Endoglin Proteine (ENG)

ENG encodes a homodimeric transmembrane protein which is a major glycoprotein of the vascular endothelium. Zusätzlich bieten wir Ihnen Endoglin Antikörper (609) und Endoglin Kits (74) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
ENG 2022 P17813
ENG 13805 Q63961
ENG 497010  
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Top Endoglin Proteine auf antikoerper-online.de

Showing 10 out of 53 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Lieferzeit Preis Details
Human Cells Human Fc Tag 50 μg 14 bis 16 Tage
$440.65
Details
Human Cells Maus His tag 100 μg 14 bis 16 Tage
$634.76
Details
Insektenzellen Maus rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg 50 bis 55 Tage
$5,262.31
Details
Insektenzellen Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg 50 bis 55 Tage
$7,493.38
Details
Human Cells Human His tag 50 μg 14 bis 16 Tage
$440.65
Details
Escherichia coli (E. coli) Human His tag,TRX tag   50 μg 4 Days
$385.00
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg 11 Days
$888.80
Details
Baculovirus infected Insect Cells Maus His tag 100 μg 13 bis 16 Tage
$1,230.77
Details
Escherichia coli (E. coli) Human His tag 100 μg 13 bis 16 Tage
$953.85
Details
Wheat germ Human GST tag 10 μg 11 bis 12 Tage
$340.00
Details

ENG Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , , , , ,
, , , , , ,
Mouse (Murine) , , , ,
,
Rat (Rattus)

Am meisten referenzierte Endoglin Proteine

  1. Human ENG Protein expressed in Wheat germ - ABIN1352793 : Banerjee, Dhara, Bacanamwo: Endoglin is a novel endothelial cell specification gene. in Stem cell research 2011 (PubMed)

Weitere Proteine zu Endoglin (ENG) Interaktionspartnern

Human Endoglin (ENG) Interaktionspartner

  1. CD105 expression (MVD) is inversely related to tumor aggressiveness in clear cell renal cell carcinoma and can be used as a favorable prognosis marker.

  2. ENG selectively interacts with sphingomyelin(SM)-18:0 which promotes its clustering with metalloproteinase 14 (MMP14) in SM-18:0 enriched lipid rafts of the apical syncytial membranes from preeclampsia placenta where ENG is cleaved by MMP14 into sENG.

  3. angiogenesis of lung cancer may be related to the interaction of SPARC, TGFbeta1 and Endoglin

  4. Long-term hypercholesterolemia combined with high levels of sEng leads to the aggravation of endothelial and vessel wall dysfunction in aorta, with possible alterations of the membrane endoglin/eNOS signaling.

  5. Plasma level of soluble endoglin is increased in type 2 diabetic patients with diabetic nephropathy.

  6. Study describes a novel mutation in exon 9 of ENG (c.1145G>A) found in five affected members of a family, all of them with characteristic symptoms of hereditary hemorrhagic telangiectasia. This mutation involves Cys382 residue of the Endoglin protein (p.Cys382>Tyr) in the zona pellucida module of its extracellular region.

  7. This review summarizes the current data concerning the role and signalling pathways of endoglin in hepatocellular carcinoma development and progression, and provides an overview of the strategies available for a specific targeting of CD105 in anti-angiogenic therapy in Hepatocellular carcinoma.

  8. Increased sEng and sVCAM-1 and decreased free VEGF plasma levels were found in women with severe preeclampsia, compared with normotensive pregnant group.

  9. circulating soluble Eng can influence vascular development and arteriovenous malformations by modulating angiogenesis.

  10. Data indicate an articulated expression of endoglin/CD105 in acute leukemia, suggesting a therapeutic potential of anti-CD105 monoclonal antibody.

  11. Here we report the genetic characterization and functional analysis of the heterozygous mutation c.-142A>T in the 5'UTR region of ENG found in a family with several members affected by Hereditary hemorrhagic telangiectasia ..Transfection studies in monkey cells using endoglin expression vectors demonstrated that c-142A>T mutation results in a clear reduction in the levels of the endoglin protein.

  12. CD105(+) fibroblasts were found to circumscribe epithelia with neuroendocrine differentiation. CAF-derived SFRP1, driven by CD105 signaling, was necessary and sufficient to induce prostate cancer neuroendocrine differentiation in a paracrine manner.

  13. Combining radiation and CD105 targeting to address the DNA repair.

  14. No correlation was identified between the tumor CD105 (endoglin) expression and survival in CSCC patients treated with radical RT +/- chemotherapy.

  15. Recombinant short-endoglin overexpression reduces unilateral ureteral obstruction-induced renal fibrosis. As long endoglin overexpression provokes renal fibrosis we conclude that endoglin-mediated induction of renal fibrosis in this model is dependent on its cytoplasmic domain.

  16. endoglin promoted VEGF-induced tip cell formation. Mechanistically, endoglin interacted with VEGF receptor (VEGFR)-2 in a VEGF-dependent manner, which sustained VEGFR2 on the cell surface and prevented its degradation. Endoglin mutants deficient in the ability to interact with VEGFR2 failed to sustain VEGFR2 on the cell surface and to promote VEGF-induced tip cell formation.

  17. Endoglin isoforms are differentially upregulated in liver samples of patients with chronic and acute liver injury.

  18. Ki67 LI, CD105, and alpha-SMA expression showed significant differences between normal, low-risk oral epithelial dysplasia and high-risk oral epithelial dysplasia. These findings further support that features such as increased basal cell layer hyperplasia, abnormal superficial mitosis, increased nuclear-cytoplasmic ratio, and hyperchromasia could be transformation-relevant dysplastic features.

