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CYP2C8 encodes a member of the cytochrome P450 superfamily of enzymes. Zusätzlich bieten wir Ihnen CYP2C8 Proteine (3) und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal CYP2C8 Primary Antibody für ELISA, WB - ABIN4302095
Leskelä, Jara, Leandro-García, Martínez, García-Donas, Hernando, Hurtado, Vicario, Montero-Conde, Landa, López-Jiménez, Cascón, Milne, Robledo, Rodríguez-Antona: Polymorphisms in cytochromes P450 2C8 and 3A5 are associated with paclitaxel neurotoxicity. in The pharmacogenomics journal 2011
Clopidogrel increases the exposure to pioglitazone by inhibiting its CYP2C8-mediated biotransformation.
Using an integrated pathway-based approach, we identified polymorphisms in ABCC6 (zeige ABCC6 Antikörper), ABCB1 (zeige ABCB1 Antikörper) and CYP2C8 associated with overall survival. These associations were replicated in a large independent cohort, highlighting the importance of pharmacokinetic genes as prognostic markers in Ewing sarcoma
review summarizes glucuronides as CYP2C8 ligands and the active-site structural features of CYP2C8 that allow potential binding to glucuronides
Preliminary results demonstrate SNPs in CYP2C8 represent potential genetic markers of coronary heart disease susceptibility.
Inhibition of CYP2C8 activity adds to the protective effects of omega-3 LCPUFA on pathological retinal neovascularization and choroidal neovascularization.
CYP2C8*3 carriers had an increased risk of peripheral neuropathy
CYP2C8 Variants are associated with Ischemic Stroke.
This review focuses on recent findings of in vitro studies on drug metabolizing activity of 3 highly polymorphic CYP2C (zeige CYP2C19 Antikörper) members: CYP2C8, CYP2C9 (zeige CYP2C9 Antikörper), and CYP2C19 (zeige CYP2C19 Antikörper).
CYP2C8*3 is a gain-of-function polymorphism for imatinib N-demethylation, which appears to be mainly mediated by CYP2C8 and not CYP3A4 (zeige CYP3A4 Antikörper) in vitro in human liver microsomes
CYP2C8 genetic polymorphisms may influence outcome of taxane therapy in Roma and Hungarian populations.
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, benzo(a)pyrene, 7-ethyoxycoumarin, and the anti-cancer drug taxol. This gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. Several transcript variants encoding a few different isoforms have been found for this gene.
cytochrome P450 2C8
, cytochrome P450 CYP2C74
, Cytochrome P450 2C8
, cytochrome P450, family 2, subfamily C, polypeptide 8
, P450 form 1
, cytochrome P450 IIC2
, cytochrome P450 MP-12
, cytochrome P450 MP-20
, cytochrome P450 form 1
, cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 8
, flavoprotein-linked monooxygenase
, microsomal monooxygenase
, s-mephenytoin 4-hydroxylase
, xenobiotic monooxygenase