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Crystallins are separated into two classes taxon-specific, or enzyme, and ubiquitous. Zusätzlich bieten wir Ihnen CRYAB Kits (54) und CRYAB Proteine (32) und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal CRYAB Primary Antibody für ICC, IF - ABIN250947
Wu, Glickstein, Liu, Fujita, Li, Yang, Duvoisin, Wan: The anaphase-promoting complex coordinates initiation of lens differentiation. in Molecular biology of the cell 2007
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Cow (Bovine) Monoclonal CRYAB Primary Antibody für ELISA, ICC - ABIN361808
Bullard, Ferguson, Minajeva, Leake, Gautel, Labeit, Ding, Labeit, Horwitz, Leonard, Linke: Association of the chaperone alphaB-crystallin with titin in heart muscle. in The Journal of biological chemistry 2004
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Human Monoclonal CRYAB Primary Antibody für WB - ABIN1944889
Kramps, de Man, de Jong: The primary structure of the B2 chain of human alpha-crystallin. in FEBS letters 1977
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Human Polyclonal CRYAB Primary Antibody für ICC, IF - ABIN250945
Liu, Qi, Chen, Shaw, Cai, Smith, Grant, Boulton: Targeting the IRE1α/XBP1 and ATF6 arms of the unfolded protein response enhances VEGF blockade to prevent retinal and choroidal neovascularization. in The American journal of pathology 2013
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Human Monoclonal CRYAB Primary Antibody für IHC, ELISA - ABIN965938
Rajasekaran, Connell, Christians, Yan, Taylor, Orosz, Zhang, Stevenson, Peshock, Leopold, Barry, Loscalzo, Odelberg, Benjamin: Human alpha B-crystallin mutation causes oxido-reductive stress and protein aggregation cardiomyopathy in mice. in Cell 2007
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Human Monoclonal CRYAB Primary Antibody für IHC, ELISA - ABIN1724688
Ghosh, Shenoy, Clark: N- and C-Terminal motifs in human alphaB crystallin play an important role in the recognition, selection, and solubilization of substrates. in Biochemistry 2006
Cow (Bovine) Monoclonal CRYAB Primary Antibody für ELISA, ICC - ABIN361812
Cobb, Petrash: alpha-Crystallin chaperone-like activity and membrane binding in age-related cataracts. in Biochemistry 2002
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Cow (Bovine) Polyclonal CRYAB Primary Antibody für ICC, IF - ABIN4280174
Dong, Dong, Kase, Ando, Fukuhara, Kinoshita, Inafuku, Tagawa, Ishizuka, Saito, Murata, Kanda, Noda, Ishida: Phosphorylation of alphaB-crystallin in epiretinal membrane of human proliferative diabetic retinopathy. in International journal of ophthalmology 2016
Mouse (Murine) Polyclonal CRYAB Primary Antibody für ELISA, WB - ABIN262288
Ousman, Tomooka, van Noort, Wawrousek, OConnor, Hafler, Sobel, Robinson, Steinman: Protective and therapeutic role for alphaB-crystallin in autoimmune demyelination. in Nature 2007
Human Polyclonal CRYAB Primary Antibody für ICC, IF - ABIN407098
Chauhan, Nelson, Marriott, Bost: Alpha beta-crystallin expression and presentation following infection with murine gammaherpesvirus 68. in Autoimmunity 2013
alphaB-crystallin mutants carrying point substitutions in the C-terminal domain
Heparan sulfate mediates cell uptake of alphaB-crystallin fused to the glycoprotein C (zeige MUC15 Antikörper) cell penetration peptide
Our findings suggest that serum level of miR (zeige MLXIP Antikörper)-491 has potential as a biomarker for predicting OS progression and prognosis of OS patients. miR (zeige MLXIP Antikörper)-491 exerts its role by directly targeting alphaB-crystallin (CRYAB) in OS.
A missense mutation (p.D109G) in CRYAB causes restrictive cardiomyopathy (RCM (zeige Unc5c Antikörper)).
Using a combination of co-sedimentation centrifugation, viscometric assays and electron microscopy of negatively stained filaments to analyse the in vitro assembly of desmin (zeige DES Antikörper) filaments, this study shows that the binding of CRYAB to desmin (zeige DES Antikörper) is subject to its assembly status, to the subunit organization within filaments formed and to the integrity of the C-terminal tail domain of desmin (zeige DES Antikörper).
Overexpression of both HSPB5 and Hsp27 significantly reduced the intracellular aggregation of alpha-synuclein.
Glutathione-S-transferase (zeige GSTa2 Antikörper) - HspB1 (zeige HSPB1 Antikörper) fusion protein prevents more aggregation of malate dehydrogenase (zeige ME1 Antikörper) compared to glutathione-S-transferase (zeige GSTa2 Antikörper) -HspB5 fusion protein and wild type HspB1 (zeige HSPB1 Antikörper).
