anti-Denticleless E3 Ubiquitin Protein Ligase Homolog (Drosophila) (DTL) Antikörper

Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis.

Alle Antikörper anzeigen Gen GeneID UniProt
Anti-Human DTL DTL 51514 Q9NZJ0
Anti-Ratte DTL DTL 305073  
Anti-Maus DTL DTL 76843 Q3TLR7
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Top anti-DTL Antikörper auf antikoerper-online.de

Showing 10 out of 54 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert WB WB Suggested Anti-DTL Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:62500  Positive Control:  721_B cell lysate DTL is supported by BioGPS gene expression data to be expressed in 721_B 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Human Kaninchen Unkonjugiert ICC, IF, IHC, IHC (p), IP, WB Western Blot and Immunoprecipitation: DTL/CDT2 Antibody [ABIN251524] - Detection of Human DTL/CDT2 by Western Blot and Immunoprecipitation. Samples: Whole cell lysate from HeLa (5, 15 and 50 mcg for WB, 1 mg for IP, 20% of IP loaded) and 293T (T, 50 mcg) cells. Antibodies: Affinity purified rabbit anti- DTL/CDT2 antibody ABIN251524 used for WB at 0.04 mcg/ml (A) and 1 mcg/ml (B) and used for IP at 3 mcg/mg lysate (B). DTL/CDT2 was also immunoprecipitated by other rabbit anti- DTL/CDT2 antibodies and ABIN251523, which recognize upstream epitopes. Detection: Chemiluminescence with exposure times of 30 seconds (A) and 10 seconds (B). Immunohistochemistry-Paraffin: CDT2 Antibody [ABIN2515240] - Human colon carcinoma (left) and mouse hybridoma tumor (right). Antibody used at a dilution of 1:1,000. 0.1 mL Anmelden zum Anzeigen 7 bis 9 Tage
$556.31
Details
Human Kaninchen Unkonjugiert FACS, WB DTL Antibody (Center) (ABIN654926) flow cytometric analysis of Hela cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$324.50
Details
Human Kaninchen Unkonjugiert ICC, IF, IHC, IHC (p), WB Immunofluorescence: CDT2 Antibody [NBP1-85283] - Staining of human cell line U-251MG shows positivity in nucleus but not nucleoli. Immunohistochemistry-Paraffin: CDT2 Antibody [NBP1-85283] - Staining of human bone marrow shows strong nuclear positivity in bone marrow poietic cells. 0.1 mL Anmelden zum Anzeigen 10 bis 13 Tage
$491.63
Details
Human Kaninchen Unkonjugiert EIA, FACS, WB Flow cytometric analysis of Hela cells using CDT2 / DTL Antibody  (right histogram) compared to a negative control cell (left histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. Western blot analysis of CDT2 / DTL Antibody  in mouse spleen tissue lysates (35ug/lane). This demonstrates the DTL antibody detected the DTL protein (arrow). 0.4 mL Anmelden zum Anzeigen 6 bis 8 Tage
$390.50
Details
Fledermaus Kaninchen Unkonjugiert WB 50 μg Anmelden zum Anzeigen 7 bis 9 Tage
$551.83
Details
Human Kaninchen Unkonjugiert WB Western Blot: CDT2 Antibody [NBP1-54644] - 721_B cell lysate, concentration 0.2-1 ug/ml. 100 μL Anmelden zum Anzeigen 8 bis 11 Tage
$485.88
Details
Human Kaninchen Unkonjugiert FACS, WB Western blot analysis in mouse spleen tissue lysates (35ug/lane). Flow cytometric analysis of Hela cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. 400 μL Anmelden zum Anzeigen 2 bis 3 Tage
$515.63
Details
Human Kaninchen Unkonjugiert WB   100 μL Anmelden zum Anzeigen 7 bis 9 Tage
$383.17
Details
Human Kaninchen Unkonjugiert WB   200 μL Anmelden zum Anzeigen 13 bis 14 Tage
$487.50
Details

Am meisten referenzierte anti-DTL Antikörper

  1. Human Polyclonal DTL Primary Antibody für ICC, IF - ABIN251524 : Jørgensen, Eskildsen, Fugger, Hansen, Larsen, Kousholt, Syljuåsen, Trelle, Jensen, Helin, Sørensen: SET8 is degraded via PCNA-coupled CRL4(CDT2) ubiquitylation in S phase and after UV irradiation. in The Journal of cell biology 2011 (PubMed)
    Show all 4 Pubmed References

