Coagulation Factor X Proteine (F10)

F10 encodes the vitamin K-dependent coagulation factor X of the blood coagulation cascade. Zusätzlich bieten wir Ihnen Coagulation Factor X Antikörper (245) und Coagulation Factor X Kits (70) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
F10 2159 P00742
F10 14058 O88947
F10 29243 Q63207
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Showing 10 out of 33 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$6,869.04
Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$6,869.04
Details
Baculovirus infected Insect Cells Human His tag 10 μg Anmelden zum Anzeigen 20 bis 21 Tage
$250.80
Details
Escherichia coli (E. coli) Human His tag,T7 tag 50 μg Anmelden zum Anzeigen 13 bis 16 Tage
$438.00
Details
Human Cells Maus His tag   50 μg Anmelden zum Anzeigen 4 Days
$600.88
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen Verfügbar
$814.00
Details
Human Cells Human Fc Tag   10 μg Anmelden zum Anzeigen 4 Days
$234.03
Details
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
Details
Human Cells Human Fc Tag   10 μg Anmelden zum Anzeigen 15 bis 16 Tage
$325.00
Details
Human Human Unkonjugiert   400 μg Anmelden zum Anzeigen 2 bis 3 Tage
$295.00
Details

F10 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , , , , ,
, , , ,
Mouse (Murine) , , , ,
,
Rat (Rattus) , ,

Weitere Proteine zu Coagulation Factor X (F10) Interaktionspartnern

Human Coagulation Factor X (F10) Interaktionspartner

  1. miR-24 was overexpressed in major trauma-induced coagulopathy (TIC) patients. The negative correlation of miR-24 with FX suggested the possibility that miR-24 might inhibit the synthesis of FX during TIC.

  2. this study demonstrated that thrombin and factor Xa cleavage sites on HEV pORF1 are obligatory for HEV replication.

  3. zymogen-like factor Xa variants are conformationally dynamic and ligands such as its cofactor, factor Va, stabilize the molecule rescuing procoagulant activity. At the site of vascular injury, the variants in the presence of factor Va serve as effective prohemostatic agents.

  4. Data suggest that, for all coagulation proteins tested (prothrombin, factor X, activated factor VII, activated protein C), tighter binding to lipid bilayers (lower Kd) is observed as the proportion of anionic phospholipid increases. These studies were conducted in high-throughput screening using phospholipid bilayers in nanodiscs with multiplexed silicon photonic sensor (micro-ring resonator) array technology.

  5. A coagulation initiating pathway is revealed in which the TF-FVIIa-nascent FXa complex activates FVIII (zeige F8 Proteine) apart from thrombin (zeige F2 Proteine) feedback.

  6. Data suggest oxidized lipid vesicles with phosphatidylserine/polyunsaturated fatty acids promote inactivation of ZPI (zeige SERPINA10 Proteine)-PZ complex or free ZPI (zeige SERPINA10 Proteine); binding of PZ-complexed or free ZPI (zeige SERPINA10 Proteine) to oxidized vesicles mediates inactivation of ZPI (zeige SERPINA10 Proteine) (an inhibitor of FXa); blocking heparin- (anticoagulant-)binding site on ZPI (zeige SERPINA10 Proteine) interferes with binding to lipid or PZ. (ZPI (zeige SERPINA10 Proteine) = protein Z-dependent protease inhibitor (zeige SERPINA10 Proteine); PZ = protein Z (zeige PROZ Proteine); FXa = factor Xa)

  7. Factor Va reduced by 100-fold the apparent Kd of myosin for factor Xa (Kd approximately 0.48 nM), primarily by reducing koff, indicating formation of a stable ternary complex of myosin:Xa:Va.

  8. PTX2 (zeige APCS Proteine) was identified PTX2 (zeige APCS Proteine) as a novel partner for FX, and both proteins cooperated to prevent their SR-AI (zeige MSR1 Proteine)-mediated uptake by macrophages.

  9. annexin A2 (zeige ANXA2 Proteine) contributes to lung injury and fibrotic disease by mediating the fibrogenic actions of FXa.

  10. Individuals suffering from relapsing-remitting and secondary progressive multiple sclerosis had significantly higher prothrombin (zeige F2 Proteine) and factor X levels than healthy donors, whereas levels were unchanged in primary progressive MS and neuromyelitis optica patients.

Mouse (Murine) Coagulation Factor X (F10) Interaktionspartner

  1. PTX2 (zeige PITX2 Proteine) was identified PTX2 (zeige PITX2 Proteine) as a novel partner for FX, and both proteins cooperated to prevent their SR-AI (zeige MSR1 Proteine)-mediated uptake by macrophages.

  2. annexin A2 (zeige ANXA2 Proteine) contributes to lung injury and fibrotic disease by mediating the fibrogenic actions of FXa.

  3. Enhanced FXa and PAR2 (zeige F2RL1 Proteine) exacerbate DN and that both are promising targets for preventing diabetic nephropathy.

  4. Macrophages regulate FX plasma levels in an SR-AI (zeige MSR1 Proteine)-dependent manner.

  5. Factor Xa has a role in inhibiting HMGB1 (zeige HMGB1 Proteine)-induced septic responses in human umbilical vein endothelial cells and in mice

  6. Selective inhibition of FXa improves the left ventricular function during CVB3-induced myocarditis and seems to be associated with an improved myocardial remodeling.

