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The protein encoded by DUSP2 is a member of the dual specificity protein phosphatase subfamily. Zusätzlich bieten wir Ihnen DUSP2 Antikörper (28) und und viele weitere Produktgruppen zu diesem Protein an.
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Authors report that hypoxia-mediated downregulation of the dual specificity phosphatase 2 (DUSP2) is critical for the accumulation of CSC in colorectal cancer.
Hypoxia inhibits DUSP2 expression in colon cancer, leading to up-regulation of IL-8 (zeige IL8 ELISA Kits), which facilitates angiogenesis and tumour metastasis.
Our data show that aberrant epigenetic inactivation of DUSP2 occurs in carcinogenesis and that CTCF (zeige CTCF ELISA Kits) is involved in the epigenetic regulation of DUSP2 expression.
Highly recurrent mutation of DUSP2 is associated with nodular lymphocyte predominant Hodgkin lymphoma.
Data show that hypoxia promotes lapatinib resistance in ERBB2 (zeige ERBB2 ELISA Kits)-positive breast cancer cells through activation of the MEK (zeige MAP2K1 ELISA Kits)-ERK (zeige EPHB2 ELISA Kits) pathway a HIF-1 (zeige HIF1A ELISA Kits)-dependent manner via regulation of dual-specificity phosphatase 2 (DUSP2).
DUSP2 is an important molecule in endometrial physiology and that hypoxia-inhibited DUSP2 expression is a critical factor for the development of endometriosis.
Dipyridamole reduced expression of PAC-1 (zeige ADCYAP1R1 ELISA Kits) and CD62p (zeige SELP ELISA Kits) in patients with malignant lymphoma.
DUSP2 is a key downstream regulator of HIF-1 (zeige HIF1A ELISA Kits)-mediated tumor progression and chemoresistance
During apoptosis, p53 (zeige TP53 ELISA Kits) activates transcription of PAC1 (zeige ADCYAP1R1 ELISA Kits) by binding to a palindromic site in the PAC1 (zeige ADCYAP1R1 ELISA Kits) promoter
relationships between the expression levels of CD61 (zeige ITGB3 ELISA Kits), CD63 (zeige CD63 ELISA Kits), and PAC-1 (zeige ADCYAP1R1 ELISA Kits) on the platelet surface and the incidences of acute rejection and tubular necrosis as well as the recovery of graft function after renal transplantation
Data indicate that dual specificity phosphatase 2 protein (DUSP2) is a true STAT3 (zeige STAT3 ELISA Kits) transcription factor phosphatase that modulates the development of TH17 cells in the autoimmune response and inflammation.
DUSP2 plays no role in regulating obesity-associated inflammation and only a minor role in controlling insulin (zeige INS ELISA Kits) sensitivity following high-fat diet in female, but not male, mice.
the expression of PAC1 in the thymus changes in reverse ratio with thymus index and in direct ratio with cell apoptosis and only low dose of PACAP had positive effects against the CPS-induced thymus atrophy.
Arg294 and Arg295 play an important role in PAC-1 (zeige ADCYAP1R1 ELISA Kits) catalytic activation induced by ERK2 (zeige MAPK1 ELISA Kits) binding
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1 and ERK2, is predominantly expressed in hematopoietic tissues, and is localized in the nucleus.
dual specificity protein phosphatase 2
, dual specificity protein phosphatase PAC-1
, dual-specificity phosphatase 2
, serine/threonine specific protein phosphatase