anti-Collagen, Type XVII, alpha 1 (COL17A1) Antikörper

COL17A1 encodes the alpha chain of type XVII collagen. Zusätzlich bieten wir Ihnen COL17A1 Kits (13) und COL17A1 Proteine (8) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
COL17A1 294027  
COL17A1 1308 Q9UMD9
COL17A1 12821 Q07563
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Top anti-COL17A1 Antikörper auf

Showing 10 out of 46 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Kaninchen Unkonjugiert IHC, WB Immunohistochemical analysis of Collagen 17 alpha 1 staining in human colon cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then Western blot analysis of Collagen 17 alpha 1 expression in HepG2 (A), NIH3T3 (B) whole cell lysates. 200 μL Anmelden zum Anzeigen 13 bis 14 Tage
Human Kaninchen Unkonjugiert FACS, IHC (p), WB Western blot analysis of COL17A1 Antibody (Center) (ABIN653043) in A375, A2058, HL-60, MCF-7 cell line lysates (35 µg/lane). COL17A1 (arrow) was detected using the purified polyclonal antibody. COL17A1 Antibody (Center) (ABIN653043) IHC analysis in formalin fixed and paraffin embedded skin tissue followed by peroxidase conjugation of the secondary antibody and DAB staining 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
Human Kaninchen Unkonjugiert IHC (p), WB <span>COL17A1 Antibody (Center) flow cytometric analysis of A2058 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.</span> <span>COL17A1 Antibody (Center) IHC analysis in formalin fixed and paraffin embedded skin tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the COL17A1 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.</span> 0.4 mL Anmelden zum Anzeigen 6 bis 8 Tage
Human Kaninchen Unkonjugiert ELISA, IHC 100 μL Anmelden zum Anzeigen 16 Days
Human Kaninchen Unkonjugiert EIA, IHC (fro), IF, WB 0.1 mg Anmelden zum Anzeigen 6 bis 8 Tage
Human Kaninchen Unkonjugiert ELISA, WB   100 μL Anmelden zum Anzeigen 16 Days
Human Kaninchen Unkonjugiert FACS, WB Overlay histogram showing A431 cells stained with Antibody (green line). The cells were fixed with 2% paraformaldehyde (10 min) and then permeabilized with 90% methanol for 10 min. The cells were then icubated in 2% bovine serum albumin to block non-specific protein-protein interactions followed by the antibody (1:25 dilution) for 60 min at 37ºC. The secondary antibody used was Goat-Anti-Rabbit IgG, DyLight 488 Conjugated Highly Cross-Adsorbed(OH191631) at 1/200 dilution for 40 min at 37ºC. Isotype control antibody (blue line) was rabbit IgG (1ug/1x10^6 cells) used under the same conditions. Acquisition of >10, 000 events was performed. Western Blot at 1:2000 dilution Lane 1: A2058 whole cell lysate Lane 2: A375 whole cell lysate Lane 3: HL-60 whole cell lysate Lane 4: MCF-7 whole cell lysate Lysates/proteins at 20 ug per lane. 400 μL Anmelden zum Anzeigen 2 bis 3 Tage
Human Maus Unkonjugiert EIA, IHC (fro), WB   0.1 mg Anmelden zum Anzeigen 6 bis 8 Tage
Maus Kaninchen Unkonjugiert IHC (fro) Immunofluorescence staining of Collagen type XVII alpha 1 chain with Cat.No. AP23435PU-N (1:100) followed by an anti-rabbit FITC conjugated secondary antibody in cryosections of mouse skin. 0.1 mg Anmelden zum Anzeigen 6 bis 8 Tage
Human Kaninchen Unkonjugiert IHC (p), WB Western blot analysis of Lane 1: RT-4, Lane 2: U-251 MG, Lane 3: Human Plasma, Lane 4: Liver, Lane 5: Tonsil with COL17A1 polyclonal antibody . Immunohistochemical staining of human skin with COL17A1 polyclonal antibody  shows strong cytoplasmic positivity in epidermal cells. 100 μL Anmelden zum Anzeigen 11 bis 12 Tage

Weitere Antikörper gegen COL17A1 Interaktionspartner

Human Collagen, Type XVII, alpha 1 (COL17A1) Interaktionspartner

  1. Suspension survival mediated by PP2A (zeige PPP2R4 Antikörper)-STAT3 (zeige STAT3 Antikörper)-Col (zeige HDAC1 Antikörper) XVII determines tumor initiation and metastasis in cancer stem cells.

  2. Bullous pemphigoid (zeige DST Antikörper) patients with the HLA-DQB1 (zeige HLA-DQB1 Antikörper)*03:01 allele show an increased T-cell avidity to several epitopes of BP180, particularly the BP180-NC16a domain. (Review)

  3. C-terminal processing induces dynamic structural changes and neoepitopes for linear IgA (zeige IgA Antikörper) dermatosis autoantibodies on COL17

  4. The corneal dystrophy mapped to chromosome 10q23-q24 is associated with the c.3156C>T variant in COL17A1.

  5. Data suggest that type XVII collagen (COL17) internalization/macropinocytosis by keratinocytes induced by IgG autoantibodies from patients with bullous pemphigoid (zeige DST Antikörper) (BP) is mediated by PKC (protein kinase C (zeige PKC Antikörper)) calcium signaling pathway; BP IgG induced overabundant phosphorylation of COL17.

  6. we have produced five new versatile monoclonal antibodies against the Col 17 (zeige COL Antikörper) endodomain that are superior to ectodomain antibodies in diagnosing and differentiating between JEB-gen (zeige GEN1 Antikörper) intermed and JEB-loc (zeige ILK Antikörper)/carriers

  7. Results show that aberrant epigenetic control is a key driver of COL17A1 gene misexpression and tumor cell invasion in a variety of epithelial neoplasm. These findings have significant clinical implications, suggesting that the COL17A1 promoter methylation status can be used to predict patient outcome.

