anti-Chromosome 9 Open Reading Frame 72 (C9ORF72) Antikörper

Expansion of a hexanucleotide repeat in non-coding sequence between alternate 5' exons in transcripts from C9ORF72 is associated with 9p-linked ALS (amyotrophic lateral sclerosis) and FTD (frontotemporal dementia) (PMID: 21944778, 21944779). Zusätzlich bieten wir Ihnen C9ORF72 Proteine (4) und und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
C9ORF72 203228 Q96LT7
C9ORF72    
C9ORF72    
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Top anti-C9ORF72 Antikörper auf antikoerper-online.de

Showing 10 out of 68 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Kaninchen Unkonjugiert EIA, WB <span>C9orf46 Antibody (C-term) western blot analysis in 293 cell line lysates (35µg/lane).This demonstrates the C9orf46 antibody detected the C9orf46 protein (arrow).</span> 0.4 mL Anmelden zum Anzeigen 6 bis 8 Tage
$390.50
Details
Human Kaninchen Unkonjugiert WB C9orf72 Antibody (C-term) (ABIN656852) western blot analysis in MDA-MB231 cell line lysates (35 µg/lane). This demonstrates the C9orf72 antibody detected the C9orf72 protein (arrow). 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$324.50
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Human Kaninchen Unkonjugiert ICC, IF, IHC, IHC (p) Immunohistochemistry-Paraffin: C9orf72 Antibody [NBP1-93504] - Staining of human colon shows strong cytoplasmic positivity in glandular cells. Immunocytochemistry/Immunofluorescence: C9orf72 Antibody [NBP1-93504] - Staining of human cell line U-2 OS shows positivity in cytoplasm & actin filaments. Antibody staining is shown in green. 0.1 mL Anmelden zum Anzeigen 10 bis 13 Tage
$491.63
Details
Human Kaninchen Unkonjugiert ICC, IF, IHC, IHC (p), WB Immunohistochemistry-Paraffin: C9orf72 Antibody [NBP2-15656] - Analysis of paraffin-embedded U87 xenograft, using antibody at 1:500 dilution. Western Blot: C9orf72 Antibody [NBP2-15656] - Sample (30 ug of whole cell lysate) A: Non-transfected 293T lysates B: C9orf72 transfected 293T lysate 10% SDS PAGE gel, diluted at 1:5000. 0.1 mL Anmelden zum Anzeigen 8 bis 11 Tage
$514.63
Details
Human Kaninchen Unkonjugiert IF (p), IHC (p) Antigen: 2 µg/100 µL  Primary: Antiserum, 1:500, 1:1000, 1:2000, 1:4000, 1:8000, 1:16000, 1:32000;  Secondary: HRP conjugated Rabbit Anti-Goat IgG at 1: 5000;  TMB staining Read the data in Microplate Reader by 450nm. Formalin-fixed and paraffin embedded rat brain with labeled Anti-C9orf72 Polyclonal Antibody, Unconjugated (ABIN1386141) at 1:200, followed by conjugation to the secondary antibody and DAB staining 100 μL Anmelden zum Anzeigen 3 bis 7 Tage
$306.90
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Human Kaninchen FITC IF (p)   100 μL Anmelden zum Anzeigen 14 bis 21 Tage
$405.90
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Human Kaninchen Alexa Fluor 488 IF (p)   100 μL Anmelden zum Anzeigen 14 bis 21 Tage
$405.90
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Human Kaninchen Alexa Fluor 350 IF (p)   100 μL Anmelden zum Anzeigen 14 bis 21 Tage
$405.90
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Human Kaninchen Alexa Fluor 555 IF (p)   100 μL Anmelden zum Anzeigen 14 bis 21 Tage
$405.90
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Human Kaninchen Alexa Fluor 647 IF (p)   100 μL Anmelden zum Anzeigen 14 bis 21 Tage
$405.90
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C9ORF72 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
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Am meisten referenzierte anti-C9ORF72 Antikörper

