anti-Dishevelled, Dsh Homolog 3 (Drosophila) (DVL3) Antikörper

Xenopus laevis Dishevelled, Dsh Homolog 3 (Drosophila) (DVL3) Interaktionspartner

1. Different Dvl (zeige DVL2 Antikörper) proteins (Dvl1 (zeige DVL1 Antikörper), Dvl2 (zeige DVL2 Antikörper), Dvl3) and the composition of dishevelled (zeige DVL2 Antikörper)-beta-arrestin protein complexes contribute to the specific activation of individual branches of Wnt (zeige WNT2 Antikörper) signaling in Xenopus gastrulation.

2. Data show that maternal Dvl2 (zeige DVL2 Antikörper) and 3 are required for convergence extension movements downstream of the dorsally localized signaling pathway activated by Xnr3, but not downstream of the pathway activated by activin (zeige Actbeta Antikörper).

Mouse (Murine) Dishevelled, Dsh Homolog 3 (Drosophila) (DVL3) Interaktionspartner

1. Dvl-2 (zeige DVL2 Antikörper) and Dvl-3 have a widespread distribution in both the olfactory epithelium and olfactory bulb

2. Dvl3 is important for IPMK (zeige IPMK Antikörper) to access substrates and generate IP5, activating down-stream signaling.

3. Dishevelled (zeige DVL2 Antikörper)-KSRP (zeige KHSRP Antikörper) complex operates in Wnt (zeige WNT2 Antikörper) regulation of beta-catenin (zeige CTNNB1 Antikörper), functioning post-transcriptionally upon CTNNB1 (zeige CTNNB1 Antikörper) mRNA stability.

4. Dvl2 (zeige DVL2 Antikörper) and Dvl3 proteins were found to be localized to the apical side of the node cells, and their location was polarized to the posterior side of the cells before the posterior positioning of the basal body.

5. As embryos reach blastocyst stage, Dishevelled 2 (zeige DVL2 Antikörper) becomes increasingly associated with cell membrane in trophectoderm cells, while at E4.5, Dishevelled 3 is highly enriched in the cytoplasm of inner cell mass cells.

6. The expression of Dishevelleds in mammalian cells provide an estimate of the relative cellular abundance of each Dvl (zeige DVL1 Antikörper).

7. G alpha o (zeige GNAO1 Antikörper) mediates WNT (zeige WNT2 Antikörper)-JNK (zeige MAPK8 Antikörper) signaling through dishevelled 1 (zeige DVL1 Antikörper) and 3, RhoA (zeige RHOA Antikörper) family members, and MEKK 1 (zeige MAP2K1 Antikörper) and 4 in mammalian cells

8. Dvl1 (zeige DVL1 Antikörper), Dvl2 (zeige DVL2 Antikörper) and Dvl3 are functionally redundant in cardiac outflow tract, cochlea, and neural tube development.

Human Dishevelled, Dsh Homolog 3 (Drosophila) (DVL3) Interaktionspartner

1. Dvl3 is overexpressed in human HCCs (zeige HCCS Antikörper). The NP-Dvl3 is the more stable and active form of the protein and enhances HCC (zeige FAM126A Antikörper) stemness.

2. we found that Wnt3a (zeige WNT3A Antikörper) treatment rapidly induces hyperphosphorylation and stabilization of Dvl2 (zeige DVL2 Antikörper) and Dvl3. Our findings suggest a model of positive regulation of PKCzeta (zeige PRKCZ Antikörper)-mediated Dvl (zeige DVL2 Antikörper) signaling activity, to produce a strong and sustained response to Wnt3a (zeige WNT3A Antikörper) treatment by stabilizing Dvl (zeige DVL2 Antikörper) protein levels.

3. Studied and identified candidate biomarkers of biochemical recurrence (BCR (zeige BCR Antikörper)) of prostate adenocarcinoma by integrating reverse-phase protein array (RPPA) and mRNA datafrom The Cancer Genome Atlas (TCGA). Found DVL3 was expressed in patients with a higher risk of BCR (zeige BCR Antikörper). DVL3 may be a novel and easily applicable recurrence predictor of localised prostate adenocarcinoma.

4. two mutually exclusive functions of the DEP (zeige ZDHHC21 Antikörper) domain in Wnt (zeige WNT2 Antikörper) signal transduction - binding to Frizzled to recruit Dishevelled (zeige DVL2 Antikörper) to the receptor complex, is reported.

5. Genetic changes between MLH1 (zeige MLH1 Antikörper) and MSH2 (zeige MSH2 Antikörper) were significantly positively correlated (p = 0.032). We also noted a positive correlation between genetic changes of MSH2 (zeige MSH2 Antikörper) and DVL3 genes (p = 0.034).

6. Data show that dishevelled (zeige DVL2 Antikörper) proteins DVL1 (zeige DVL1 Antikörper), 2 and 3 were exclusively expressed in chronic lymphatic leukaemia (CLL) cells as compared to normal peripheral blood mononuclear cells (PBMCs).

7. Kif26b (zeige KIF26B Antikörper), together with Dvl3/Daam1 (zeige DAAM1 Antikörper), initiates cell polarity through the control of planar cell polarity-signaling pathway-dependent activation in endothelial cells.

8. DVL3 transcripts decreased in individuals with major depressive disorder

9. we demonstrate that normally ALFY (zeige WDFY3 Antikörper) attenuates the canonical Wnt (zeige WNT2 Antikörper) signaling pathway via autophagy-dependent removal specifically of aggregates of DVL3 and not of Dvl1 (zeige DVL1 Antikörper) or Dvl2 (zeige DVL2 Antikörper).

10. All variants in DVL3 result in a -1 frameshift, indicating that these highly specific alterations might be a common cause of dominant Robinow syndrome.