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anti-DTL Antikörper

Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis.

40 Treffer:

anti-DTL Antikörper (Denticleless E3 Ubiquitin Protein Ligase Homolog (Drosophila)) (C-Term) Primary Antibody

DTL Reaktivität: Human, Maus FACS, IF, IP, WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN2451940
$500.00
Zzgl. Versandkosten $45.00
100 μL
local_shipping Lieferung nach: Vereinigte Staaten von Amerika
Lieferung in 9 bis 11 Werktagen

anti-DTL Antikörper (Denticleless E3 Ubiquitin Protein Ligase Homolog (Drosophila)) (AA 229-256) Primary Antibody

DTL Reaktivität: Human, Maus EIA, FACS, WB Wirt: Kaninchen Polyclonal unconjugated
Pubmed 1
Produktnummer ABIN951451
$539.00
Zzgl. Versandkosten $45.00
0.4 mL
local_shipping Lieferung nach: Vereinigte Staaten von Amerika
Lieferung in 6 bis 8 Werktagen

anti-DTL Antikörper (Denticleless E3 Ubiquitin Protein Ligase Homolog (Drosophila)) (AA 1-730) Primary Antibody

DTL Reaktivität: Human IF, WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN949333
$585.71
Zzgl. Versandkosten $45.00
100 μg
local_shipping Lieferung nach: Vereinigte Staaten von Amerika
Lieferung in 11 bis 12 Werktagen

anti-DTL Antikörper (Denticleless E3 Ubiquitin Protein Ligase Homolog (Drosophila)) Primary Antibody

DTL Reaktivität: Human, Maus ELISA, WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6390479
$367.82
Zzgl. Versandkosten $45.00
100 μL (More quantities available)
local_shipping Lieferung nach: Vereinigte Staaten von Amerika
Lieferung in 11 bis 13 Werktagen

anti-DTL Antikörper (Denticleless E3 Ubiquitin Protein Ligase Homolog (Drosophila)) (N-Term) Primary Antibody

DTL Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Meerschweinchen, Pferd, Kaninchen WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN2782560
$389.00
Zzgl. Versandkosten $45.00
100 μL
local_shipping Lieferung nach: Vereinigte Staaten von Amerika
Lieferung in 2 bis 3 Werktagen

anti-DTL Antikörper (Denticleless E3 Ubiquitin Protein Ligase Homolog (Drosophila)) (AA 229-256) Primary Antibody

DTL Reaktivität: Human, Maus FACS, WB Wirt: Kaninchen Polyclonal RB24420 unconjugated
Produktnummer ABIN654926
$412.50
Zzgl. Versandkosten $45.00
400 μL (More quantities available)
local_shipping Lieferung nach: Vereinigte Staaten von Amerika
Lieferung in 10 bis 11 Werktagen

anti-DTL Antikörper (Denticleless E3 Ubiquitin Protein Ligase Homolog (Drosophila)) (AA 182-231) Primary Antibody

DTL Reaktivität: Human, Maus, Ratte, Fledermaus, Rind (Kuh), Hund, Meerschweinchen, Pferd, Affe, Schwein, Kaninchen WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6738232
$597.30
Zzgl. Versandkosten $45.00
100 μL
local_shipping Lieferung nach: Vereinigte Staaten von Amerika
Lieferung in 11 bis 14 Werktagen

anti-DTL Antikörper (Denticleless E3 Ubiquitin Protein Ligase Homolog (Drosophila)) (N-Term) Primary Antibody

DTL Reaktivität: Human WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN2442043
$318.55
Zzgl. Versandkosten $45.00
100 μL
local_shipping Lieferung nach: Vereinigte Staaten von Amerika
Lieferung in 2 bis 3 Werktagen

anti-DTL Antikörper (Denticleless E3 Ubiquitin Protein Ligase Homolog (Drosophila)) Primary Antibody

DTL Reaktivität: Human, Maus, Ratte IF (p), IHC (p), WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN873173
$339.90
Zzgl. Versandkosten $45.00
100 μL
local_shipping Lieferung nach: Vereinigte Staaten von Amerika
Lieferung in 4 bis 6 Werktagen

anti-DTL Antikörper (Denticleless E3 Ubiquitin Protein Ligase Homolog (Drosophila)) Primary Antibody

