP5 Antikörper (128) und FKBP5 Proteine (13) und viele weitere Produktgruppen zu diesem Protein an.
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These results provide strong evidence of interactions between FKBP5 genotypes and early-life stress, which could pose a significant risk factor for stress-associated disorders such as major depression and post-traumatic stress disorder (PTSD).
FKBP5 polymorphisms in combination with early life stress exposure predict higher insulin (zeige INS ELISA Kits) and glucose values in midlife.
GxE interaction between child maltreatment and FKBP5 on dissociative symptoms in adolescence.
Children with high attachment insecurity and homozygous FKBP5 minor alleles manifest maladaptive emotion regulation and depressive symptoms.
This study demonstrated that FKBP5 Messenger RNA Increases After Adolescence in Human Dorsolateral Prefrontal Cortex.
A novel FKBP5 1V55L mutation is associated with Paget's disease in a Chinese family. Mutant FKBP51V55L promotes osteoclastogenesis.
A negative correlation between basal levels of FKBP5 methylation and serum cortisol was observed.
Study found an additive interaction effect between FKBP5's rs1360780 variant and the graph-theoretical metrics of hippocampal connectivity to influence depression risk. Data reveals alterations of the communication patterns between the hippocampus and the rest of the brain in depression, effects potentially driven by overall familial factors (genes plus shared twin environment) and modified by the FKBP5 gene.
This study demonstrated suggest that FKBP5 in the GR pathway may be a point of vulnerability to early-life adversity, as seen in this group of non-traumatized young adults.
Association of FKBP5 haplotype with risk of suicide attempt.
These data establish SUMO conjugation as a novel regulatory mechanism in the Hsp90 (zeige HSP90 ELISA Kits) cochaperone activity of FKBP51 with a functional impact on GR signaling in a neuronal context.
Findings indicate a role of FK506 binding protein 5 (FKBP5) in hypoxia-regulated adipogenesis.
important regulator of PPARgamma (zeige PPARG ELISA Kits) in white adipose tissue
FKBP5 might increase muscle mass through the enhancements of muscle protein synthesis and myotube differentiation as well as an inhibition of muscle protein degradation in mice
findings show that miR (zeige MLXIP ELISA Kits)-511 is a functional regulator of FKBP5 and can contribute to neuronal differentiation.
These results suggest that the association between FKBP5 and alcohol consumption is conserved in both mice and humans.
We discovered that the suggested psychiatric risk factor FK506 binding protein 51 (FKBP51) increases phosphorylation of GSK3beta at serine 9 (pGSK3beta(S9)).
Results suggest that regulation of Fkbp5 mRNA expression via DNA methylation, and its subsequent regulation of glucocorticoid receptor (zeige NR3C1 ELISA Kits) sensitivity may be implicated in the molecular mechanisms of fear retention and extinciton
the abundance of BDNF (zeige BDNF ELISA Kits) positively correlated and phosphorylated DNMT1 (zeige DNMT1 ELISA Kits) inversely correlated with that of FKBP51 in cells
FKBP5 associates with BECN1 (zeige BECN1 ELISA Kits), changes its phosphorylation and protein levels and enhances markers of autophagy and autophagic flux
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It is thought to mediate calcineurin inhibition. It also interacts functionally with mature hetero-oligomeric progesterone receptor complexes along with the 90 kDa heat shock protein and P23 protein. This gene has been found to have multiple polyadenylation sites. Alternative splicing results in multiple transcript variants.
FK506 binding protein 5
, FK506-binding protein 5
, PPIase FKBP5
, peptidyl-prolyl cis-trans isomerase FKBP5
, 51 kDa FK506-binding protein 5
, 51 kDa FKBP
, 54 kDa progesterone receptor-associated immunophilin
, FF1 antigen
, HSP90-binding immunophilin
, T-cell FK506-binding protein
, androgen-regulated protein 6
, peptidylprolyl cis-trans isomerase
, 51 kDa FK506-binding protein