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FBXO32 encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. Zusätzlich bieten wir Ihnen FBXO32 Kits (30) und FBXO32 Proteine (9) und viele weitere Produktgruppen zu diesem Protein an.
Showing 10 out of 86 products:
Human Polyclonal FBXO32 Primary Antibody für IF (p), IHC (p) - ABIN747698
Lin, Hanson, Betik, Brennan-Speranza, Hayes, Levinger: Hindlimb Immobilization, But Not Castration, Induces Reduction of Undercarboxylated Osteocalcin Associated With Muscle Atrophy in Rats. in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2016
Human Polyclonal FBXO32 Primary Antibody für ELISA, WB - ABIN451805
Hanai, Cao, Tanksale, Imamura, Koshimizu, Zhao, Kishi, Yamashita, Phillips, Sukhatme, Lecker: The muscle-specific ubiquitin ligase atrogin-1/MAFbx mediates statin-induced muscle toxicity. in The Journal of clinical investigation 2007
Atrogin-1 inactivation leads to progressive impairment of heart and skeletal muscle function and structure. Autophagy is severely impaired in Atrogin-1-deficient zebrafish embryos.
Results suggest that the up-regulation of FBXO32 is associated with skeletal and smooth muscle atrophy that occurs during fasting.
role of the muscle specific (zeige EIF3K Antikörper) E3s MuRF-1 (zeige TRIM63 Antikörper) and MAFbx in skeletal muscle wasting during various pathologies, as well as their regulation by modifiable lifestyle factors, were explored (review)
FBXO32 activates NF-kappaB (zeige NFKB1 Antikörper) through IkappaBalpha (zeige NFKBIA Antikörper) degradation in inflammatory and genotoxic stress
Transcriptional analysis of endophilin-A mutant mice, complemented by proteomics, highlighted ataxia- and protein-homeostasis-related genes and revealed upregulation of the E3-ubiquitin ligase (zeige MUL1 Antikörper) FBXO32/atrogin-1 and its transcription factor FOXO3A (zeige FOXO3 Antikörper).
Low FBXO32 expression is associated with breast cancer tumorigenesis.
the involvement of oxidative stress in the atrophy of COPD peripheral muscle cells in vitro, via the FoxO1/MuRF1/atrogin-1 signaling pathway of the ubiquitin/proteasome system
These results have revealed the roles for atrogin-1 in the regulation of smooth muscle contractility through enhancement of myocardin (zeige MYOCD Antikörper) ubiquitylation/degradation and its transcriptional activity.
Our results indicate that abnormal SCF (zeige KITLG Antikörper) activity with subsequent impairment of the autophagic flux due to a novel FBXO32 mutation is implicated in the pathogenesis of Dilated cardiomyopathy .
Our data suggest that FBXO32 is a candidate gene for recessive familial dilated cardiomyopathy. Acting as a cardiac ubiquitin ligase, mutated FBXO32 could perturb the degradation of target proteins in the ubiquitin proteasome system.
Vitamin D3 might have an inhibitory effect on the expression of MAFbx and MuRF1 (zeige TRIM63 Antikörper) in skeletal muscle.
Atrogin-1 expression tended to be increased in the skeletal muscle of patients with malignant disease even before c (zeige TNF Antikörper)ancer related cachexia weight loss.
this study shows that aspartate suppresses lipopolysaccharide-induced MAFbx expression in skeletal muscle via activation of Akt (zeige AKT1 Antikörper) signaling, and inhibition of AMPKa and FOXO1 (zeige FOXO1 Antikörper) signaling
Porcine congenital splayleg (PCS) is a condition characterized by extensive fibre atrophy and raised fibre density. The combined differential expression of MAFbx and P311 (zeige C5orf13 Antikörper) is of potential in the diagnosis of subclinical PCS.
A study on the variability of bovine FBXO32 gene that is predictive of genetic potential for body length phenotype.
Indoxyl sulfate enhanced the production of atrogin-1 by enhancing oxidative stress in skeletal muscle, leading to muscle atrophy.
Valproic acid attenuated muscle wasting and myotube atrophy and reduced C/EBPbeta (zeige CEBPB Antikörper) binding to atrogin1 promoter locus in the myotubes.
educed PABPN1 (zeige PABPN1 Antikörper) levels caused a consistent decline in distal PAS (zeige PASK Antikörper) utilization in the 3'-UTR (zeige UTS2R Antikörper) of a subset of OPMD-dysregulated genes. This alternative PAS (zeige PASK Antikörper) utilization led to up-regulation of Atrogin-1, a key muscle atrophy regulator, but down regulation of proteasomal genes. Additionally reduced PABPN1 (zeige PABPN1 Antikörper) levels caused a reduction in proteasomal activity, and transition in MyHC (zeige MYH13 Antikörper) isotope expression pattern in myofibers.
Iron-induced skeletal muscle atrophy is suggested to involve the E3 ubiquitin ligase (zeige MUL1 Antikörper) mediated by the reduction of Akt (zeige AKT1 Antikörper)-FOXO3a (zeige FOXO3 Antikörper) signaling by oxidative stress.
MAFbx mRNA expression was decreased in old mice relative to adult mice, whereas MuRF1 (zeige TRIM63 Antikörper) mRNA expression was less affected by ageing
Suggest role for atrogin-1 up-regulation in simvastatin-induced heart mitochondria dysfunction.
Atrogin1 was upregulated in cancer cachexia mice. Atrogin1 knockdown protected skeletal muscle cells from TNF-alpha (zeige TNF Antikörper) induced atrophy.
Expression of USP19 (zeige USP19 Antikörper) correlates with that of MuRF1 (zeige TRIM63 Antikörper) and MAFbx/atrogin-1 in skeletal muscles
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and contains an F-box domain. This protein is highly expressed during muscle atrophy, whereas mice deficient in this gene were found to be resistant to atrophy. This protein is thus a potential drug target for the treatment of muscle atrophy. Alternative splicing results in multiple transcript variants encoding different isoforms.
F-box only protein 32
, F-box protein 32
, F-box only protein 32-like
, atrogin 1
, muscle atrophy F-box protein
, atrophy gene 1