Telefon:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@antikoerper-online.de

CRYAB Antikörper (AA 1-175)

CRYAB Reaktivität: Human WB, ELISA, IHC Wirt: Maus Monoclonal 1D11C6E6 unconjugated
Produktnummer ABIN1724688
  • Target Alle CRYAB Antikörper anzeigen
    CRYAB (Crystallin, alpha B (CRYAB))
    Bindungsspezifität
    • 35
    • 27
    • 19
    • 15
    • 15
    • 7
    • 6
    • 6
    • 5
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-175
    Reaktivität
    • 130
    • 97
    • 84
    • 15
    • 9
    • 8
    • 6
    • 5
    • 5
    • 5
    • 5
    • 3
    • 2
    • 1
    Human
    Wirt
    • 159
    • 32
    • 2
    • 1
    Maus
    Klonalität
    • 152
    • 42
    Monoklonal
    Konjugat
    • 76
    • 11
    • 11
    • 9
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    Dieser CRYAB Antikörper ist unkonjugiert
    Applikation
    • 139
    • 73
    • 66
    • 66
    • 56
    • 36
    • 33
    • 33
    • 17
    • 15
    • 11
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
    Aufreinigung
    purified
    Immunogen
    Purified recombinant fragment of CRYAB (aa1-175) expressed in E. coli.
    Klon
    1D11C6E6
    Isotyp
    IgG2a
    Top Product
    Discover our top product CRYAB Primärantikörper
  • Applikationshinweise
    ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Ascitic fluid containing 0.03 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    4°C, -20°C for long term storage
  • Ghosh, Shenoy, Clark: "N- and C-Terminal motifs in human alphaB crystallin play an important role in the recognition, selection, and solubilization of substrates." in: Biochemistry, Vol. 45, Issue 46, pp. 13847-54, (2006) (PubMed).

  • Target
    CRYAB (Crystallin, alpha B (CRYAB))
    Andere Bezeichnung
    CRYAB (CRYAB Produkte)
    Synonyme
    CMD1II antikoerper, CRYA2 antikoerper, CTPP2 antikoerper, CTRCT16 antikoerper, HSPB5 antikoerper, MFM2 antikoerper, Crya-2 antikoerper, Crya2 antikoerper, HspB5 antikoerper, AACRYA antikoerper, CRYAB antikoerper, cryab antikoerper, cryab2 antikoerper, wu:fe37f08 antikoerper, zgc:91937 antikoerper, crystallin alpha B antikoerper, crystallin, alpha B antikoerper, hypothetical protein antikoerper, crystallin, alpha B, a antikoerper, crystallin, alpha B, b antikoerper, CRYAB antikoerper, Cryab antikoerper, ZK1128.7 antikoerper, cryaba antikoerper, cryabb antikoerper
    Hintergrund

    Description: Crystallin, alpha B. Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families, beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (sHSP also known as the HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone, instead they hold them in large soluble aggregates. Post-translational modifications decrease the ability to chaperone. These heterogeneous aggregates consist of 30-40 subunits, the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. Alpha-A and alpha-B gene products are differentially expressed, alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Elevated expression of alpha-B crystallin occurs in many neurological diseases, a missense mutation cosegregated in a family with a desmin-related myopathy.

    Aliases: CRYA2, CTPP2, HSPB5, CRYAB

    Gen-ID
    1410
    HGNC
    1410
Sie sind hier:
Kundenservice