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Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis.
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Human Polyclonal DTL Primary Antibody für ICC, IF - ABIN251524
Jørgensen, Eskildsen, Fugger, Hansen, Larsen, Kousholt, Syljuåsen, Trelle, Jensen, Helin, Sørensen: SET8 is degraded via PCNA-coupled CRL4(CDT2) ubiquitylation in S phase and after UV irradiation. in The Journal of cell biology 2011
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Human Polyclonal DTL Primary Antibody für ICC, IF - ABIN4297129
Karaayvaz, Pal, Song, Zhang, Georgakopoulos, Mehmood, Burke, Shroyer, Ju: Prognostic significance of miR-215 in colon cancer. in Clinical colorectal cancer 2011
Human Polyclonal DTL Primary Antibody für EIA, FACS - ABIN951451
Centore, Havens, Manning, Li, Flynn, Tse, Jin, Dyson, Walter, Zou: CRL4(Cdt2)-mediated destruction of the histone methyltransferase Set8 prevents premature chromatin compaction in S phase. in Molecular cell 2010
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Findings suggest that DTL (zeige TNFSF13B Antikörper) overexpression plays a crucial role in tumor cell proliferation in gastric carcinoma.
CDT2 mediated XPG (zeige ERCC5 Antikörper) elimination from DNA damage sites clears the chromatin space needed for repair.
CDT2 likely is a non-oncogene (zeige RAB1A Antikörper) to which transformed cells become addicted because of their enhanced cellular stress, such as replicative stress and DNA damage.
These findings reveal C/EBPalpha (zeige CEBPA Antikörper) regulates G1/S cell cycle arrest in response to DNA damage via the control of CRL4(Cdt2) mediated degradation of p21 (zeige CDKN1A Antikörper).
CDK1 activity blocks CRL4CDT2 by preventing chromatin recruitment of the substrate receptor, CDT2.
while interaction with PCNA (zeige PCNA Antikörper) was important for targeting p21 (zeige CDKN1A Antikörper) to the CRL4Cdt2 ligase re-localized to MVM replication centers
CRL4(Cdt2)-dependent degradation of TDG (zeige TDG Antikörper) occurs in S phase because of the requirement for TDG (zeige TDG Antikörper) to interact with chromatin-loaded PCNA (zeige PCNA Antikörper), and this degradation is important for preventing toxicity from excess TDG (zeige TDG Antikörper).
Data shows that phosphorylation of Cdt2 at T464 is important fot its interaction with Cdt2.
TGF-beta signaling promotes exit from the cell cycle and cellular migration through cullin cross-regulation: SCF-FBXO11 turns off CRL4-Cdt2.
ubiquitination of p12 through CRL4(Cdt2) and subsequent degradation form one mechanism by which a cell responds to DNA damage to inhibit fork progression.
Maternal DCAF2 protein is crucial for prevention of DNA re-replication in the first and unique mitotic cell cycle of the zygote.
while interaction with PCNA (zeige PCNA Antikörper) was important for targeting p21 (zeige D4S234E Antikörper) to the CRL4Cdt2 ligase re-localized to MVM replication centers
L2dtl gene expression is essential for very early mouse embryonic development
Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1 and CDKN1A/p21(CIP1). CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication. CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing. Most substrates require their interaction with PCNA for PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis (By similarity).
DDB1 and CUL4 associated factor 2
, DDB1- and CUL4-associated factor 2
, RA regulated nuclear matrix associated protein
, RA-regulated nuclear matrix-associated protein
, denticleless homolog
, denticleless protein homolog
, lethal(2) denticleless protein homolog
, retinoic acid-regulated nuclear matrix-associated protein
, Meth A ramp
, meth A retinoic acid-regulated nuclear matrix-associated protein
, retinoic-acid regulated nuclear matrix-associated protein