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Fertilization consists of a sequence of specific cell-cell interactions culminating in the fusion of the sperm and egg plasma membranes.
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Human CRISP1 Protein expressed in - ABIN1047968
Wuttke, Müller, Nitsche, Paulsson, Hanisch, Maurer: Structural characterization of human recombinant and bone-derived bone sialoprotein. Functional implications for cell attachment and hydroxyapatite binding. in The Journal of biological chemistry 2001
Show all 2 Pubmed References
Epididymal CRISP1 mediates sperm-zona pellucida binding through its interaction with ZP3 (zeige ZP3 Proteine).
Seminal CRISP1 combined with neutral alpha glucosidase (zeige AGLU Proteine) activity can potentially distinguish between obstructive and nonobstructive azoospermia.
CRISP1 was in the seminal plasma of normal and vasovasostomized men, but not in that of vasectomized men. The soluble concentration of CRISP1 was significantly higher in the seminal plasma of vasovasostomized men as compared with that from normal men.
patch clamping of sperm revealed that CRISP1 has the ability to regulate CatSper (zeige CATSPER1 Proteine), the principal sperm Ca(2 (zeige CA2 Proteine)+) channel involved in hyperactivation and essential for fertility
These results suggest that CRISP1 may be an important structural component of mouse hair and that its strain-specific dysregulation may indicate a predisposition to hair shaft disease such as Alopecia areata
These results indicate that CRISP (zeige CRISP2 Proteine) proteins are players in the mammalian fertilization process.
Fertilization consists of a sequence of specific cell-cell interactions culminating in the fusion of the sperm and egg plasma membranes. Recognition, binding, and fusion occur through the interaction of complementary molecules that are localized to specific domains of the sperm and egg plasma membranes. In the sperm, the postacrosomal region or equatorial segment is involved in sperm-egg plasma membrane fusion. The protein encoded by this gene is a member of the cysteine-rich secretory protein (CRISP) family. It is expressed in the epididymis, is secreted into the epididymal lumen, and binds to the postacrosomal region of the sperm head, where it plays a role in sperm-egg fusion. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
, AEG-related protein
, acidic epididymal glycoprotein homolog
, acidic epididymal glycoprotein-like 1
, cysteine-rich secretory protein-1 delta
, SCP 1
, acidic epididymal glycoprotein 1
, sperm-coating glycoprotein 1
, cysteine-rich secretory protein 1
, androgen-dependent acidic epididymal glycoprotein
, cystein rich secretory protein 1
, cysteine-rich secretory protein-1