anti-Cytochrome P450, Family 2, Subfamily E, Polypeptide 1 (CYP2E1) Antikörper

Rabbit Cytochrome P450, Family 2, Subfamily E, Polypeptide 1 (CYP2E1) Interaktionspartner

1. The localization of CYP1A2, CYP2B4 and CYP2E1 within the ER was determined by partial membrane solubilization with Brij 98

2. this study indicates that the gender difference in cytochrome P4503A activity may be one of the important factors for the development of steroid-induced osteonecrosis, possibly due to the effects of oestradiol.

Guinea Pig Cytochrome P450, Family 2, Subfamily E, Polypeptide 1 (CYP2E1) Interaktionspartner

1. Cytochrome P450 2E1 takes part in the pathogenesis of experimental metabolic syndrome in guinea pigs.

Human Cytochrome P450, Family 2, Subfamily E, Polypeptide 1 (CYP2E1) Interaktionspartner

1. Data suggest an important role of CYP2E1 in the generation of epsilondA, in the fibrotic progression of alcoholic liver disease, and thus in alcohol-mediated hepatocarcinogenesis.

2. This first study of polymorphisms in Colombian patients diagnosed with cirrhosis and/or HCC showed genotypes ADH1B*1/1, ADH1C*1/1 and CYP2E1*C/C as the most frequent

3. Data show that hepatofibrotic patients with higher cytochrome P-450 (CYP2E1) activity more readily develop hepatocellular carcinoma (HCC) and that higher CYP2E1 activity is a risk factor for the development of hepatocarcinogenesis from hepatofibrosis.

4. A polymorphism of CYP2E1 may be directly associated with the development of Isoniazid hepatotoxicity.

5. We evaluated genetic variability of single nucleotide polymorphisms (SNPs) situated in the CYP2E1 gene promoter in alcoholics in central Brazil. Our results showed that the allelic frequencies were markedly different among ethnicities and have contributed to the knowledge regarding the distribution among ethnic groups, being associated to alcohol consumption worldwide.

6. no genetic association between CYP2E1 and alcohol dependence in Han Taiwanese either by single allele tests or haplotype-based analyses

7. Study provides evidence for an association between CYP2E1 gene polymorphisms and bladder cancer progression, and suggests that CYP2E1 gene polymorphisms might be a protective factor against bladder cancer in Asian people

8. The results showed that no difference in chromosome damage was found among the three genotypes of CYP2E1.

9. Report CYP2E1 inhibitory capacity of diallyl sulfide analogs and roles in reducing ethanol- and acetaminophen-induced toxicity in hepatocytes.

10. CYP2E1 role in actiavation of the polychlorinated biphenyls mutagens

11. Case-control study found a significant difference was observed between large artery atherosclerotic ischemic stroke patients and controls with respect to the CYP2E1*5B genotype and allele distribution. NQO1*2 polymorphism genotype distribution was significantly different between patients and controls and heterozygote *1*2 genotype was found to be a protective factor against large artery atherosclerotic ischemic stroke.

12. The observations of the present study give rise to useful information on CYP2E1 polymorphisms in Chinese Uygur individuals.

13. results provide new information regarding CYP2E1 genetic polymorphisms in Chinese Tibetan population. These findings in this study would be value for further study in assessing the susceptibility of different populations to diseases related to CYP2E1 polymorphisms and determining whether it is necessary to design different therapeutics and toxicological protocols to reduce the risk of population, including pharmacogenetic

14. Clomethiazole is a direct inhibitor of human CYP2E1 when coincubated with the probe substrate chlorzoxazone.

15. Methodology to assay CYP2E1 mixed function oxidase catalytic activity and its induction.

16. Polymorphisms in the promoter region of the CYP2E1 gene were associated with DNA damage in alcoholics.

17. We identified an exposure-associated differentially methylated region (DMR) spanning nine sequential CpG sites in the promoter-regulatory region of the cytochrome P450 2E1 gene (CYP2E1) on chromosome 10 (corrected P=2.98 x 10(-5)). Elevated DNA methylation across this region was also associated with deprivation-related clinical markers of impaired social cognition.

18. A significant increase in the risk of non-small cell lung cancer was observed for the following combinations: TP53 codon72 variant with GSTM1 null (OR 2.22, 95 % CI 1.23-4.04; p=0.009), GSTT1 null (OR 2.98, 95 % CI 1.49-5.94; p=0.002), and GSTP1 (Ala114Val) variant genotypes (OR 3.38, 95 % CI 1.54-7.41; p=0.002).

19. Studied the possible relationship between cytochrome P450, family 2, subfamily E and polypeptide 1 (CYP2E1) polymorphisms with Kawasaki disease (KD). Found the KD patients with a CYP2E1 CC genotype of rs915906 demonstrated a greater proportion of coronary artery lesions (CALs) formation.