  7. Activated factor X signaling via protease-activated receptor 2 (zeige F2RL1 Proteine) suppresses pro-inflammatory cytokine production from lipopolysaccharide-stimulated myeloid cells.

  8. There was no detectable increase in plasma levels of mouse FX after active-site inhibited human APC (zeige APC Proteine) administration to mice overexpressing human EPCR (zeige PROCR Proteine). FX does not effectively interact with EPCR (zeige PROCR Proteine) in vivo, at least in regards to the mouse system.

  9. investigation of role of F10a in progression of diabetic nephropathy: data from studies using inhibitor of F10a suggest that F10a does play a role in development of proteinemia, glomerular hypertrophy, and protein deposition in kidney of db/db (zeige LEPR Proteine) mice

  10. Data suggest that tissue factor (zeige F3 Proteine) and factor V induction by LPS (zeige TLR4 Proteine) may in part accelerate mesangioproliferative glomerulonephritis through activation of factor X and downstream proinflammatory and procoagulant mechanisms.

Cow (Bovine) Coagulation Factor X (F10) Interaktionspartner

  1. Identify potential phosphatidylserine-specific binding sites in the membrane binding domain of coagulation factor X.

  2. Data suggest factor Xa (FXa) and factor Va (FVa) compete to bind FXa on both PS model membranes and microparticles from activated platelets; this competition between dimerization/prothrombinase (zeige FGL2 Proteine) complex formation appears to regulate blood coagulation.

  3. thrombin (zeige F2 Proteine) and factor Xa diffusion along the heparin molecule explains the effects of extended heparin chain lengths

  4. Factor Xa (fXa), a key serine protease (zeige F2 Proteine) of the coagulation system, was used as a model enzyme to test the canonical conformation hypothesis.

Zebrafish Coagulation Factor X (F10) Interaktionspartner

  1. These findings as well as the prolonged survival of f10(-/-) mutants will enable us to expand our understanding of the molecular mechanisms of hemostasis, including a platform for screening variants of uncertain significance in patients with F10 deficiency and other coagulation disorders

Coagulation Factor X (F10) Protein Überblick

Protein Überblick

This gene encodes the vitamin K-dependent coagulation factor X of the blood coagulation cascade. This factor undergoes multiple processing steps before its preproprotein is converted to a mature two-chain form by the excision of the tripeptide RKR. Two chains of the factor are held together by 1 or more disulfide bonds\; the light chain contains 2 EGF-like domains, while the heavy chain contains the catalytic domain which is structurally homologous to those of the other hemostatic serine proteases. The mature factor is activated by the cleavage of the activation peptide by factor IXa (in the intrisic pathway), or by factor VIIa (in the extrinsic pathway). The activated factor then converts prothrombin to thrombin in the presence of factor Va, Ca+2, and phospholipid during blood clotting. Mutations of this gene result in factor X deficiency, a hemorrhagic condition of variable severity.

Genbezeichner und Symbole assoziert mit Coagulation Factor X Proteine (F10)

  • coagulation factor X (F10)
  • coagulation factor X (f10)
  • coagulation factor X (CpipJ_CPIJ012712)
  • coagulation factor X (CpipJ_CPIJ014863)
  • coagulation factor X (CpipJ_CPIJ016937)
  • coagulation factor X (CpipJ_CPIJ017791)
  • Coagulation factor X (fa10)
  • coagulation factor 10 L homeolog (f10.L)
  • Cf10 Protein
  • f10 Protein
  • fi12c10 Protein
  • fX Protein
  • FXA Protein
  • wu:fi12c10 Protein

Bezeichner auf Proteinebene für Coagulation Factor X Proteine (F10)

Stuart-Prower factor , factor Xa , prothrombinase , stuart factor , coagulation factor 10 , VAP , factor XA light chain , virus activating protease , virus-activating protease , coagulation factor X , vitamin K dependent serine protease , coagulation factor X preproprotein , blood coagulation factor X , Coagulation factor X , coagulation factor 10 L homeolog

GENE ID SPEZIES
2159 Homo sapiens
14058 Mus musculus
29243 Rattus norvegicus
280787 Bos taurus
282670 Danio rerio
395876 Gallus gallus
445942 Takifugu rubripes
452679 Pan troglodytes
476993 Canis lupus familiaris
714132 Macaca mulatta
790961 Ornithorhynchus anatinus
6045845 Culex quinquefasciatus
6048453 Culex quinquefasciatus
6050511 Culex quinquefasciatus
6052088 Culex quinquefasciatus
100008647 Oryctolagus cuniculus
100022394 Monodelphis domestica
100137443 Papio anubis
100380501 Salmo salar
100408094 Callithrix jacchus
100453258 Pongo abelii
100471482 Ailuropoda melanoleuca
100607918 Nomascus leucogenys
100726878 Cavia porcellus
101118624 Ovis aries
398778 Xenopus laevis
Ausgewählte Anbieter für Coagulation Factor X Proteine (F10)
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