  19. Spindle-shaped gastric cancer stromal cells expressing CD73, CD90 or CD105 are involved in disease progression, and among them, CD105-positive cells are strongly associated with poor prognosis.

  20. New results furthermore revealed how Eng affects endothelial cell migration and cell shape control in response to these forces, thereby providing new avenues for our understanding of arteriovenous malformations cause.

Mouse (Murine) Endoglin (ENG) Interaktionspartner

  1. These data reveal a novel function of CD105 in beige adipocytes: maintaining their thermogenic program by regulating Smad2 signaling.

  2. circulating soluble Eng can influence vascular development and arteriovenous malformations by modulating angiogenesis.

  3. endoglin promoted VEGF-induced tip cell formation. Mechanistically, endoglin interacted with VEGF receptor (VEGFR)-2 in a VEGF-dependent manner, which sustained VEGFR2 on the cell surface and prevented its degradation. Endoglin mutants deficient in the ability to interact with VEGFR2 failed to sustain VEGFR2 on the cell surface and to promote VEGF-induced tip cell formation.

  4. Endoglin deficiency in hepatic stellate cell significantly aggravates fibrosis in response to injury in two different murine models of liver fibrosis and increases alpha-SMA and fibronectin expression in vitro.

  5. Transplantation of mesenchymal stem cells, when combined with endothelial progenitor cells, accelerate muscle recovery in a mouse model of hind limb ischemia, through an endoglin-dependent mechanism.

  6. we cannot rule out a possibility that a long-term chronic exposure (9 months and more) to soluble endoglin alone or combined with other cardiovascular risk factors may contribute to alterations of heart function and structure in Sol-Eng+ mice, which is the topic in our lab in ongoing experiments

  7. Data show that concomitant activin receptor-like kinase 1 (Acvrl1) and endoglin (Eng) deficiency synergistically decreases pancreatic neuroendocrine tumor volume.

  8. Endoglin is necessary for the pro-angiogenic properties of the cardiosphere-derived cells secretome.

  9. systemic DPP4 inhibition restores the impaired mononuclear cell homing in Eng+/- animals post-myocardial infarction, and enhances cardiac repair, which might be explained by restoring the balance between the inflammatory and regenerative macrophages present in the heart

  10. results suggest that soluble endoglin modulates inflammatory-related diseases and open new perspectives leading to the development of novel and targeted approaches for the prevention and treatment of cardiovascular diseases

  11. Endoglin controls blood vessel diameter through endothelial cell shape changes in response to haemodynamic cues.

  12. Endoglin prevents vascular malformation by regulating flow-induced cell migration and specification through VEGFR2 signalling.

  13. Identification of novel regulators of developmental hematopoiesis using Endoglin regulatory elements as molecular probes

  14. Endoglin has an important role in VSMC recruitment and blood vessel maturation during angiogenesis.

  15. the TGFbeta1 coreceptor Eng selectively regulates expression of multiple transient receptor potential channels in the setting of left or right ventricular pressure overload

  16. Endothelial cell-specific endoglin expression in islets of Langerhans is sensitive to VEGF and plays partial roles in driving islet vascular development, however such regulation appears to be distinct to mechanisms required to modulate islet viability and size.

  17. Study provides evidence that the expression of endoglin is required for the establishment of uterine receptivity and the decidualization process, which mediate embryo adhesion or the attachment reaction.

  18. The changes in CD90 and CD105 expression in the testis and ovary of mice are reported.

  19. the altered immune activity of endoglin deficient macrophages could help to explain the higher rate of infectious diseases seen in HHT1 patients.

  20. These results demonstrate a requirement for endoglin in descendants of Pax3-expressing vascular cell precursors.

Endoglin (ENG) Protein Überblick

Protein Überblick

This gene encodes a homodimeric transmembrane protein which is a major glycoprotein of the vascular endothelium. This protein is a component of the transforming growth factor beta receptor complex and it binds TGFB1 and TGFB3 with high affinity. Mutations in this gene cause hereditary hemorrhagic telangiectasia, also known as Osler-Rendu-Weber syndrome 1, an autosomal dominant multisystemic vascular dysplasia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Genbezeichner und Symbole assoziert mit Endoglin Proteine (ENG)

  • endoglin (ENG)
  • endoglin (Eng)
  • AI528660 Protein
  • AI662476 Protein
  • CD105 Protein
  • DKFZp469D0419 Protein
  • END Protein
  • ENG Protein
  • HHT1 Protein
  • MGC137842 Protein
  • ORW1 Protein
  • S-endoglin Protein

Bezeichner auf Proteinebene für Endoglin Proteine (ENG)

endoglin (Osler-Rendu-Weber syndrome 1) , endoglin , endoglin-like , CD105 antigen , cell surface MJ7/18 antigen , transmembrane glycoprotein

GENE ID SPEZIES
609166 Canis lupus familiaris
615844 Bos taurus
741046 Pan troglodytes
771557 Gallus gallus
100173392 Pongo abelii
100226246 Taeniopygia guttata
100357448 Oryctolagus cuniculus
100387791 Callithrix jacchus
397096 Sus scrofa
2022 Homo sapiens
13805 Mus musculus
497010 Rattus norvegicus
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