  1. Human Polyclonal C9ORF72 Primary Antibody für ICC, IF - ABIN4286688 : Snowden, Rollinson, Thompson, Harris, Stopford, Richardson, Jones, Gerhard, Davidson, Robinson, Gibbons, Hu, DuPlessis, Neary, Mann, Pickering-Brown: Distinct clinical and pathological characteristics of frontotemporal dementia associated with C9ORF72 mutations. in Brain : a journal of neurology 2012 (PubMed)
    Show all 4 Pubmed References

Weitere Antikörper gegen C9ORF72 Interaktionspartner

Human Chromosome 9 Open Reading Frame 72 (C9ORF72) Interaktionspartner

  1. Demyelinating lesions might facilitate expressivity of C9orf72 expansion, through NF-kappaB (zeige NFKB1 Antikörper) activation. This plausible association may lead to the identification of a therapeutic target in this subgroup of C9orf72-amyotrophic lateral sclerosis patients.

  2. These findings suggest that the presence of a C9orf72 mutation does not influence the tau signature of ALS or ALSci.

  3. We created Smcr8 knockout mice and found that Smcr8 mutant cells exhibit impaired autophagy induction, which is similarly observed in C9orf72 knockdown cells. Mechanistically, SMCR8/C9ORF72 interacts with the key autophagy initiation ULK1 (zeige ULK1 Antikörper) complex and regulates expression and activity of ULK1 (zeige ULK1 Antikörper)

  4. Our study did not find any pathological C9ORF72 repeat expansions in two large groups of patients with disease and multiple system atrophy, suggesting that C9ORF72 expansions do not play a major role in the susceptibility to the wider spectrum of Parkinsonism. However, study identified a statistically significant association between number of repeats and age at onset in Parkinson's disease patients.

  5. Pathogenesis may occur either due to loss of function of the C9orf72 gene, or a toxic gain of function, via the production of repetitive sense and antisense RNA and/or repetitive dipeptide repeat proteins. Recently, mouse knockouts have suggested that a loss of function of C9orf72 alone is insufficient to lead to neurodegeneration, whilst overexpression of hexanucleotide DNA is sufficient in a wide range of model systems

  6. We review what has been published regarding C9orf72 repeat size as modifier for phenotypic characteristics. Conclusive evidence is lacking, partly due to the difficulties in accurately defining the exact repeat size and the presence of repeat variability due to somatic mosaicism

  7. C9orf72 patients had enhanced visual network functional connectivity versus sporadic-motor and sporadic-early cases

  8. C9orf72 and ATXN2 repeat expansions cause ataxia, dementia, and parkinsonism in a Guyana family.

  9. These findings indicate that tracking poly(GP) proteins in Cerebrospinal fluid could provide a means to assess target engagement of G4C2 repeat expansion RNA-based therapies in symptomatic C9ORF72 repeat expansion carriers.

  10. Several family members of the patient suffered of atypical Parkinsonism, lateral amyotrophic sclerosis and dementia. We identified an abnormal hexanucleotide expansion in the C9orf72 gene in the proband.

C9ORF72 Antigen-Profil

Protein Überblick

Expansion of a hexanucleotide repeat in non-coding sequence between alternate 5' exons in transcripts from this gene is associated with 9p-linked ALS (amyotrophic lateral sclerosis) and FTD (frontotemporal dementia) (PMID: 21944778, 21944779). Multiple transcript variants encoding different isoforms have been found for this gene.

Genbezeichner und Symbole assoziert mit C9ORF72

  • chromosome Z C9orf72 homolog (CZH9orf72) Antikörper
  • chromosome 9 open reading frame 72 (C9orf72) Antikörper
  • ALSFTD Antikörper
  • CZH9orf72 Antikörper
  • FTDALS Antikörper

Bezeichner auf Proteinebene für C9ORF72

protein C9orf72

GENE ID SPEZIES
427370 Gallus gallus
203228 Homo sapiens
Ausgewählte Anbieter für anti-C9ORF72 (C9ORF72) Antikörper
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