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The protein encoded by CPOX is the sixth enzyme of the heme biosynthetic pathway. Zusätzlich bieten wir Ihnen Coproporphyrinogen Oxidase Antikörper (28) und und viele weitere Produktgruppen zu diesem Protein an.
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The monomer form of mutated CPOX did not show any activity and homodimeric enzymes derived from Hereditary coproporphyria (HCP (zeige AMBP Proteine)) mutant showed low activity (<20% of the control).
Polymorphism of coproporphyrinogen oxidase is associated with genetic susceptibility to the adverse neurobehavioral effects of Hg exposure in children.
Deletion of the fifth exon in the CPOX gene is associated with hereditary coproporphyria.
CPOX polymorphisms are associated with biological media contamination and apoptosis disorders.
competitive action of both uroporphyrinogen decarboxylase (zeige UROD Proteine) and CPO on the same diacetate porphyrinogen substrate provides additional perspectives on the potential existence of abnormal pathways for heme biosynthesis
disease-producing mutations in the CPO gene in nine Swedish families with hereditary coproporphyria
coproporphyrinogen III oxidase sequence matches many structural features from urate oxidase (zeige UOX Proteine)
Modulation of penetrance by the wild-type allele in dominantly inherited erythrohepatic and acute hepatic porphyrias was studied using CPO.
All other type of mutations or missense mutations mapped elsewhere throughout the CPO gene, lead to coproporphyrin accumulation and subsequently typical HCP (zeige AMBP Proteine).
CPO mutations form the structural basis of hereditary coproporphyria.
The mechanisms by which impairment of CPOX leads to lens opacity in the NCT (zeige NCSTN Proteine) are elusive. However, our data illuminate a hitherto unanticipated involvement of the heme biosynthesis pathway in lens physiology.
The protein encoded by this gene is the sixth enzyme of the heme biosynthetic pathway. The encoded enzyme is soluble and found in the intermembrane space of mitochondria. This enzyme catalyzes the stepwise oxidative decarboxylation of coproporphyrinogen III to protoporphyrinogen IX, a precursor of heme. Defects in this gene are a cause of hereditary coproporphyria (HCP).
, coprogen oxidase
, coproporphyrinogen-III oxidase, mitochondrial
, Coproporphyrinogen III oxidase, mitochondrial precursor (Coproporphyrinogenase) (Coprogen oxidase) (COX)
, clone 560
, coproporphyrinogen oxidase
, coproporphyrinogen-III oxidase, mitochondrial-like
, Coproporphyrinogen oxidase