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DPPA3 encodes a protein that in mice may function as a maternal factor during the preimplantation stage of development. Zusätzlich bieten wir Ihnen DPPA3 Proteine (6) und viele weitere Produktgruppen zu diesem Protein an.
Showing 10 out of 18 products:
Human Polyclonal DPPA3 Primary Antibody für WB - ABIN2476602
Bowles, Teasdale, James, Koopman: Dppa3 is a marker of pluripotency and has a human homologue that is expressed in germ cell tumours. in Cytogenetic and genome research 2003
Human Polyclonal DPPA3 Primary Antibody für IF (p), IHC (p) - ABIN1713577
Wasielak, Więsak, Bogacka, Jalali, Bogacki: Zygote arrest 1, nucleoplasmin 2, and developmentally associated protein 3 mRNA profiles throughout porcine embryo development in vitro. in Theriogenology 2016
DPPA3 is a maternal factor (zeige ZAR1 Antikörper) important for correct epigenetic remodeling and normal embryonic development in cattle, indicating that the role of DPPA3 during early development is conserved between species.
Super-enhancers at the Nanog (zeige NANOG Antikörper) locus differentially regulate neighboring pluripotency-associated genes, in particular, DPPA3.
Data suggest enforced expression of Stella into normal cells induces not only global DNA demethylation but also neoplastic transformation and increases metastatic ability; these changes involve altered regulation of neoplastic gene expression.
Considering that impaired DNA methylation (zeige HELLS Antikörper) profiles are associated with various developmental or disease phenomena, Stella may be a powerful tool with which to study the biological effects of global DNA hypomethylation
a role for STELLA in facilitating germline and endodermal differentiation of human ES cells
human adult tissue-specific transcripts originate via retrotransposition of the pluripotent cell-specific gene, Dppa3
These results demonstrate that PGC7/Stella is indispensable for the maintenance of methylation involved in epigenetic reprogramming after fertilization.
In mice, a targeted mutation results in reduced female fertility and (zeige MTA2 Antikörper)may function as a mammalian maternal effect gene.
In mice, knockout experiments show this gene may be a maternal factor (zeige ZAR1 Antikörper) in cleavage stage embryogenesis.
PRDM1 (zeige PRDM1 Antikörper) and STELLA, while overlapping in putative primordial germ cells, also co-localize in several other tissues
The authors show that loss of maternal Stella results in widespread transcriptional mis (zeige AMH Antikörper)-regulation and a partial failure of maternal-to-zygotic transition.
This study shows repression of the Dppa3 Locus in the absence of MAD2L2 (zeige MAD2L2 Antikörper) embryonic stem cells.
In-depth transcriptome analysis of this mESC state reveals Dppa3 as a direct downstream target of Tbx3 (zeige TBX3 Antikörper).We show that Tbx3 (zeige TBX3 Antikörper), a downstream target of Wnt (zeige WNT2 Antikörper) signaling, fine tunes these divergent roles of Wnt (zeige WNT2 Antikörper) signaling in mESCs
Dppa3 has a critical role in generation of fully reprogrammed iPS (zeige SLC27A4 Antikörper) cells and maintenance of Dlk1 (zeige DLK1 Antikörper)-Dio3 (zeige DIO3 Antikörper) imprinting
Stella protects maternal chromosomes from aberrant epigenetic modifications to ensure early embryogenesis.
Chromocenter formation is impaired in Stella-null embryos.
we propose that Dppa3 is involved in the Tet-mediated active demethylation process during reprogramming of primordial germ cells.
PGC7 protects 5mC from Tet3 (zeige TET3 Antikörper)-mediated conversion to 5hmC by binding to maternal chromatin containing dimethylated histone H3 (zeige HIST3H3 Antikörper) lysine 9 (H3K9me2) in mice
These Dppa3-MCM strains offer valuable opportunities to explore gene function in both loss-of-function and gain-of-function experiments at a variety of time points during germ cell development.
This gene encodes a protein that in mice may function as a maternal factor during the preimplantation stage of development. In mice, this gene may play a role in transcriptional repression, cell division, and maintenance of cell pluripotentiality. In humans, related intronless loci are located on chromosomes 14 and X.
developmental pluripotency-associated protein 3
, stella-related protein
, developmental pluripotency associated 3
, compaction-associated protein 1
, primordial germ cell 7
, primordial germ cell protein 7