Mechanistic studies revealed KLF4 (zeige KLF4 Antikörper) specifically bound the promoter of CRYAB and upregulated CRYAB expression in human osteosarcoma cells.
mRNA levels of HSP family members (HSP70B', HSP72 (zeige HSPA1A Antikörper), HSP40/DNAJ (zeige DNAJB1 Antikörper), and HSP20 (zeige HSPB6 Antikörper)/CRYAB) are upregulated by the intracellular MMP3 (zeige MMP3 Antikörper) overload.
HspB5 maybe trigger the epithelial-mesenchymal transition in colorectal cancer (CRC (zeige CALR Antikörper)) by activating the ERK (zeige EPHB2 Antikörper) signaling pathway. It is a potential tumor biomarker for CRC (zeige CALR Antikörper) diagnosis and prognosis.
findings offer additional insight into the early transcriptional changes caused by Cryaa (zeige CRYAA Antikörper) and Cryab mutations associated with autosomal dominant cataracts, and indicate that the transcript levels of certain genes are affected by the expression of mutant alpha-crystallin in vivo
desmin and alphaBeta-crystallin are localized at sarcoplasmic reticulum (SR)-mitochondria-associated membranes (MAMs), where they interact with VDAC, Mic60 - the core component of mitochondrial contact site and cristae organizing system (MICOS) complex - and ATP synthase, suggesting that these associations could be crucial in mitoprotection at different levels.
This study demonstrated that HspB5 mRNA localization in myelin-enriched white and gray matter
alphaB-crystallin is an important regulator of epithelial-mesenchymal transition, acting as a molecular chaperone (zeige HSP90AA1 Antikörper) for SMAD4 (zeige SMAD4 Antikörper) and as its potential therapeutic target for preventing subretinal fibrosis development in neovascular age-related macular degeneration
It is a non-Hsp gene, which is essential for HSF1 (zeige HSF1 Antikörper)-mediated maintenance of whole body homeostasis.
A previously unrecognized link between c-Jun (zeige JUN Antikörper) and Nrf2 (zeige NFE2L2 Antikörper) transcription factors and redox-induced CRYAB expression in muscle cells.
CryAB protects decidualization against stress conditions.
TNF-alpha (zeige TNF Antikörper)-induced endothelial adhesion molecule (zeige NCAM1 Antikörper) expression is reduced in inflamed vessels of alphaB-crystallin deficient mice, and leukocyte rolling velocity and IkappaB levels are increased.
Study shows that overexpression of Bcl-2 (zeige BCL2 Antikörper) is sufficient to reduce the levels and overall architecture of protein deposition in the transgenic CryABR120G/Bcl-2 (zeige BCL2 Antikörper) hearts.
alphaB-crystallin is over-expressed in fibrotic lung tissue and favors TGF-beta1 (zeige TGFB1 Antikörper) pathway via its role in modulating the cellular localization of Smad4 (zeige SMAD4 Antikörper).
The alphaB-crystallin content of bovine type I muscle fibers is quantitatively similar to that in the predominantly type I fibers of rat soleus muscle.
In the presence of alpha-crystallin or GroEL (zeige GroEL Antikörper) the kinetic of GAPDH (zeige GAPDH Antikörper) aggregation is changed from the diffusion-limited cluster-cluster aggregation to the reaction-limited cluster-cluster aggregation.
one of the functions of alphaB-crystallin is to bind microtubules via microtubule binding proteins and to give the MTs (zeige NEU2 Antikörper) resistance to disassembly
The study provides evidence for the regulation of the chaperone activity of alphaB-crystallin by phosphorylation and indicates that this may play an important role in alleviating the pathogenic effects associated with protein conformational diseases.
This study clearly demonstrated that both the length and electrostatic charge of the COOH-terminal segment play crucial roles in governing the structural stability and chaperone activity of alphaB-crystallin.
Crystallins are separated into two classes taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families\; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (sHSP also known as the HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone\; instead they hold them in large soluble aggregates. Post-translational modifications decrease the ability to chaperone. These heterogeneous aggregates consist of 30-40 subunits\; the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. Alpha-A and alpha-B gene products are differentially expressed\; alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Elevated expression of alpha-B crystallin occurs in many neurological diseases\; a missense mutation cosegregated in a family with a desmin-related myopathy.
alpha-crystallin B chain
, heat shock protein beta-5
, heat-shock 20 kD like-protein
, renal carcinoma antigen NY-REN-27
, rosenthal fiber component
, alpha B-crystallin
, crystallin, alpha 2
, Crystallin, alpha polypeptide 2
, hypothetical protein
, crystallin, alpha B
, alpha B crystallin
, crystallin, alpha polypeptide 2
, Alpha-crystallin B chain