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The protein encoded by CKM is a cytoplasmic enzyme involved in energy homeostasis and is an important serum marker for myocardial infarction.
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Human Monoclonal CKM Primary Antibody für - ABIN933705
Wojciechowski, Chase-Baldwin, Wasieloski, Padilla, Vora, Taitt: Enhancement of deoxyribonucleic acid microarray performance using post-hybridization signal amplification. in Analytica chimica acta 2010
Human Polyclonal CKM Primary Antibody für WB - ABIN630557
Mihm, Yu, Reiser, Bauer: Effects of peroxynitrite on isolated cardiac trabeculae: selective impact on myofibrillar energetic controllers. in Biochimie 2003
Human Polyclonal CKM Primary Antibody für IF (p), IHC (p) - ABIN872835
Rueda, Johnson, Giddabasappa, Swaroop, Brooks, Sigel, Chaney, Fox: The cellular and compartmental profile of mouse retinal glycolysis, tricarboxylic acid cycle, oxidative phosphorylation, and ~P transferring kinases. in Molecular vision 2016
On admission, high-sensitivity troponin T/creatine kinase-MB ratio was significantly higher in takotsubo syndrome patients compared to myocardial infarction patients.
These findings support increased CK activity as protection against ischaemia-reperfusion injury, in particular, protection via CKMT2 (zeige CKMT2 Antikörper) in a cardiac-relevant cell line, which merits further investigation in vivo.
Marathoners with a lower CKMM response after the race had a more favorable polygenic profile than runners with high serum CKMM concentrations. This might suggest a significant role of genetic polymorphisms in the levels of exertional muscle damage and rhabdomyolysis.
A positive association was found between PANSS-total and sCK [serum creatine kinase] in SzA [schizoaffective disorder] and BP-I; however, PANSS-positive scores correlated with sCK only in SzA. Serum CK may serve as a biomarker for affective exacerbation rather than psychosis.
These results demonstrate an association between physical performance measures and genetic variation in the muscle-specific (zeige EIF3K Antikörper) creatine kinase gene (rs8111989).
troponin T and creatinine kinase isoenzyme (CK-MB) have roles in combined renal and myocardial injuries in asphyxiated infants
The serum expression levels of myocardial creatine kinase and of galectin-3 (zeige LGALS3 Antikörper) reflect the physiopathology state of children with congenital heart defects after surgical correction.
The variant rs11559024 in the CKM gene (Glu83Gly) was significantly associated with CK levels of statin users.
Based on the obtained results, it may be speculated that the CKM A/G polymorphism is not an important determinant of endurance performance level in Polish and Russian rowers.
We conclude that ILK (zeige ILK Antikörper) negatively and independently of PI3K regulated MEF2C (zeige MEF2C Antikörper) phosphorylation activity and MCK mRNA expression in C2C12 cells
The Fxn (zeige FXN Antikörper) KO/Mck mice tested from one to two months of age showed abnormal gait patterns accompanied by a loss in motor skills.
PI3K and AKT (zeige AKT1 Antikörper) regulated skeletal muscle differentiation by regulating the expression of Myogenin (zeige MYOG Antikörper) and MCK.
strong down-regulation of MCK activity contributes to F-actin instability and induces post-translational modification of alphaB-crystallin (zeige CRYAB Antikörper) and desmin (zeige DES Antikörper)
These studies indicate that the age-associated oxidative and nitrative modification of CKm results in a decrease in its activity and may cause structural changes that promote oligomerization and aggregation.
one of the consequences of M-CK and AK1 (zeige AK1 Antikörper) deficiency is hampered phosphoryl delivery to the actomyosin ATPase (zeige DNAH8 Antikörper), resulting in a loss of contractile performance.
Data show that Six4 (zeige SIX4 Antikörper) is transcriptional regulatory element X (TrexBF (zeige SIX4 Antikörper)) in skeletal myocytes and transactivates the muscle creatine kinase enhancer
the expression of muscle creatine kinase (MCK) gene in the heart and skeletal muscle of mice during aging
Dec proteins repressed a MyoD (zeige MYOD1 Antikörper)-activated promoter activity of muscle creatine kinase gene through class A E-box in an HDAC1 (zeige HDAC1 Antikörper)-independent manner.
Creatine kinase (CK) and adenylate kinase (AK) are especially important in facilitating energy metabolism during very high energy demands.
These data demonstrate that initial phosphocreatine hydrolysis in single skeletal muscle fibers is crucial for maintenance of sarcoplasmic reticulum Ca2 (zeige CA2 Antikörper)+ release and peak tension during a bout of repetitive tetanic contractions.
role of linker on the isolated C-terminal domain of rabbit muscle creatine kinase
when gly(268) in rabbit muscle-specific (zeige EIF3K Antikörper) creatine kinase was substituted with asn(268), the rabbit muscle-specific (zeige EIF3K Antikörper) CK G286N mutant specific activity at pH 8.0 and 10 degrees C was more than 2-fold higher than that in the wild-type rabbit enzyme
In addition to its role in the in vivo functions, the linker also played a crucial role in the stability and folding of CKM.
The protein encoded by this gene is a cytoplasmic enzyme involved in energy homeostasis and is an important serum marker for myocardial infarction. The encoded protein reversibly catalyzes the transfer of phosphate between ATP and various phosphogens such as creatine phosphate. It acts as a homodimer in striated muscle as well as in other tissues, and as a heterodimer with a similar brain isozyme in heart. The encoded protein is a member of the ATP:guanido phosphotransferase protein family.
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