  8. Case Report: IgA (zeige IgA Antikörper) autoantibodies targeting the NC16A domain rather than the shed ectodomains of COL17 resulted in linear IgA bullous dermatosis (zeige LAD1 Antikörper) in a pregnant woman.

  9. ELISA for IgE anti-NC16a is a helpful parameter in the modification of current treatment and the assessment of risk of relapse in bullous pemphigoid (zeige DST Antikörper).

  10. R1303Q in COL17 hampers C-terminal cleavage of COL17. Increase in remnants of non-cleaved COL17 ectodomain in extracellular matrix (ECM (zeige MMRN1 Antikörper)) induces aberrant laminin 332 deposition in ECM (zeige MMRN1 Antikörper), which may be associated with disorganized basement membrane formation.

Mouse (Murine) Collagen, Type XVII, alpha 1 (COL17A1) Interaktionspartner

  1. Here, the authors show that COL17 plays a central role in regulating interfollicular epidermis (IFE) proliferation. Loss of COL17 leads to transient IFE hypertrophy in neonatal mice owing to aberrant Wnt (zeige WNT2 Antikörper) signaling.

  2. The aging process can be recapitulated by Col17a1 deficiency and prevented by the forced maintenance of COL17A1 in hair follicle stem cell (HFSCs), demonstrating that COL17A1 in HFSCs orchestrates the stem cell-centric aging program of the epithelial mini-organ.

  3. The deletion of the bullous pemphigoid (zeige DST Antikörper) epitope region of collagen XVII induces blistering, autoimmunization, and itching in a mouse disease model.

  4. Through an unbiased genetic approach involving a combination of QTL mapping and positional cloning, we demonstrate that Col17a1 is a strong genetic modifier of the non-Herlitz JEB that develops in Lamc2 (zeige LAMC2 Antikörper)(jeb) mice

  5. These results provide mechanistic evidence that ColXVII coordinates keratinocyte adhesion and directed motility by interfering integrin dependent PI3K activation and by stabilizing lamellipodia

  6. Neutrophil elastase (zeige ELANE Antikörper) cleaves the murine hemidesmosomal protein BP180/type XVII collagen and generates degradation products that modulate experimental bullous pemphigoid (zeige DST Antikörper)

  7. Analysis of Col17a1-null mice revealed that COL17A1 is critical for the self-renewal of hair follicle stem cells through maintaining their quiescence and immaturity.

  8. bullous pemphigoid antigen 2 has a role in eliciting specific IgG and the immune responses arising in epidermolysis bullosa

  9. ADAM9 (zeige ADAM9 Antikörper) and ADAM10 (zeige ADAM10 Antikörper) can both contribute to collagen XVII shedding in skin.

Cow (Bovine) Collagen, Type XVII, alpha 1 (COL17A1) Interaktionspartner

  1. results show that the cleavage of BP180 occurring within the NC16A domain is mediated by a membrane-associated metalloprotease and suggest involvement of the cleavage in hemidesmosomal disassembly(bullous pemphigoid antigen 180/type XVII collagen)

COL17A1 Antigen-Profil

Protein Überblick

This gene encodes the alpha chain of type XVII collagen. Unlike most collagens, collagen XVII is a transmembrane protein. Collagen XVII is a structural component of hemidesmosomes, multiprotein complexes at the dermal-epidermal basement membrane zone that mediate adhesion of keratinocytes to the underlying membrane. Mutations in this gene are associated with both generalized atrophic benign and junctional epidermolysis bullosa. Two homotrimeric forms of type XVII collagen exist. The full length form is the transmembrane protein. A soluble form, referred to as either ectodomain or LAD-1, is generated by proteolytic processing of the full length form.

Genbezeichner und Symbole assoziert mit COL17A1

  • collagen type XVII alpha 1 chain (Col17a1) Antikörper
  • collagen, type XVII, alpha 1b (col17a1b) Antikörper
  • collagen type XVII alpha 1 chain (COL17A1) Antikörper
  • collagen, type XVII, alpha 1 (Col17a1) Antikörper
  • BA16H23.2 Antikörper
  • BP180 Antikörper
  • BPA-2 Antikörper
  • Bpag Antikörper
  • Bpag2 Antikörper
  • COL17A1 Antikörper
  • fk89a06 Antikörper
  • LAD-1 Antikörper
  • si:ch211-223p8.6 Antikörper
  • wu:fk89a06 Antikörper

Bezeichner auf Proteinebene für COL17A1

collagen alpha-1(XVII) chain , procollagen, type XVII, alpha 1 , col17a1a , collagen, type XVII, alpha 1 , collagen alpha-1(XVII) chain-like , 180 kDa bullous pemphigoid antigen 2 , alpha 1 type XVII collagen , bA16H23.2 (collagen, type XVII, alpha 1 (BP180)) , bullous pemphigoid antigen 2 (180kD) , collagen XVII, alpha-1 polypeptide , bullous pemphigoid antigen 2 , bullous pemphigoid antigen 180 , novel collagen protein , Collagen alpha-1(XVII) chain , bullous pemphigoid autoantigen 2 , Bullous pemphigoid antigen 2 , collagen type XVII

294027 Rattus norvegicus
568794 Danio rerio
100452122 Pongo abelii
100069671 Equus caballus
100604365 Nomascus leucogenys
1308 Homo sapiens
12821 Mus musculus
513804 Bos taurus
396503 Gallus gallus
403739 Canis lupus familiaris
101843802 Mesocricetus auratus
Ausgewählte Anbieter für anti-COL17A1 (COL17A1) Antikörper
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