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DPPA3 Antikörper (C-Term)

DPPA3 Reaktivität: Maus WB Wirt: Kaninchen Polyclonal RB51138 unconjugated
Produktnummer ABIN6242289
  • Target Alle DPPA3 Antikörper anzeigen
    DPPA3 (Developmental Pluripotency Associated 3 (DPPA3))
    Bindungsspezifität
    • 7
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 134-170, C-Term
    Reaktivität
    • 20
    • 11
    • 1
    • 1
    Maus
    Wirt
    • 20
    • 1
    • 1
    Kaninchen
    Klonalität
    • 22
    Polyklonal
    Konjugat
    • 11
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser DPPA3 Antikörper ist unkonjugiert
    Applikation
    • 8
    • 8
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Aufreinigung
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This mouse Dppa3 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 134-170 amino acids from the C-terminal region of mouse Dppa3.
    Klon
    RB51138
    Isotyp
    Ig Fraction
    Top Product
    Discover our top product DPPA3 Primärantikörper
  • Applikationshinweise
    WB: 1:1000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Haltbarkeit
    6 months
  • Target
    DPPA3 (Developmental Pluripotency Associated 3 (DPPA3))
    Andere Bezeichnung
    Dppa3 (DPPA3 Produkte)
    Synonyme
    STELLA antikoerper, 2410075G02Rik antikoerper, PCG7 antikoerper, PGC7 antikoerper, Stella antikoerper, developmental pluripotency associated 3 antikoerper, developmental pluripotency-associated 3 antikoerper, DPPA3 antikoerper, Dppa3 antikoerper
    Hintergrund
    Primordial germ cell (PGCs)-specific protein involved in epigenetic chromatin reprogramming in the zygote following fertilization. In zygotes, DNA demethylation occurs selectively in the paternal pronucleus before the first cell division, while the adjacent maternal pronucleus and certain paternally-imprinted loci are protected from this process. Participates in protection of DNA methylation in the maternal pronucleus by preventing conversion of 5mC to 5hmC: specifically recognizes and binds histone H3 dimethylated at 'Lys-9' (H3K9me2) on maternal genome, and protects maternal genome from TET3-mediated conversion to 5hmC and subsequent DNA demethylation. Does not bind paternal chromatin, which is mainly packed into protamine and does not contain much H3K9me2 mark. Also protects imprinted loci that are marked with H3K9me2 in mature sperm from DNA demethylation in early embryogenesis. May be important for the totipotent/pluripotent states continuing through preimplantation development. Also involved in chromatin condensation in oocytogenesis.
    Molekulargewicht
    17670
    UniProt
    Q8QZY3
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