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Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Zusätzlich bieten wir Ihnen DPYSL3 Antikörper (85) und DPYSL3 Proteine (6) und viele weitere Produktgruppen zu diesem Protein an.
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Data indicate that CRMP4a and CRMP4b isoforms have opposite effects on cell proliferation, migration, and invasion in gastric cancer. CRMP4a expression was reduced in gastric carcinoma tissues and cell lines and seems to act as a tumor suppressor in gastric carcinoma. CRMP4b expression was higher in tumor tissue and cell lines.
DPYSL3 expression levels inversely correlated with those of VEGF and FAK. Down-regulation of DPYSL3 expression in HCC tissues may serve as a predictive biomarker for HCC after curative resection.
Expression status of DPYSL3 in gastric cancer tissues may represent a promising biomarker for the malignant behavior of GC.
DPYSL3 as pancreatic ductal adenocarcinoma-associated molecule that regulates cell adhesion and migration by stabilization of focal adhesion complex
structures provide further insight into the effects of medically relevant mutations of the DPYSL-3 gene encoding CRMP-4 and the putative enzymatic activities of CRMPs
High collapsin response mediator protein 4 expression is associated with liver metastasis in pancreatic cancer.
Downregulation of MYCN by small interfering RNA (siRNA) increased DPYSL3 levels, while upregulation of MYCN in non-MYCN NB cells decreased DPYSL3 levels.
study found the association between the rs147541241 variant and amyotrophic lateral scerosis was limited to the French population
Ulip1 was downregulated and HIF1a was upregulated in hypoxic neuroblastoma cells.
CRMP4 is a key physiological substrate of GSK3 in regulating chromosomal alignment and mitotic progression through its effect on spindle microtubules
Data show that two genes, LTB4DH and DPYSL3, were confirmed to be candidate genes for the predictor of a good immune response.
new function of CRMP4 as a metastasis-suppressor in lymph node metastasis of prostate cancer
Aberrant expression of dihydropyrimidinase related proteins-2,-3 and -4 in fetal Down syndrome brain.
HUlip was expressed in late fetal and early postnatal brains in the neurons of the brain stem, basal ganglia/thalamus, and dentate gyrus of the hippocampus. HUlip expression was easily detected in tumor cells undergoing neuronal differentiation. [Ulip]
GSK3 alters phosphorylation of CRMP-1, -2, and -4 isoforms
Knockdown of DPYSL3 promoted the metastatic ability of Lewis lung carcinoma cells.
findings identify CRMP4 as a novel negative regulator of osteoblast differentiation.
Crmp4 deletion promotes axonal growth and nociceptive recovery after spinal cord injury.
Results indicate that CRMP1 and CRMP4 regulate proper orientation of the basal dendrites of layer V neurons in the cerebral cortex during development.
CRMP4-deficient mice show reduced inflammation and suppressed dopaminergic neuronal death in a model of Parkinson's disease.
our data suggest that disruption of CRMP4 produces a temporary alteration in the thickness of the external of the olfactory bulb, which is constituted mainly of mitral cell apical dendrites, through the enhanced growth of these dendrites
These results suggest that deletion of CRMP4 is a unique therapeutic strategy that overcomes two obstacles to CNS repair after SCI.
CRMP4 inhibits prostate cancer cells growth in the nude mouse bone microenvironment.
This study identified a dual role for CRMP4 in regulating the actin and microtubule growth cone cytoskeleton.
In the human ortholog of Dpysl3, the association between the rs147541241 variant and amyotrophic lateral sclerosis was limited to the French population.
CRMP4 regulates the number of tyrosine hydroxylase immunoreactive neurons in the female anteroventral periventricular nucleus.
Results suggest that CRMP4 suppresses apical dendrite bifurcation of CA1 pyramidal neurons in the mouse hippocampus and that this is partly dependent on Sema3A signaling.
MAG-mediated axon protection against VNC is suppressed in CRMP4-/- DRG neurons.
Hypoxia-ischemia (HI)induces dephosphorylation of CRMPs (CRMP1, 2, and 5) in neonatal brain. Hypophosphorylated CRMPs might be implicated in the pathogenesis of HI-related neurological disorders.
Results demonstrate that collapsin response mediator proteins 2 and 4 function differentially in axon development and are required for axon guidance and growth in zebrafish retinal neurons.
phosphorylation of Dpysl2 and Dpysl3 by Cyclin-dependent kinase 5 and dual-specificity tyrosine-phosphorylated and regulated kinase 2 is required for correct positioning of CaP motor neurons in the zebrafish spinal cord
These results suggest that the phosphorylation of Dpysl2 and Dpysl3 by Cdk5 and DYRK2 is required for the proper positioning of Rohon-Beard neurons and neural crest cells during neurulation in zebrafish embryos.
Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity).
collapsin response mediator protein-4A
, collapsin response mediator protein-4B
, dihydropyrimidinase-related protein 3
, dihydropyrimidinase-like 3
, Dihydropyrimidinase-related protein 3
, hypothetical protein LOC494650
, Collapsin response mediator protein 4
, collapsin response mediator protein 4 long-like
, collapsin response mediator protein 4 long
, unc-33-like phosphoprotein 1
, collapsin response mediator protein 4
, TOAD-64/Ulip/CRMP protein 4b
, dihydropyrimidinase-related protein 3-A
, neural-specific protein 1