  2. Human Polyclonal DTL Primary Antibody für ICC, IF - ABIN4297129 : Karaayvaz, Pal, Song, Zhang, Georgakopoulos, Mehmood, Burke, Shroyer, Ju: Prognostic significance of miR-215 in colon cancer. in Clinical colorectal cancer 2011 (PubMed)

  3. Human Polyclonal DTL Primary Antibody für EIA, FACS - ABIN951451 : Centore, Havens, Manning, Li, Flynn, Tse, Jin, Dyson, Walter, Zou: CRL4(Cdt2)-mediated destruction of the histone methyltransferase Set8 prevents premature chromatin compaction in S phase. in Molecular cell 2010 (PubMed)
    Show all 3 Pubmed References

Weitere Antikörper gegen DTL Interaktionspartner

Human Denticleless E3 Ubiquitin Protein Ligase Homolog (Drosophila) (DTL) Interaktionspartner

  1. Findings suggest that DTL (zeige TNFSF13B Antikörper) overexpression plays a crucial role in tumor cell proliferation in gastric carcinoma.

  2. CDT2 mediated XPG (zeige ERCC5 Antikörper) elimination from DNA damage sites clears the chromatin space needed for repair.

  3. CDT2 likely is a non-oncogene (zeige RAB1A Antikörper) to which transformed cells become addicted because of their enhanced cellular stress, such as replicative stress and DNA damage.

  4. These findings reveal C/EBPalpha (zeige CEBPA Antikörper) regulates G1/S cell cycle arrest in response to DNA damage via the control of CRL4(Cdt2) mediated degradation of p21 (zeige CDKN1A Antikörper).

  5. CDK1 activity blocks CRL4CDT2 by preventing chromatin recruitment of the substrate receptor, CDT2.

  6. while interaction with PCNA (zeige PCNA Antikörper) was important for targeting p21 (zeige CDKN1A Antikörper) to the CRL4Cdt2 ligase re-localized to MVM replication centers

  7. CRL4(Cdt2)-dependent degradation of TDG (zeige TDG Antikörper) occurs in S phase because of the requirement for TDG (zeige TDG Antikörper) to interact with chromatin-loaded PCNA (zeige PCNA Antikörper), and this degradation is important for preventing toxicity from excess TDG (zeige TDG Antikörper).

  8. Data shows that phosphorylation of Cdt2 at T464 is important fot its interaction with Cdt2.

  9. TGF-beta signaling promotes exit from the cell cycle and cellular migration through cullin cross-regulation: SCF-FBXO11 turns off CRL4-Cdt2.

  10. ubiquitination of p12 through CRL4(Cdt2) and subsequent degradation form one mechanism by which a cell responds to DNA damage to inhibit fork progression.

Mouse (Murine) Denticleless E3 Ubiquitin Protein Ligase Homolog (Drosophila) (DTL) Interaktionspartner

  1. Maternal DCAF2 protein is crucial for prevention of DNA re-replication in the first and unique mitotic cell cycle of the zygote.

  2. while interaction with PCNA (zeige PCNA Antikörper) was important for targeting p21 (zeige D4S234E Antikörper) to the CRL4Cdt2 ligase re-localized to MVM replication centers

  3. L2dtl gene expression is essential for very early mouse embryonic development

DTL Antigen-Profil

Protein Überblick

Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1 and CDKN1A/p21(CIP1). CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication. CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing. Most substrates require their interaction with PCNA for PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis (By similarity).

Genbezeichner und Symbole assoziert mit DTL

  • denticleless E3 ubiquitin protein ligase homolog (DTL) Antikörper
  • denticleless E3 ubiquitin protein ligase homolog (Dtl) Antikörper
  • denticleless E3 ubiquitin protein ligase (Dtl) Antikörper
  • 2810047L02Rik Antikörper
  • 5730564G15Rik Antikörper
  • CDT2 Antikörper
  • DCAF2 Antikörper
  • L2DTL Antikörper
  • Ramp Antikörper
  • RGD1310439 Antikörper

Bezeichner auf Proteinebene für DTL

DDB1 and CUL4 associated factor 2 , DDB1- and CUL4-associated factor 2 , RA regulated nuclear matrix associated protein , RA-regulated nuclear matrix-associated protein , denticleless homolog , denticleless protein homolog , lethal(2) denticleless protein homolog , retinoic acid-regulated nuclear matrix-associated protein , Meth A ramp , meth A retinoic acid-regulated nuclear matrix-associated protein , retinoic-acid regulated nuclear matrix-associated protein

GENE ID SPEZIES
51514 Homo sapiens
490279 Canis lupus familiaris
539953 Bos taurus
305073 Rattus norvegicus
421373 Gallus gallus
76843 Mus musculus
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