DTL Reaktivität: Human, Maus, Ratte ELISA, IP, WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN5705388
$380.00
Zzgl. Versandkosten $45.00
100 μg
local_shipping Lieferung nach: Vereinigte Staaten von Amerika
Lieferung in 10 bis 13 Werktagen
  • Typ Primary
    • Primary
  • Target Denticleless E3 Ubiquitin Protein Ligase Homolog (Drosophila) (DTL)
    • Denticleless E3 Ubiquitin Protein Ligase Homolog (Drosophila) (DTL)
    • Histone 3 (H3)
    • Tumor Protein P53 (TP53)
    • Epidermal Growth Factor Receptor (EGFR)
    • Mast/stem Cell Growth Factor Receptor (KIT)
    • Protein tyrosine Phosphatase, Receptor Type, C (PTPRC)
    • tau Protein
    • CD4 Molecule (CD4)
    • Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2)
    • Tumor Necrosis Factor alpha (TNF)
    • V-Akt Murine Thymoma Viral Oncogene Homolog 1 (AKT1)
    • Nuclear Factor-KB P65 (NFkBP65)
    • Interferon gamma (IFNG)
    • Estrogen Receptor 1 (ESR1)
    • BCL2-Associated Agonist of Cell Death (BAD)
    • Albumin (ALB)
    • B-Cell CLL/lymphoma 2 (BCL2)
    • V-Raf-1 Murine Leukemia Viral Oncogene Homolog 1 (RAF1)
    • Tuberous Sclerosis 2 (TSC2)
    • CD19 Molecule (CD19)
    • Platelet/endothelial Cell Adhesion Molecule (PECAM1)
    • CD8a Molecule (CD8A)
    • Hemagglutinin (HA)
    • CD3e Molecule, epsilon (CD3-TCR Complex) (CD3E)
    • Integrin alpha M (ITGAM)
    • CD8
    • CD44
    • Histone H4
    • Jun Proto-Oncogene (JUN)
    • Myc Proto-Oncogene protein (MYC)
    • Interleukin 6 (IL6)
    • Epithelial Cell Adhesion Molecule (EPCAM)
    • Ribosomal Protein S6 Kinase, 70kDa, Polypeptide 1 (RPS6KB1)
    • Catenin, beta
    • Interleukin 2 Receptor, alpha (IL2RA)
    • Mucin 1, Cell Surface Associated (MUC1)
    • PTK2 Protein tyrosine Kinase 2 (PTK2)
    • Vimentin (VIM)
    • CD5 Molecule (CD5)
    • Membrane-Spanning 4-Domains, Subfamily A, Member 1 (MS4A1)
    • Amyloid beta (A4) Precursor Protein (APP)
    • CD3
    • Insulin Receptor Substrate 1 (IRS1)
    • C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1)
    • Glial Fibrillary Acidic Protein (GFAP)
    • CD34
    • Interleukin 2 (IL2)
    • Kinase insert Domain Receptor (A Type III Receptor tyrosine Kinase) (KDR)
    • Keratin 18 (KRT18)
    • CD14
    • Synuclein, alpha (SNCA)
  • Anwendung
    • Western Blotting (WB)
    • ELISA
    • Flow Cytometry (FACS)
    • Immunohistochemistry (IHC)
    • Immunofluorescence (IF)
    • Immunoprecipitation (IP)
    • Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    • Enzyme Immunoassay (EIA)
    • Immunofluorescence (Paraffin-embedded Sections) (IF (p))
  • Reaktivität
    • Human
    • Maus
    • Ratte
    • Rind (Kuh)
    • Hund
    • Meerschweinchen
    • Pferd
    • Kaninchen
    • Fledermaus
    • Affe
    • Schwein
  • In Publikationen zitiert
  • Abbildungen verfügbar
  • Wirt
    • Kaninchen
    • Huhn
  • Klonalität
    • Polyclonal
  • Klon
    • RB24420
  • Bindungsspezifität
    • AA 229-256
    • Center
    • Internal Region
    • AA 393-550
    • AA 1-730
    • C-Term
    • N-Term
    • AA 1-196
    • AA 182-231
    • AA 375-425
    • AA 680-730
    • Middle Region
  • Konjugat
    • Unkonjugiert
    • Biotin
    • FITC
    • HRP
    • APC
    • Alkaline Phosphatase (AP)
    • PE
    • Alexa Fluor 488
    • Alexa Fluor 555
    • Alexa Fluor 594
    • Alexa Fluor 647
    • Alexa Fluor 680
    • Alexa Fluor 750
  • Isotyp
    • IgG
    • Ig Fraction
  • Format
    • Liquid
    • Lyophilized

DTL Antigen-Profil

Protein Überblick

Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1 and CDKN1A/p21(CIP1). CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication. CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing. Most substrates require their interaction with PCNA for PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis (By similarity).

Genbezeichner und Symbole assoziert mit DTL

  • denticleless E3 ubiquitin protein ligase homolog (DTL) Antikörper
  • denticleless E3 ubiquitin protein ligase (Dtl) Antikörper
  • denticleless E3 ubiquitin protein ligase homolog (Dtl) Antikörper
  • denticleless E3 ubiquitin protein ligase homolog S homeolog (dtl.S) Antikörper
  • denticleless E3 ubiquitin protein ligase homolog (Drosophila) (dtl) Antikörper
  • 2810047L02Rik Antikörper
  • 5730564G15Rik Antikörper
  • cb151 Antikörper
  • cdt2 Antikörper
  • cdt2-a Antikörper
  • chunp6871 Antikörper
  • dcaf2 Antikörper
  • l2dtl Antikörper
  • ramp Antikörper
  • RGD1310439 Antikörper
  • wu:fb54b02 Antikörper

Bezeichner auf Proteinebene für DTL

DDB1 and CUL4 associated factor 2 , DDB1- and CUL4-associated factor 2 , RA regulated nuclear matrix associated protein , RA-regulated nuclear matrix-associated protein , denticleless homolog , denticleless protein homolog , lethal(2) denticleless protein homolog , retinoic acid-regulated nuclear matrix-associated protein , Meth A ramp , meth A retinoic acid-regulated nuclear matrix-associated protein , retinoic-acid regulated nuclear matrix-associated protein , denticleless protein homolog A

GENE ID SPEZIES
51514 Homo sapiens
76843 Mus musculus
305073 Rattus norvegicus
490279 Canis lupus familiaris
421373 Gallus gallus
735103 Xenopus laevis
539953 Bos taurus
100723475 Cavia porcellus
192314 Danio rerio

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