20. The results suggest that changes in coumarin pharmacokinetics and CYP2E1 subcellular distribution contribute to resistance to coumarin-induced hepatic necrosis, while cytotoxicity of metabolic conjugates shown in vitro may contribute to bile duct damage upon repeated coumarin administration.

Mouse (Murine) Cytochrome P450, Family 2, Subfamily E, Polypeptide 1 (CYP2E1) Interaktionspartner

1. Cyp2e1 mRNA expression was increased by MRSA in the kidney of mice.

2. The ablation of Rdh13 gene decreased the expression levels of thyroid hormone-inducible nuclear protein 14 (Spot14) and cytochrome P450 (Cyp2e1) in the liver, especially after CCl(4) treatment for 48 h.

3. results demonstrate that 2,3,4',5-tetrahydroxystilbene-2-O-beta-D-glucoside enhances hepatic expression of CYP3A4, CYP2E1 and CYP1A2, and thus exacerbates the hepatotoxicity induced by acetaminophen in mice.

4. These findings support the notion that a regulatory cascade comprising PP2A-B56alpha, beta-catenin, and Cyp2e1 is involved in benzene-induced hematotoxicity, providing critical insight into the role of PP2A in responses to the environmental chemicals.

5. Ethanol-mediated up-regulation of CYP2E1 via SUMOylation enhancing its protein stability and activity and may have important implications in alcoholic liver disease.

6. these results demonstrate that CYP2E1 is important in fast food-mediated liver fibrosis by promoting nitroxidative and endoplasmic reticulum stress, endotoxemia, inflammation, insulin resistance, and low energy expenditure

7. The significant increase of Cyp2e1 transcript level and protein expression was found in the liver and hippocampi during spontaneous recurrent seizures in mice.

8. CYP2E1-induced oxidative stress may be responsible for ethanol-induced suppression of Akt phosphorylation and pharmacological modulation of Akt in liver may be an effective strategy for the treatment of ethanol-induced fatty liver.

9. BI-1 protects against obesity-induced hepatic insulin resistance by regulating CYP2E1 activity and reactive oxygen species production.

10. Baicalin inhibited ethanol-induced expression of reactive oxygen species (ROS) generating enzymes NOX2, p67phox, xanthine oxidase, and iNOS in addition to CYP2E1 activities.

11. Methodology to assay CYP2E1 mixed function oxidase catalytic activity and its induction/

12. we show that TRPV4 is activated both by damage associated molecular pattern HMGB1 and collagen in diseased Kupffer cells that in turn activate the endothelial NOS (NOS3) to release nitric oxide (NO). The diffusible NO acts in a paracrine fashion in neighboring hepatocytes to deactivate the redox toxicity induced by CYP2E1

13. Data, including data from studies in knockout mice, suggest that the oxidative metabolism of 1,2-dichloropropane, a carcinogenic solvent/insecticide, is exclusively catalyzed by Cyp2e1; this biotransformation step is indispensable for manifestation of hepatotoxic effect of the solvent.

14. Taken together, these results suggested that 1,2-dichloroethane (1,2-DCE) could enhance CYP2E1 protein expression and enzymatic activity, which could cause oxidative damage in liver, serving as an important mechanism underlying 1,2-DCE-induced liver damage

15. CYP2E1 is important in causing aging-dependent hepatic steatosis, apoptosis and fibrosis possibly through increasing nitroxidative stress.

16. Our results support a significant role for CYP2E1 as a novel 4-Aminobiphenyl N-oxidizing enzyme in adult mice

17. Schisandrol B protects against APAP-induced liver injury, potentially through inhibition of CYP2E1/3A11-mediated APAP bioactivation and regulation of the p53, p21, CCND1, PCNA, and BCL-2 to promote liver regeneration.

18. Studied hepatic stellate cell cytoglobin involvement in acetaminophen induced hepatotoxicity through the regulation of CYP2E1.

19. Data suggest that expression of Cyp2e1 in adipose tissue can be regulated by dietary factors; here, expression of Cyp2e1 in white adipose tissue is down-regulated in obesity caused by high-fat diet.

20. The Cyp2e1-null mice displayed a susceptibility to lung toxicity of styrene similar to that of the wild-type animals; however, Cyp2f2-null mice were resistant to styrene-induced pulmonary toxicity.

Pig (Porcine) Cytochrome P450, Family 2, Subfamily E, Polypeptide 1 (CYP2E1) Interaktionspartner

1. this study summarises the current knowledge about the regulation of porcine CYP2A19 and CYP2E1 by environmental, biological and dietary factors. [Review]

2. A highly significant association was found between variation in skatole levels and SNPs within the CYP2E1 gene on chromosome 14.

3. The relationship between a single nucleotide polymorphism of CYP2E1 and boar taint in pork from Belgian swine is reported.

4. the G --> A substitute might be at least partially responsible for a high level of skatole in pigs